{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:01:15Z","timestamp":1784797275703,"version":"3.55.0"},"reference-count":53,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Health Science Research Project of Sichuan Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With accelerating population aging, sarcopenia has become increasingly common in the elderly. Because the triglyceride-glucose index is correlated with sarcopenia, this study aims to investigate the association between the triglyceride-glucose index and sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Web of Science, Embase, and Cochrane Library databases was conducted for relevant studies published up to June 15, 2025. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model in STATA 15.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of 14 studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0= 82,798) revealed a significant association between the triglyceride- glucose index (TyG index) and sarcopenia (OR = 2.15, 95% CI [1.60\u20132.89]). A significant correlation was also observed in the TyG quartile groups: Q2 (OR = 1.38, 95% CI [1.08\u20131.75]), Q3 (OR = 1.64, 95% CI [1.21\u20132.20]), and Q4 (OR = 1.75, 95% CI [1.21\u20132.55]). The TyG-BMI index demonstrated a stronger association, with the strength of this association increasing significantly as the quartile level rose Q2 (OR = 2.51, 95% CI [1.55\u20134.05]); Q3 (OR = 5.01, 95% CI [1.89\u201313.25]); Q4 (OR = 9.08, 95% CI [2.91\u201328.37]). Subgroup analyses revealed that the Asian Working Group for Sarcopenia 2019 (AWGS 2019) diagnostic criteria (OR = 5.28, 95% CI [2.27\u201312.3]), middle-aged individuals (OR = 1.87, 95% CI [1.46\u20132.42]), individuals with comorbidities (OR = 1.94, 95% CI [1.54\u20132.44]), and different TyG measurement methods (OR = 2.14, 95% CI [1.24\u20133.71]) were also significantly associated with sarcopenia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis confirms a significant association between the TyG index and sarcopenia. The prevalence of sarcopenia increases with the elevation of the TyG index. This highlights the potential value of the TyG index as a key indicator for sarcopenia screening and early intervention. 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