{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:43:52Z","timestamp":1792511032613,"version":"4.5.0"},"reference-count":24,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Guangdong Province","award":["2021A0505030031"],"award-info":[{"award-number":["2021A0505030031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This retrospective study compared the effects of indobufen versus aspirin, each combined with clopidogrel, on serum uric acid (SUA) levels and gout attacks in patients undergoing coronary stenting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Among 213 enrolled patients, 156 were included after propensity score matching and assigned to either the indobufen plus clopidogrel group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a078) or the aspirin plus clopidogrel group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a078). SUA levels were measured at baseline and at the 1-month, 6-month, and 1-year follow-ups. Gout attacks and major cardiovascular events were recorded throughout the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were comparable. The indobufen group showed significant reductions in SUA levels at all follow-ups (all,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), whereas levels in the aspirin group remained stable. Although the initial gout attack rates at baseline were similar between groups, the probability of recurrence during follow-up was lower in the indobufen group. Cardiovascular safety profiles were comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Indobufen plus clopidogrel significantly reduced SUA levels and showed a favorable trend in reducing gout recurrences without compromising cardiovascular safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.21020","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:51:47Z","timestamp":1774601507000},"page":"e21020","source":"Crossref","is-referenced-by-count":1,"title":["Indobufen\n                    <i>versus<\/i>\n                    aspirin in dual antiplatelet therapy: a retrospective study of effects on serum uric acid levels and gout attacks in patients post-coronary stenting"],"prefix":"10.7717","volume":"14","author":[{"given":"Sijie","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"},{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"},{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Gong","sequence":"additional","affiliation":[{"name":"UNSW Microbiome Research Centre, St George and Sutherland Clinical Campus, University of New South Wales, Sydney, Australia"},{"name":"School of Medicine, Huaqiao University, Quanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"},{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"10.7717\/peerj.21020\/ref-1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00424-018-2229-6","article-title":"Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury","volume":"471","author":"Cao","year":"2019","journal-title":"Pflugers Archiv. 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