{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:53:16Z","timestamp":1769388796721,"version":"3.49.0"},"reference-count":14,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Intracranial pressure increases due to ischemic infarction caused by stroke. This study aimed to evaluate the pre-thrombolytic and post-thrombolytic optic nerve sheath diameter (ONSD) measurements in predicting clinical outcomes and complications for stroke patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>ONSD was measured on computed tomography (CT) scans. The average ONSD (aONSD) was calculated from the right and left eyes. Pre-thrombolytic (ONSD-0) and post-thrombolytic (ONSD-24) values were compared according to right <jats:italic>vs<\/jats:italic> left eye, stroke-affected side of the brain, presence of complications, and mortality.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Ninety-three patients were enrolled; 52.7% were female, and the mean age of all participants was 76 years. The aONSD-24 values were higher than the aONSD-0 values (5.5 \u00b1 0.7 mm and 5.3 \u00b1 0.7 mm, respectively, <jats:italic>p<\/jats:italic> &lt; 0.001). There was no significant difference between right and left measurements (right ONSD-0 5.3 mm <jats:italic>vs<\/jats:italic>. left ONSD-0 5.3 mm, <jats:italic>p<\/jats:italic> = 0.257; right ONSD-24 5.6 mm <jats:italic>vs<\/jats:italic>. left ONSD-24 5.5 mm, <jats:italic>p<\/jats:italic> = 0.146; and \u2206right ONSD 0.23 mm <jats:italic>vs<\/jats:italic>. \u2206left ONSD 0.22, <jats:italic>p<\/jats:italic> = 0.717) and between the stroke-affected side and non-stroke-affected side measurements (stroke-affected ONSD-0 5.2 mm <jats:italic>vs<\/jats:italic>. non-stroke-affected ONSD-0 5.2 mm, <jats:italic>p<\/jats:italic> = 0.292; stroke-affected ONSD-24 5.5 mm <jats:italic>vs<\/jats:italic>. non-stroke-affected ONSD-24 5.4 mm, <jats:italic>p<\/jats:italic> = 0.124; and \u2206stroke-affected ONSD 0.23 mm <jats:italic>vs<\/jats:italic>. non-\u2206stroke-affected ONSD 0.23 mm, <jats:italic>p<\/jats:italic> = 0.569). Intracranial complications occurred in 14 (15%) patients. There was no difference in ONSD values between patients with and without complications (<jats:italic>p<\/jats:italic> = 0.338 for aONSD-0, <jats:italic>p<\/jats:italic> = 0.216 for aONSD-24, and <jats:italic>p<\/jats:italic> = 0.902 for \u2206a ONSD). There was no significant difference between the aONSD-0 and aONSD-24 values of surviving and non-surviving patients (aONSD-0: 5.3 \u00b1 0.7 <jats:italic>vs<\/jats:italic>. 5.0 \u00b1 0.5, <jats:italic>p<\/jats:italic> = 0.345; aONSD-24: 5.5 \u00b1 0.7 <jats:italic>vs<\/jats:italic>. 5.3 \u00b1 0.4, <jats:italic>p<\/jats:italic> = 0.522; and <jats:italic>p<\/jats:italic> = 0.386 for \u2206 aONSD).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>ONSD values on 24-h brain CT scans were higher than admission values in acute stroke patients receiving thrombolytic therapy, irrespective of the right or left side, stroke-affected side, presence of complications, and mortality. However, ONSD is not a sufficient parameter for predicting complications and death.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.19197","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T09:12:11Z","timestamp":1743412331000},"page":"e19197","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of optic nerve sheath diameter in acute stroke: pre- and post-thrombolytic assessment"],"prefix":"10.7717","volume":"13","author":[{"given":"Erdem","family":"Sivas","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Mardin Public Hospital, Mardin, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-9031","authenticated-orcid":true,"given":"Nese","family":"Colak","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Health Sciences Turkey, Izmir, 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