{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:53:53Z","timestamp":1791500033379,"version":"4.3.4"},"reference-count":56,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970605"],"award-info":[{"award-number":["81970605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Cisplatin-induced acute kidney injury (cis-AKI) is not rare in oncological patients clinically, but there are limited prevention and treatment methods available. The efficacy of hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) in mitigating cis-AKI has been studied and determined in animal models.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>According to the pre-registered program (PROSPERO: CRD 42023463779), we searched PubMed\/Medline, Embase, and Web of Science databases using the keywords: hydrogen sulfide, cisplatin, acute kidney injury, and alternatives. A total of 13 articles met the inclusion criteria were included. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated and aggregated using random effects meta-analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The results showed that H<jats:sub>2<\/jats:sub>S treatment significantly improved renal function (serum creatinine SMD = \u22122.96, 95% CI [\u22123.72 to \u22122.19], <jats:italic>p<\/jats:italic> &lt; 0.00001; blood urea nitrogen SMD = \u22122.73, 95% CI [\u22123.68 to \u22121.78], <jats:italic>p<\/jats:italic> &lt; 0.00001), decreased oxidative stress (superoxide dismutase SMD = 2.90, 95% CI [1.36\u20134.43], <jats:italic>p<\/jats:italic> = 0.0002) and inflammation levels (interleukin-1\u03b2 SMD = \u22124.41, 95% CI [\u22125.84 to \u22122.97], <jats:italic>p<\/jats:italic> &lt; 0.00001). However, there was a high degree of heterogeneity between studies (I<jats:sup>2<\/jats:sup> &gt; 70%). Further subgroup analysis did not show a clear source of the heterogeneity, but various H<jats:sub>2<\/jats:sub>S donors exhibited positive renal protection in those studies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>H<jats:sub>2<\/jats:sub>S could be a new approach for treating cis-AKI, while the differential efficacies among natural and slow-release H<jats:sub>2<\/jats:sub>S donors remain to be compared and evaluated further. This meta-analysis may shed light on establishing preclinical and clinical investigation guidelines for treating human cis-AKI with H<jats:sub>2<\/jats:sub>S donors.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.19481","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:48:39Z","timestamp":1747903719000},"page":"e19481","source":"Crossref","is-referenced-by-count":3,"title":["Hydrogen sulfide protects against cisplatin-induced experimental nephrotoxicity in animal models: a systematic review and meta-analysis"],"prefix":"10.7717","volume":"13","author":[{"given":"Zhenyuan","family":"Han","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"The Core Laboratory for Clinical Research, Nanjing BenQ Medical Center, Nanjing Medical University, Nanjing, 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Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"The Core Laboratory for Clinical Research, Nanjing BenQ Medical Center, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China"},{"name":"Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-5008","authenticated-orcid":true,"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"The Core Laboratory for Clinical Research, 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