{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T09:10:10Z","timestamp":1743412210562,"version":"3.40.3"},"reference-count":65,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PIBIC-CNPq"},{"name":"Sao Paulo State Research Foundation","award":["FAPESP, grant#2018\/00191-4"],"award-info":[{"award-number":["FAPESP, grant#2018\/00191-4"]}]},{"name":"NEPAS-FMABC"},{"name":"Centro Universitario FMABC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Urinary stress incontinence has a high prevalence in women, with many associated risk factors, such as high impact and intensity sports due to increased intra-abdominal pressure causing stretching and weakening of the pelvic floor muscles. No previous study has investigated the effects of undulatory resistance training (URT), deemed as high impact sports\u2019s modality, on urinary bladder (UB) and tissue remodeling. Healing of tissue depends on the equilibrium of metalloproteinases (MMPs) and their inhibitors (TIMPS). We aimed to investigate the histomorphological effects of URT on UB wall. Twelve female Wistar rats were randomly divided in two groups: sedentary (SED, <jats:italic>n<\/jats:italic> = 5) and URT (<jats:italic>n<\/jats:italic> = 7). URT was performed with a ladder climbing equipment after the maximum loaded carrying test (MLCT) was carried out. The training sessions were organized in three blocks increasing the MLCT\u2019s weight each block. New MLCT were set at the end of each block. The day after the last training, the rat was euthanized and the UB was harvested and stored in formalin for later histological analysis stained with hematoxylin-eosin (HE), Masson\u2019s trichrome (MT), picrosirius-hematoxylin (PH) and resorcin-fuchsin (RF), and immunohistochemistry for metalloproteinase-1 (MMP1) and tissue inhibitor of metalloproteinase (TIMP1). UB slices of URT rats stained with HE showed changes in all UB layers, with increased thickeness of the urothelium. MT staining allowed to observe an increased collagen concentration on the lamina propria layer (LP) of URT rats. PH staining demonstrated a higher luminous intensity for collagen type I and III in lamina propria and smooth muscle layers of the UB wall in the URT group than in SED. RF staining demonstrated an increase of elastic fiber concentration on the LP and smooth muscle layer of the bladder wall in the URT group. Immunohistochemistry of UB slices showed that MMP1 and TIMP1 were immunolabeled on the LP the UB wall in URT rats, with TIMP1 showing a lighter labeling than MMP1. Therefore, the findings suggest that URT induces remodeling of the urinary bladder wall characterized by imbalance between MMP1 and TIMP1 and evoking an alteration in the connective tissue from loose to dense.<\/jats:p>","DOI":"10.7717\/peerj.19172","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T08:30:43Z","timestamp":1743409843000},"page":"e19172","source":"Crossref","is-referenced-by-count":0,"title":["The urinary bladder wall is remodeled by undulatory resistance training in female Wistar rats"],"prefix":"10.7717","volume":"13","author":[{"given":"Amyr","family":"Braverman","sequence":"first","affiliation":[{"name":"Department of Morphology and Physiology, Centro Universitario FMABC, Santo Andre, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuha A.","family":"Dsouki","sequence":"additional","affiliation":[{"name":"Department of Morphology and Physiology, Centro Universitario FMABC, Santo Andre, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana M.","family":"Veridiano","sequence":"additional","affiliation":[{"name":"Department of Morphology and Physiology, Centro Universitario FMABC, Santo Andre, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos R. 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