{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:36:13Z","timestamp":1786390573723,"version":"build-2736575974"},"reference-count":49,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072134"],"award-info":[{"award-number":["82072134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Fund of Anhui Institute of Translational Medicine","award":["2023zhyx-C64"],"award-info":[{"award-number":["2023zhyx-C64"]}]},{"name":"Research Fund of Anhui Institute of Translational Medicine","award":["2022zhyx-C76"],"award-info":[{"award-number":["2022zhyx-C76"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Sepsis is a life-threatening condition characterized by systemic inflammation and dysfunction of multiple organs. Recently, regulatory cell death (RCD) has emerged as a distinct pathological feature and serve as a potential source of biomarkers or therapeutic targets in sepsis.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>Comprehensive transcriptomic datasets of sepsis were accessed from the Gene Expression Omnibus (GEO) database. Genes involved in 18 RCD pathways were compiled from databases and published literature. The limma package was utilized to identify differentially expressed genes (DEGs). The Gene Set Variation Analysis (GSVA), CIBERSORT, Weighted Gene Co-expression Network Analysis (WGCNA), and receiver operating characteristic (ROC) analyses were combined to identify key RCDs pathways. Core RCD-related DEGs (RRDs) were selected using Least Absolute Shrinkage and Selection Operator (LASSO), Support Vector Machine (SVM), and Random Forest (RF) machine learning methods. The expression patterns and diagnostic performance of the core RRDs were validated across multiple datasets and further confirmed through meta-analysis. Immune localization of RRDs was examined using single-cell transcriptomic data. Prognostic significance was evaluated using multivariate Cox analysis. Finally, the mRNA expression level was validated using quantitative real-time polymerase chain reaction (qRT-PCR).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>Zinc Finger DHHC-Type Containing 3 (ZDHHC3), Chloride Intracellular Channel 1 (CLIC1), Glutathione S-Transferase Omega 1 (GSTO1), Biogenesis of Lysosomal Organelles Complex 1 Subunit 1 (BLOC1S1), and Toll-Like Receptor 5 (TLR5) were considered as core RRDs, with monocytes and neutrophils serving as the principal cell types responsible for their overexpression and likely contributing critically to their downstream biological effects. Among them, ZDHHC3 and TLR5 were identified as independent risk factors for sepsis. Their significantly elevated mRNA expression in septic mice was confirmed by qRT-PCR.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>Findings from this study underscored the crucial role of RCD pathways in the development of sepsis. Notably, ZDHHC3 and TLR5 were identified as novel and robust biomarkers for sepsis.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.20167","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T08:37:50Z","timestamp":1760431070000},"page":"e20167","source":"Crossref","is-referenced-by-count":2,"title":["Unraveling the role of regulatory cell death in sepsis: an integrated analysis of bulk and single-cell sequencing data"],"prefix":"10.7717","volume":"13","author":[{"given":"Susu","family":"Cao","sequence":"first","affiliation":[{"name":"Anhui Medical University, Hefei, China"},{"name":"The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Laboratory of Cardiopulmonary Resuscitation and Critical Care, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Anhui Medical University, Hefei, China"},{"name":"The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Laboratory of Cardiopulmonary Resuscitation and Critical Care, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinong","family":"Pan","sequence":"additional","affiliation":[{"name":"Anhui Medical University, Hefei, China"},{"name":"The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Laboratory of Cardiopulmonary Resuscitation and Critical Care, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Medical University, Hefei, China"},{"name":"The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Laboratory of Cardiopulmonary Resuscitation and Critical Care, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Hua","sequence":"additional","affiliation":[{"name":"Anhui Medical University, Hefei, China"},{"name":"The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Laboratory of Cardiopulmonary Resuscitation and Critical Care, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Anhui Medical University, Hefei, China"},{"name":"The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Laboratory of Cardiopulmonary Resuscitation and Critical Care, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"10.7717\/peerj.20167\/ref-1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling tumor infiltrating immune cells with CIBERSORT","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods in Molecular Biology"},{"issue":"4","key":"10.7717\/peerj.20167\/ref-2","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del\u00a0Re","year":"2019","journal-title":"Physiological Reviews"},{"key":"10.7717\/peerj.20167\/ref-3","doi-asserted-by":"publisher","first-page":"6370911","DOI":"10.1155\/2021\/6370911","article-title":"IL-38 alleviates inflammation in sepsis in mice by inhibiting macrophage apoptosis and activation of the NLRP3 inflammasome","volume":"2021","author":"Ge","year":"2021","journal-title":"Mediators of Inflammation"},{"key":"10.7717\/peerj.20167\/ref-4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"12","key":"10.7717\/peerj.20167\/ref-5","doi-asserted-by":"publisher","first-page":"5524","DOI":"10.1128\/IAI.00843-08","article-title":"Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kappaB activation","volume":"76","author":"Harrison","year":"2008","journal-title":"Infection and Immunity"},{"issue":"5","key":"10.7717\/peerj.20167\/ref-6","doi-asserted-by":"publisher","first-page":"e2412895","DOI":"10.1002\/advs.202412895","article-title":"Palmitic acid accelerates endothelial cell injury and cardiovascular dysfunction via palmitoylation of PKM2","volume":"12","author":"He","year":"2025","journal-title":"Advanced Science"},{"issue":"2","key":"10.7717\/peerj.20167\/ref-7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","article-title":"Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway","volume":"19","author":"Holze","year":"2018","journal-title":"Nature Immunology"},{"issue":"11","key":"10.7717\/peerj.20167\/ref-8","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1002\/tox.24377","article-title":"Lipopolysaccharide-induced lysosomal cell death through reactive oxygen species in rat liver cell clone 9","volume":"39","author":"Hsu","year":"2024","journal-title":"Environmental Toxicology"},{"issue":"4","key":"10.7717\/peerj.20167\/ref-9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41419-020-2476-2","article-title":"Chemotherapy-induced pyroptosis is mediated by BAK\/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death & Disease"},{"issue":"1","key":"10.7717\/peerj.20167\/ref-10","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12974-022-02598-5","article-title":"Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1\u03b1\/Xbp1s-Ca2+ axis","volume":"19","author":"Jing","year":"2022","journal-title":"Journal of Neuroinflammation"},{"issue":"3","key":"10.7717\/peerj.20167\/ref-11","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1002\/jcb.26363","article-title":"Anoikis resistance and oncoviruses","volume":"119","author":"Kakavandi","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"issue":"D1","key":"10.7717\/peerj.20167\/ref-12","doi-asserted-by":"publisher","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Research"},{"key":"10.7717\/peerj.20167\/ref-13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"10.7717\/peerj.20167\/ref-14","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"issue":"2","key":"10.7717\/peerj.20167\/ref-15","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.molcel.2019.09.006","article-title":"The diversification of cell death and immunity: memento mori","volume":"76","author":"Legrand","year":"2019","journal-title":"Molecular Cell"},{"key":"10.7717\/peerj.20167\/ref-16","doi-asserted-by":"publisher","first-page":"1152186","DOI":"10.3389\/fimmu.2023.1152186","article-title":"Bioinformatics and system biology approach to identify the influences among COVID-19, ARDS and sepsis","volume":"14","author":"Li","year":"2023","journal-title":"Frontiers in Immunology"},{"issue":"5","key":"10.7717\/peerj.20167\/ref-17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1080\/1040841X.2021.1915959","article-title":"Inhibition of Streptococcus mutans biofilm formation by strategies targeting the metabolism of exopolysaccharides","volume":"47","author":"Lin","year":"2021","journal-title":"Critical Reviews in Microbiology"},{"issue":"9","key":"10.7717\/peerj.20167\/ref-18","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1038\/s41418-020-0536-x","article-title":"HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1\u03b1-dependent acyloxyacyl hydrolase expression","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Death and Differentiation"},{"issue":"21","key":"10.7717\/peerj.20167\/ref-19","doi-asserted-by":"publisher","first-page":"11415","DOI":"10.3390\/ijms252111415","article-title":"2-bromopalmitate-induced intestinal flora changes and testicular dysfunction in mice","volume":"25","author":"Ma","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.7717\/peerj.20167\/ref-20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/sj.cdd.4400616","article-title":"The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly","volume":"7","author":"Matarrese","year":"2000","journal-title":"Cell Death and Differentiation"},{"issue":"2","key":"10.7717\/peerj.20167\/ref-21","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1093\/bib\/bbaa038","article-title":"GPS-Palm: a deep learning-based graphic presentation system for the prediction of S-palmitoylation sites in proteins","volume":"22","author":"Ning","year":"2021","journal-title":"Briefings in Bioinformatics"},{"issue":"8","key":"10.7717\/peerj.20167\/ref-22","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/s41419-022-05145-5","article-title":"OTUD1 deubiquitinase regulates NF-\u03baB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways","volume":"13","author":"Oikawa","year":"2022","journal-title":"Cell Death & Disease"},{"issue":"11","key":"10.7717\/peerj.20167\/ref-23","doi-asserted-by":"publisher","first-page":"R127","DOI":"10.1186\/gb-2009-10-11-r127","article-title":"Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis","volume":"10","author":"Pankla","year":"2009","journal-title":"Genome Biology"},{"issue":"6","key":"10.7717\/peerj.20167\/ref-24","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1002\/JLB.5MA0721-825R","article-title":"Dynamic changes in human single-cell transcriptional signatures during fatal sepsis","volume":"110","author":"Qiu","year":"2021","journal-title":"Journal of Leukocyte Biology"},{"issue":"7","key":"10.7717\/peerj.20167\/ref-25","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1164\/rccm.201502-0355OC","article-title":"A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission","volume":"192","author":"Scicluna","year":"2015","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"9","key":"10.7717\/peerj.20167\/ref-26","doi-asserted-by":"publisher","first-page":"110638","DOI":"10.1016\/j.isci.2024.110638","article-title":"GRP94 promotes anoikis resistance and peritoneal metastasis through YAP\/TEAD1 pathway in gastric cancer","volume":"27","author":"Shi","year":"2024","journal-title":"IScience"},{"issue":"5","key":"10.7717\/peerj.20167\/ref-27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1590\/1414-431x20143190","article-title":"Evaluation of toll-like, chemokine, and integrin receptors on monocytes and neutrophils from peripheral blood of septic patients and their correlation with clinical outcomes","volume":"47","author":"Silva","year":"2014","journal-title":"Brazilian Journal of Medical and Biological Research"},{"issue":"5","key":"10.7717\/peerj.20167\/ref-28","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.3390\/ijms26052274","article-title":"The novel role of the expression of toll-like receptors TLR-5, TLR-6, and TLR-9 and associated up-regulation of programmed cell death 1 receptor (PD-1) and its ligand (PD-L1) in lung sepsis","volume":"26","author":"Sinos","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.7717\/peerj.20167\/ref-29","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1038\/s41467-017-02221-9","article-title":"Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a","volume":"8","author":"Spinelli","year":"2017","journal-title":"Nature Communications"},{"issue":"3","key":"10.7717\/peerj.20167\/ref-30","doi-asserted-by":"publisher","first-page":"R149","DOI":"10.1186\/cc10274","article-title":"Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis","volume":"15","author":"Sutherland","year":"2011","journal-title":"Critical Care"},{"key":"10.7717\/peerj.20167\/ref-31","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.3389\/fimmu.2018.03091","article-title":"Endogenous retroviruses transcriptional modulation after severe infection, trauma and burn","volume":"9","author":"Tabone","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"10.7717\/peerj.20167\/ref-32","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/path.3000","article-title":"Anoikis: an emerging hallmark in health and diseases","volume":"226","author":"Taddei","year":"2012","journal-title":"Journal of Pathology"},{"issue":"D1","key":"10.7717\/peerj.20167\/ref-33","doi-asserted-by":"publisher","first-page":"D330","DOI":"10.1093\/nar\/gky1055","article-title":"The gene ontology resource: 20 years and still going strong","volume":"47","author":"The Gene Ontology\u00a0Consortium","year":"2019","journal-title":"Nucleic Acids Research"},{"key":"10.7717\/peerj.20167\/ref-34","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit","volume":"2","author":"Vincent","year":"2014","journal-title":"The Lancet Respiratory Medicine"},{"issue":"9868","key":"10.7717\/peerj.20167\/ref-35","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/S0140-6736(12)61815-7","article-title":"Sepsis definitions: time for change","volume":"381","author":"Vincent","year":"2013","journal-title":"Lancet"},{"issue":"9","key":"10.7717\/peerj.20167\/ref-36","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1182\/blood.2020009417","article-title":"Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis","volume":"138","author":"Wang","year":"2021","journal-title":"Blood"},{"issue":"5","key":"10.7717\/peerj.20167\/ref-37","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1097\/CCM.0b013e31819fcc08","article-title":"Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum","volume":"37","author":"Wong","year":"2009","journal-title":"Critical Care Medicine"},{"key":"10.7717\/peerj.20167\/ref-38","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1741-7015-7-34","article-title":"Identification of pediatric septic shock subclasses based on genome-wide expression profiling","volume":"7","author":"Wong","year":"2009","journal-title":"BMC Medicine"},{"issue":"11\u201312","key":"10.7717\/peerj.20167\/ref-39","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.2119\/molmed.2011.00169","article-title":"The influence of developmental age on the early transcriptomic response of children with septic shock","volume":"17","author":"Wynn","year":"2011","journal-title":"Missouri Medicine"},{"issue":"28","key":"10.7717\/peerj.20167\/ref-40","doi-asserted-by":"publisher","first-page":"e2302130","DOI":"10.1002\/advs.202302130","article-title":"Palmitoyltransferase ZDHHC3 aggravates nonalcoholic steatohepatitis by targeting s-palmitoylated IRHOM2","volume":"10","author":"Xu","year":"2023","journal-title":"Advanced Science (Weinh)"},{"key":"10.7717\/peerj.20167\/ref-41","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.cbi.2018.11.026","article-title":"TLR5 silencing reduced hyperammonaemia-induced liver injury by inhibiting oxidative stress and inflammation responses via inactivating NF-\u03baB and MAPK signals","volume":"299","author":"Yan","year":"2019","journal-title":"Chemico-Biological Interactions"},{"issue":"6","key":"10.7717\/peerj.20167\/ref-42","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1109\/TCBB.2021.3107874","article-title":"A robust and generalizable immune-related signature for sepsis diagnostics","volume":"19","author":"Yang","year":"2022","journal-title":"IEEE Transactions on Computational Biology and Bioinformatics"},{"issue":"4","key":"10.7717\/peerj.20167\/ref-43","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41551-019-0375-6","article-title":"Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours [published correction appears in Nat Biomed Eng. 2019 May;3(5):414. DOI: 10.1038\/s41551-019-0402-7]","volume":"3","author":"Yao","year":"2019","journal-title":"Nature Biomedical Engineering"},{"issue":"4","key":"10.7717\/peerj.20167\/ref-44","doi-asserted-by":"publisher","first-page":"114070","DOI":"10.1016\/j.celrep.2024.114070","article-title":"NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation","volume":"43","author":"Yu","year":"2024","journal-title":"Cell Reports"},{"issue":"5","key":"10.7717\/peerj.20167\/ref-45","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.7717\/peerj.20167\/ref-46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.lfs.2018.11.055","article-title":"Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice","volume":"217","author":"Zhang","year":"2019","journal-title":"Life Sciences"},{"issue":"7829","key":"10.7717\/peerj.20167\/ref-47","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41586-020-2799-2","article-title":"A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis","volume":"586","author":"Zhang","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.7717\/peerj.20167\/ref-48","doi-asserted-by":"publisher","first-page":"464","DOI":"10.7150\/ijbs.86424","article-title":"ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21\/A20 signaling","volume":"20","author":"Zhao","year":"2024","journal-title":"International Journal of Biological Sciences"},{"key":"10.7717\/peerj.20167\/ref-49","doi-asserted-by":"publisher","first-page":"106936","DOI":"10.1016\/j.ijsu.2022.106936","article-title":"Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery","volume":"107","author":"Zou","year":"2022","journal-title":"International Journal of Surgery"}],"container-title":["PeerJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/peerj.com\/articles\/20167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/20167.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/20167.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/20167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T08:37:53Z","timestamp":1760431073000},"score":1,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/20167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":49,"alternative-id":["10.7717\/peerj.20167"],"URL":"https:\/\/doi.org\/10.7717\/peerj.20167","archive":["CLOCKSS","LOCKSS","Portico"],"relation":{},"ISSN":["2167-8359"],"issn-type":[{"value":"2167-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"article-number":"e20167"}}