{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:50:59Z","timestamp":1769694659080,"version":"3.49.0"},"reference-count":61,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Province General University Characteristic Innovation Project","award":["2021KTSCX034"],"award-info":[{"award-number":["2021KTSCX034"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2022A1515012299"],"award-info":[{"award-number":["2022A1515012299"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Long non-coding RNAs (lncRNAs) constitute a large class of ribonucleic acids, participating in multiple biological events within tumor cells, especially the regulation of transcription. A growing body of literature has revealed that abnormalities of lncRNA expression could result in carcinogenesis and oncogenesis by exerting inhibition or oncogenic effects. LINC01094 is a recently identified lncRNA found to be dys-regulated in an assortment of cancer tissues and control multiple biological processes via competing endogenous RNA (ceRNA) mechanisms. Specifically, LINC01094 functions as a ceRNA to modulate tumor cell growth, invasion, and migration by regulating critical signaling pathways including PI3K\/AKT, PTEN\/AKT, and Wnt\/\u03b2-catenin, while also exerting oncogenic effects through transcriptional regulatory networks. Numerous recently published reports have shown that LINC01094 exerts critical functions during the regulation of malignant cell growth, migrating ability, and invasiveness, thereby controlling cancer cell growth and metastasis. In this review, multiple cancer biology functions of LINC01094 documented in published literature are summarized, aiming to inspire innovations in the management of human malignancies under laboratory and clinical settings.<\/jats:p>","DOI":"10.7717\/peerj.20621","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:36:28Z","timestamp":1769502988000},"page":"e20621","source":"Crossref","is-referenced-by-count":0,"title":["Implications of LINC01094 for human malignancies"],"prefix":"10.7717","volume":"14","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang, Guangdong, China"},{"name":"Key Laboratory of Liver Injury Diagnosis and Repair and Department of Hepatobiliary Surgery, The 2nd Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang, Guangdong, China"},{"name":"School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang, Guangdong, China"},{"name":"School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zeng","sequence":"additional","affiliation":[{"name":"Cancer Hospital of The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Cai","sequence":"additional","affiliation":[{"name":"Cancer Hospital of The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqing","family":"Luo","sequence":"additional","affiliation":[{"name":"Cancer Hospital of The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"1","key":"10.7717\/peerj.20621\/ref-1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrc.2017.99","article-title":"Non-coding RNA networks in cancer","volume":"18","author":"Anastasiadou","year":"2018","journal-title":"Nature Reviews Cancer"},{"issue":"2","key":"10.7717\/peerj.20621\/ref-2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.6004\/jnccn.2021.0007","article-title":"Ovarian cancer, version 2.2020, NCCN clinical practice guidelines in oncology","volume":"19","author":"Armstrong","year":"2021","journal-title":"Journal of the National Comprehensive Cancer Network: JNCCN"},{"issue":"5","key":"10.7717\/peerj.20621\/ref-3","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1097\/JS9.0000000000002349","article-title":"Identification of biomarkers of shrinkage modes after neoadjuvant therapy in HER-2 positive breast cancer","volume":"111","author":"Bi","year":"2025","journal-title":"International Journal of Surgery"},{"key":"10.7717\/peerj.20621\/ref-4","doi-asserted-by":"publisher","first-page":"9845","DOI":"10.2147\/CMAR.S265196","article-title":"miR-144-3p contributes to the development of thyroid tumors through the PTEN\/PI3K\/AKT Pathway","volume":"12","author":"Cao","year":"2020","journal-title":"Cancer Management and Research"},{"issue":"8","key":"10.7717\/peerj.20621\/ref-5","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41576-024-00693-2","article-title":"Targeting and engineering long non-coding RNAs for cancer therapy","volume":"25","author":"Coan","year":"2024","journal-title":"Nature Reviews. 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