{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:21:32Z","timestamp":1788531692681,"version":"build-2803163510"},"reference-count":31,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Deanship of Research and Graduate Studies at King Khalid University, Saudi Arabia","award":["RGP2\/443\/46"],"award-info":[{"award-number":["RGP2\/443\/46"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo, a chronic autoimmune depigmenting disorder, substantially affects patients\u2019 psychosocial well-being despite its benign physical course. Limited evidence from Saudi Arabia explores the quality-of-life (QoL) impact of vitiligo and its clinical correlates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess QoL impairment among adults with vitiligo and to determine the relationship between disease characteristics and Dermatology Life Quality Index (DLQI) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional, questionnaire-based study was conducted among 121 adults attending a tertiary dermatology center in Saudi Arabia. Data on sociodemographic and clinical variables were collected, and QoL was evaluated using the validated DLQI instrument (Arabic\/English). Statistical analyses included descriptive measures, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests, Pearson\u2019s correlation, and one-way ANOVA, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.05 considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher DLQI scores were significantly associated with greater body-surface-area involvement, facial + body distribution, and bilateral lesions. Emotional distress, clothing limitations, and restricted social and leisure activities were the most affected domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitiligo markedly impairs QoL, particularly when lesions are visible and extensive. Incorporating routine DLQI screening and psychosocial support into dermatologic practice may improve holistic patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.21660","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:41:24Z","timestamp":1788529284000},"page":"e21660","source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial burden and quality of life impairment in adults with vitiligo: a cross-sectional assessment"],"prefix":"10.7717","volume":"14","author":[{"given":"Asma Malawi","family":"Alshahrani","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, College of pharmacy, Shaqra University, Dawadmi, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshimi","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Aseer, Saudi 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