{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T09:10:09Z","timestamp":1750929009541,"version":"3.41.0"},"reference-count":20,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81870062"],"award-info":[{"award-number":["No. 81870062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The National Nature Youth Foundation","award":["No. 81900038"],"award-info":[{"award-number":["No. 81900038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Circular RNA (circRNA) is a prominent group of non-coding RNA (ncRNA) that regulates gene expression at the post-transcriptional level in various diseases including acute respiratory distress syndrome (ARDS). In our study, circVAMP3 was a novel circRNA significantly increased in macrophages in an acute lung injury (ALI) model. Through knockdown and overexpression of circVAMP3, we found circVAMP3 promoted the expression of IFN-\u03b2 in macrophages, which was vital in the pathophysiological process of ARDS. Moreover, we showed that circVAMP3 targeted Stimulator of Interferon Genes (STING) through miR-580-3p by bioinformatics analysis and intervene of miR-580-3p. CircVAMP3 acts as a pro-inflammation ncRNA by regulating the miR-580-3p\/STING\/IFN-\u03b2 axis and could be a potential biomarker and therapeutic target for ARDS.<\/jats:p>","DOI":"10.7717\/peerj.19573","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T08:40:23Z","timestamp":1750927223000},"page":"e19573","source":"Crossref","is-referenced-by-count":0,"title":["CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p\/STING\/IFN-\u03b2 axis in macrophages"],"prefix":"10.7717","volume":"13","author":[{"given":"Zheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai,  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