{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:10:23Z","timestamp":1772637023705,"version":"3.50.1"},"reference-count":59,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Guangdong S&T Program","award":["2023B1111030006"],"award-info":[{"award-number":["2023B1111030006"]}]},{"name":"Huadu District Basic and Applied Basic Research Joint Funding Project (District-Hospital Collaboration), Guangzhou","award":["23HDQYLH08"],"award-info":[{"award-number":["23HDQYLH08"]}]},{"name":"Guangzhou Health Technology Project","award":["20241A011112"],"award-info":[{"award-number":["20241A011112"]}]},{"name":"Guangzhou Medical Key Subject Construction Project","award":["2025\u20132027"],"award-info":[{"award-number":["2025\u20132027"]}]},{"name":"Huadu District People\u2019s Hospital of Guangzhou Internal Research Fund Project","award":["2022C01"],"award-info":[{"award-number":["2022C01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Neuro-immune interactions are critical in cancer, yet their molecular features in bladder cancer remain unclear. We analyzed transcriptomic data from TCGA and UCSC Xena to investigate the expression profiles and molecular subtypes of neuro-immune\u2013related genes, and constructed a neuro-immune\u2013related score (NAS) model. Single-cell transcriptomic data were integrated to explore the immune microenvironmental features, and functional validation was performed by knocking down SERPINE2 with shRNA in T24 cells. The results showed that six core genes (SERPINE2, NXPH4, SERPINB2, C2orf40, SERPINB12, SERPINB10) were identified to stratify patients into high- and low-risk groups, with robust predictive power across clinical subgroups and validation cohorts. Single-cell RNA-seq data revealed significant NAS heterogeneity among cell populations. The NAS-high state was enriched in TGF\u03b2, EGF, and FGF signaling with activation of EZH2 and SMARCA4, while the NAS-low state showed immune-regulatory features. Functional assays confirmed that SERPINE2 knockdown suppressed proliferation, migration, invasion, while increasing apoptosis of T24 cells, highlighting its oncogenic role. Moreover, genome-wide association studies (GWAS) suggested that genetic variants in SERPINE2 and related genes may increase bladder cancer susceptibility. Collectively, our findings provide novel insights into neuro-immune\u2013driven tumor heterogeneity and immune remodeling, establish the NAS model as an innovative prognostic tool, and identify SERPINE2 as a promising therapeutic target for precision management of bladder cancer.<\/jats:p>","DOI":"10.7717\/peerj.20917","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:51:03Z","timestamp":1772614263000},"page":"e20917","source":"Crossref","is-referenced-by-count":0,"title":["Neuro-immune\u2013related gene signatures define molecular subtypes and prognostic score in bladder cancer with SERPINE2 as a potential therapeutic target"],"prefix":"10.7717","volume":"14","author":[{"given":"Qiwei","family":"Nie","sequence":"first","affiliation":[{"name":"School of Medicine, Jinan University, Guangzhou, China"},{"name":"Department of Urology, Zhuhai People\u2019s Hospital, Zhuhai, China"},{"name":"Department of Urology, Guangdong Key Laboratory of Clinical 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