{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:12:51Z","timestamp":1777281171859,"version":"3.51.4"},"reference-count":84,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["13\/08028-1"],"award-info":[{"award-number":["13\/08028-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["14\/50931-1"],"award-info":[{"award-number":["14\/50931-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["16\/17392-7"],"award-info":[{"award-number":["16\/17392-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["CNPq 307426\/2021-1"],"award-info":[{"award-number":["CNPq 307426\/2021-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["CNPq\/INCT 465355\/2014-5"],"award-info":[{"award-number":["CNPq\/INCT 465355\/2014-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["CNPQ 305961\/2019-5"],"award-info":[{"award-number":["CNPQ 305961\/2019-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Non-syndromic cleft lip or palate (NS-CL\/P) is an oral birth defect with complex aetiology. We compared the microbial diversity and composition of the oral microbiome of mothers of babies with NS-CL\/P (CLP group) and mothers of babies without NS-CL\/P (control group). Oral microbiome composition was determined by sequencing the V3-V4 regions of the 16S rRNA gene. CLP and control groups had overall similar microbial compositions, but significant differences were observed. The most significant microbial genus related to these differences was\n                    <jats:italic>Cutibacterium<\/jats:italic>\n                    , which was more abundant in the CLP group. Based on the literature, we hypothesize that a member of the\n                    <jats:italic>Cutibacterium<\/jats:italic>\n                    genus present in the oral microbiota may have a role in inflammation processes that could be related to NS-CL\/P development. We found additional differences in terms of differential abundance when subsetting the dataset for mothers with a male child; in this case, depletion of\n                    <jats:italic>Limosilactobacillus<\/jats:italic>\n                    and an unknown taxon, in the CLP group, was a significant result. We conclude that the maternal oral microbiome likely plays a role in the development of the NS-CL\/P condition.\n                  <\/jats:p>","DOI":"10.7717\/peerj.21128","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T08:26:07Z","timestamp":1777278367000},"page":"e21128","source":"Crossref","is-referenced-by-count":0,"title":["The oral maternal microbiome plays a role in the development of cleft lip and palate condition in children"],"prefix":"10.7717","volume":"14","author":[{"given":"Suzana Eiko Sato","family":"Guima","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Bischain","sequence":"additional","affiliation":[{"name":"Centro de Estudos do Genoma Humano, Departamento de Gen\u00e9tica e Biologia Evolutiva, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia C.","family":"Morais Gama","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agatha Cristhina","family":"Faria","sequence":"additional","affiliation":[{"name":"Centro de Estudos do Genoma Humano, Departamento de Gen\u00e9tica e Biologia Evolutiva, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talita","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Departamento de Microbiologia M\u00e9dica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Franco","family":"Bueno","sequence":"additional","affiliation":[{"name":"Albert Einstein Israeli College of Health Sciences, Albert Einstein Hospital, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Heller","sequence":"additional","affiliation":[{"name":"UT Health San Antonio, University of Texas, San Antonio, TX, United States of America"},{"name":"Universidade Cruzeiro do Sul, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Passos-Bueno","sequence":"additional","affiliation":[{"name":"Centro de Estudos do Genoma Humano, Departamento de Gen\u00e9tica e Biologia Evolutiva, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o 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