{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:14:42Z","timestamp":1771478082847,"version":"3.50.1"},"reference-count":25,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPQ (National Council for Scientific and Technological Development) through the Universal Faixa A grant","award":["404350\/2023-2"],"award-info":[{"award-number":["404350\/2023-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Contrast-induced acute kidney injury (CI-AKI) is a significant concern during percutaneous coronary intervention (PCI) procedures. The novel Mehran 2 pre-procedural risk score, an updated version of the original Mehran score, shows promise as a predictive tool. However, its effectiveness specifically in acute coronary syndrome (ACS) patients requires further investigation. This study aims to evaluate the performance of Mehran 2 pre-procedure risk score compared to original score in predicting CI-AKI risk in acute coronary syndrome patients undergoing PCI.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Material and Methods<\/jats:title>\n               <jats:p>A prospective cohort study was conducted with patients with ACS undergoing PCI, who were followed up for 90 days (December 2019\u2013February 2021). The Mehran 2 CI-AKI risk score with pre-procedure data was compared with the original Mehran score. Receiver operating characteristic (ROC) curve and area under the ROC curve (AUC-ROC) were used to evaluate the discriminative capacity.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>192 patients were analyzed and 33% (<jats:italic>n<\/jats:italic>\u00a0=\u00a064) developed CI-AKI. CI-AKI outcome was associated with advanced age, arterial hypertension, chronic kidney disease, troponin T, hemodynamic instability, serum hemoglobin, serum creatinine, and higher both Mehran scores. Both scores demonstrated good agreement. The original Mehran score demonstrated superior CI-AKI stratification with higher sensitivity (85.94%) and specificity (60.16%) compared to the Mehran 2 pre-procedural score (sensitivity 50%, specificity 75%). Significant differences were observed in the discriminative performance between both scores.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>Sociodemographic, clinical, and laboratory variables were associated with CI-AKI. The original Mehran score demonstrated more consistent discriminative capacity for predicting CI-AKI risk in ACS patients undergoing PCI compared to the Mehran 2 pre-procedural score.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.19166","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:05:16Z","timestamp":1744704316000},"page":"e19166","source":"Crossref","is-referenced-by-count":2,"title":["Mehran <i>vs.<\/i> Mehran2 pre-procedure: which score better predicts risk of contrast-induced acute kidney injury in patients with acute coronary syndrome?"],"prefix":"10.7717","volume":"13","author":[{"given":"Matheus Santos","family":"Moitinho","sequence":"first","affiliation":[{"name":"Paulista Nursing School, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Paulista Nursing School, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Galhardo","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Caixeta","sequence":"additional","affiliation":[{"name":"Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduesley","family":"Santana-Santos","sequence":"additional","affiliation":[{"name":"Nursing Post Graduate Program, Federal University of Sergipe, Sao Cristovao, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximina","family":"Cunha","sequence":"additional","affiliation":[{"name":"Paulista Nursing School, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Santana","family":"Prado","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassiane","family":"Dezoti da Fonseca","sequence":"additional","affiliation":[{"name":"Paulista Nursing School, Federal University of Sao Paulo, Sao Paulo, Brazil"},{"name":"Nursing Post Graduate Program, Federal University of Sergipe, Sao Cristovao, Brazil"},{"name":"Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"10.7717\/peerj.19166\/ref-1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/cphy.c110041","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Comprehensive Physiology"},{"key":"10.7717\/peerj.19166\/ref-2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/nep.13769","article-title":"Performance of a pre-procedural Mehran score to predict acute kidney injury after percutaneous coronary intervention","volume":"26","author":"Blanco","year":"2021","journal-title":"Nephrology"},{"key":"10.7717\/peerj.19166\/ref-3","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1161\/CIRCOUTCOMES.114.000903","article-title":"Reducing contrast-induced acute kidney injury using a regional multicenter quality improvement intervention","volume":"7","author":"Brown","year":"2014","journal-title":"Circulation. 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