{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:52:45Z","timestamp":1791190365425,"version":"4.1.0"},"reference-count":61,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Cyhalofop-butyl, an aryloxyphenoxypropionate acetyl-CoA carboxylase (ACCase) inhibitor, and quinclorac, a quinolinecarboxylic acid herbicide with auxin-like activity, are commonly used in rice production. This study evaluated the genotoxic potential of the herbicides cyhalofop-butyl and quinclorac in the\n                    <jats:italic>in vivo Drosophila melanogaster<\/jats:italic>\n                    smart assay. Trans-heterozygous larvae obtained from crosses between the multiple wing hairs (\n                    <jats:italic>mwh<\/jats:italic>\n                    ) and\n                    <jats:italic>flare<\/jats:italic>\n                    -3 (\n                    <jats:italic>flr<\/jats:italic>\n                    <jats:sup>3<\/jats:sup>\n                    ) strains were exposed to four concentrations (1, 2, 5, and 10 ppm) of each herbicide. Both herbicides significantly increased clone frequencies compared with the negative control. Cyhalofop-butyl exhibited a concentration-related increase in total spot frequencies, whereas quinclorac consistently elevated clone frequencies across all tested concentrations without a clear dose-dependent pattern. To the best of our knowledge, this is the first report demonstrating the genotoxic potential of cyhalofop-butyl. These findings emphasize the need for careful use of herbicides in rice production and support further investigation of alternative products with lower or no genotoxic potential.\n                  <\/jats:p>","DOI":"10.7717\/peerj.21747","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:12:27Z","timestamp":1791187947000},"page":"e21747","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the genotoxic potential of two rice herbicides, cyhalofop-butyl and quinclorac, in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.7717","volume":"14","author":[{"given":"Serap","family":"Kocao\u011flu-Cenkci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"1","key":"10.7717\/peerj.21747\/ref-1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/etc.5620160106","article-title":"Ecotoxicology of pesticides in the tropical paddy field ecosystem","volume":"16","author":"Abdullah","year":"1997","journal-title":"Environmental Toxicology and Chemistry"},{"issue":"3","key":"10.7717\/peerj.21747\/ref-2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/s0959-437x(00)00190-8","article-title":"Of flies and men-studying human disease in Drosophila","volume":"11","author":"Bernards","year":"2001","journal-title":"Current Opinion in Genetics and 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