{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:08:46Z","timestamp":1751429326722,"version":"3.41.0"},"reference-count":35,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Senior Medical Talents Program of Chongqing for Young and Middle-aged"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Postoperative nausea and vomiting (PONV) frequently occur in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) under general anesthesia. Glycopyrronium bromide, an anticholinergic medication, is believed to not only relieve gastrointestinal spasms but also effectively prevent PONV.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Objective<\/jats:title>\n               <jats:p>To compare the incidence of nausea and vomiting and the effect of relieving spasm between patients administered glycopyrronium bromide and those given anisodamine hydrobromide following endoscopic retrograde cholangiopancreatography (ERCP).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Design<\/jats:title>\n               <jats:p>This is a monocentric prospective study.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>Patients eligible for ERCP were randomly assigned to two groups. One group received 0.2 mg glycopyrronium bromide (Group G) intravenously, while the other group received 10 mg anisodamine hydrobromide (Group A) intramuscularly for anesthesia induction. The study assessed duodenal motility during ERCP and the incidence of PONV within 24 hours.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>The study included 130 patients. Nausea and vomiting within 24 hours post-surgery occurred in nine patients (13.8%) in Group G and 19 patients (29.2%) in Group A, with statistical significance (relative risk (RR), 0.47; 95% confidence interval (CI) [0.02\u20130.29]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033). Vomiting specifically was observed in three patients (4.6%) in Group G and 12 patients (18.5%) in Group A, showing statistical significance (RR 0.25; 95% CI [0.03\u20130.25]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.028). There was no significant difference in duodenal peristalsis between the groups (Group G: 10.9\u00a0\u00b1\u00a03.1 times\/min; Group A: 11.6\u00a0\u00b1\u00a03.1 times\/min; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.174).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>For patients undergoing ERCP under general anesthesia, a subcutaneous injection of 0.2 mg glycopyrronium bromide significantly reduces PONV and provides similar anti-spasmodic effects to 10 mg intramuscular anisodamine hydrobromide.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.19582","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:05:48Z","timestamp":1751357148000},"page":"e19582","source":"Crossref","is-referenced-by-count":0,"title":["Effects of glycopyrronium bromide versus anisodamine hydrobromide in preventing nausea and vomiting and relieving spasm after ERCP: a randomized controlled trial"],"prefix":"10.7717","volume":"13","author":[{"given":"Qingjing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmu","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyou","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guizhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"10.7717\/peerj.19582\/ref-1","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1016\/j.clinthera.2010.11.014","article-title":"Transdermal scopolamine for the prevention of postoperative nausea and vomiting: a systematic review and meta-analysis","volume":"32","author":"Apfel","year":"2010","journal-title":"Clinical Therapeutics"},{"key":"10.7717\/peerj.19582\/ref-2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.bja.2023.03.012","article-title":"Consensus guidelines for the perioperative management of patients undergoing endoscopic retrograde cholangiopancreatography","volume":"130","author":"Azimaraghi","year":"2023","journal-title":"British Journal of Anaesthesia"},{"key":"10.7717\/peerj.19582\/ref-3","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s40265-021-01518-w","article-title":"Indacaterol\/Glycopyrronium\/Mometasone: a review in asthma","volume":"81","author":"Blair","year":"2021","journal-title":"Drugs"},{"key":"10.7717\/peerj.19582\/ref-4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0031-6997(24)01362-0","article-title":"International Union of Pharmacology. 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