{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:03:12Z","timestamp":1784710992033,"version":"3.55.0"},"reference-count":17,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017375","name":"Shanghai Key Laboratory of Clinical Geriatric Medicine","doi-asserted-by":"crossref","award":["2022k004"],"award-info":[{"award-number":["2022k004"]}],"id":[{"id":"10.13039\/100017375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the prognostic impact of early-onset smoking history (started smoking before 24 years old) on the survival of Chinese patients aged \u2265 80 years with diffuse large B-cell lymphoma (DLBCL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged \u2265 80 years DLBCL with smoke history admitted to our center from 2010 to 2024 were retrospectively enrolled. Patients who started smoking before 24 years old were defined as early-onset smoking group, while who started smoking after the age of &lt; 24 years old were defined as late-onset smoking group. The overall survival (OS), progression-free survival (PFS) and treatment-related complications were compared between the two groups. Cox regression model was used to analyze the prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After follow-up duration of 28.7 months, 68 patients were included. The median OS of early-onset smoking group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029) was 2.3 years, which was significantly lower than that of late-onset smoking group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a039, 3.7 years,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Multivariate analysis illuminated that late-onset smoking decreased the risk of death significantly (HR = 0.317,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.031), as well as another risk factor: ECOG &lt; 2 (HR = 0.569,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.042).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Remarkably, late-onset smoking and better performance status portended a favorable prognosis of super-aged patients with lymphoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.21557","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:33:40Z","timestamp":1784709220000},"page":"e21557","source":"Crossref","is-referenced-by-count":0,"title":["Role of late-onset smoking in super-aged patients with diffuse large B-cell lymphoma: a real-world study in China between 2010 and 2024"],"prefix":"10.7717","volume":"14","author":[{"given":"Zhan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology of Hua\u2019Dong Hospital, Shanghai Medical College, Fudan University,  Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology of Hua\u2019Dong Hospital, Shanghai Medical College, Fudan University,  Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiation of Hua\u2019Dong Hospital, Shanghai Medical College, Fudan University, Shanghai,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"10.7717\/peerj.21557\/ref-1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S2213-2600(18)30100-0","article-title":"Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life","volume":"6","author":"Bui","year":"2018","journal-title":"The Lancet Respiratory Medicine"},{"key":"10.7717\/peerj.21557\/ref-2","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1200\/JCO.2006.09.2403","article-title":"Revised response criteria for malignant lymphoma","volume":"25","author":"Cheson","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"10.7717\/peerj.21557\/ref-3","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1002\/cncr.25114","article-title":"Smoking, alcohol use, obesity, and overall survival from non-Hodgkin 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