{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:13:08Z","timestamp":1775725988334,"version":"3.50.1"},"reference-count":52,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The financial support of the project of the Ministry of Higher Education and Science of the Russian Federation","award":["FZZE 2024-0011"],"award-info":[{"award-number":["FZZE 2024-0011"]}]},{"name":"The financial support of the project of the Ministry of Higher Education and Science of the Russian Federation","award":["FZZE 2024-0003"],"award-info":[{"award-number":["FZZE 2024-0003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Pharmaceutical pollutants, including ibuprofen, are now ubiquitously detected in global aquatic ecosystems, exerting significant negative ecological impacts. Lake Baikal organisms have been documented to accumulate ibuprofen and related contaminants. This study quantified ibuprofen concentrations within Lake Baikal\u2019s endemic amphipod fauna using high-performance liquid chromatography coupled with mass spectrometry. We analyzed specimens representing key ecological groups across the genera\n                    <jats:italic>Eulimnogammarus<\/jats:italic>\n                    ,\n                    <jats:italic>Brandtia<\/jats:italic>\n                    ,\n                    <jats:italic>Ommatogammarus<\/jats:italic>\n                    , and\n                    <jats:italic>Pallasea<\/jats:italic>\n                    . Ibuprofen concentrations ranged from 4.19 ng\/g to 1,151.32 ng\/g (wet weight), confirming consistent contamination in both littoral and deep-water endemic amphipod populations. Crucially, our data provide the first evidence suggesting amphipods, or their associated symbiotic microbiota, may metabolize ibuprofen. Interspecific accumulation patterns were identified, with\n                    <jats:italic>Eulimnogammarus<\/jats:italic>\n                    sp. and\n                    <jats:italic>Brandtia<\/jats:italic>\n                    sp. exhibiting distinct profiles. Furthermore, accumulation was significantly higher during spring compared to autumn samples. A negative correlation emerged between ibuprofen concentration and amphipod body mass within species. Several populations contained non-detectable levels. These findings demonstrate that endemic amphipods within Lake Baikal\u2019s natural environment are exposed to and bioaccumulate the pharmaceutical pollutant ibuprofen, exhibiting species-specific, seasonal, and allometric variation in uptake.\n                  <\/jats:p>","DOI":"10.7717\/peerj.21008","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:23:05Z","timestamp":1775722985000},"page":"e21008","source":"Crossref","is-referenced-by-count":0,"title":["Accumulation of ibuprofen in endemic amphipods of Lake Baikal"],"prefix":"10.7717","volume":"14","author":[{"given":"Tamara Yu","family":"Telnova","sequence":"first","affiliation":[{"name":"Bioorganics Research and Educational Center, Irkutsk State University, Irkutsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Morgunova","sequence":"additional","affiliation":[{"name":"Bioorganics Research and Educational Center, Irkutsk State University, Irkutsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie S.","family":"Shashkina","sequence":"additional","affiliation":[{"name":"Bioorganics Research and Educational Center, Irkutsk State University, Irkutsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Dmitrieva","sequence":"additional","affiliation":[{"name":"Bioorganics Research and Educational Center, Irkutsk State University, Irkutsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria N.","family":"Shelkovnikova","sequence":"additional","affiliation":[{"name":"Bioorganics Research and Educational Center, Irkutsk State University, Irkutsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga E.","family":"Lipatova","sequence":"additional","affiliation":[{"name":"Bioorganics Research and Educational Center, Irkutsk State University, Irkutsk, 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