{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:02:53Z","timestamp":1780909373493,"version":"3.54.1"},"reference-count":143,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Shandong Provincial Natural Science Foundation","award":["ZR2020MH146"],"award-info":[{"award-number":["ZR2020MH146"]}]},{"name":"Shandong Provincial Medical and Health Science and Technology Development Program","award":["202502051089"],"award-info":[{"award-number":["202502051089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta (A\u03b2) plaques, hyperphosphorylated tau tangles, and significant neuronal loss. Recent studies have implicated YKL-40, a glycoprotein commonly associated with inflammation and neural apoptosis, in the pathogenesis of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted extensive searches across major scientific databases, including PubMed, Web of Science, and Embase. We selected peer-reviewed articles, review articles, and clinical studies focusing on YKL-40 in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review comprehensively analyses the multifaceted role of YKL-40 in AD, covering its cellular localization, biomarker associations, and pathological mechanisms. We also summarize the mechanistic pathways by which YKL-40 contributes to disease progression, highlighting its role in neuroinflammation, neural apoptosis, and disruption of the circadian regulation of immune responses. Moreover, the development of drugs that target YKL-40, such as humanized anti-YKL-40 antibodies and small molecules, offers promising strategies for blocking AD progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review highlights the potential of YKL-40 as a novel drug target and its implications for enhancing diagnostic precision and treatment strategies in combating Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.21361","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:19:20Z","timestamp":1780906760000},"page":"e21361","source":"Crossref","is-referenced-by-count":0,"title":["The role of YKL-40 in Alzheimer\u2019s disease pathology and drug targeting"],"prefix":"10.7717","volume":"14","author":[{"given":"Yaru","family":"Sha","sequence":"first","affiliation":[{"name":"School of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Shandong Second Medical 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