{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:13:16Z","timestamp":1772269996107,"version":"3.50.1"},"reference-count":42,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiovascular (CV) disease contributes to nearly half of the mortalities in patients with end-stage renal disease. Patients who received prehemodialysis arteriovenous access (pre-HD AVA) creation had divergent CV outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a population-based cohort study by recruiting incident patients receiving HD from 2001 to 2012 from the Taiwan National Health Insurance Research Database. Patients\u2019 characteristics, comorbidities, and medicines were analyzed. The primary outcome of interest was major adverse cardiovascular events (MACEs), defined as hospitalization due to acute myocardial infarction, stroke, or congestive heart failure (CHF) occurring within the first year of HD. Secondary outcomes included MACE-related mortality and all-cause mortality in the same follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patients in the pre-HD AVA group were younger, had a lower burden of underlying diseases, were more likely to use erythropoiesis-stimulating agents but less likely to use renin\u2013angiotensin\u2013aldosterone system blockers. The patients with pre-HD AVA creation had a marginally lower rate of MACEs but a significant 35% lower rate of CHF hospitalization than those without creation (adjusted hazard ratio (HR) 0.65, 95% confidence interval (CI) [0.48\u20130.88]). In addition, the pre-HD AVA group exhibited an insignificantly lower rate of MACE-related mortality but a significantly 52% lower rate of all-cause mortality than the non-pre-HD AVA group (adjusted HR 0.48, 95% CI [0.39\u20130.59]). Sensitivity analyses obtained consistent results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-HD AVA creation is associated with a lower rate of CHF hospitalization and overall death in the first year of dialysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.6680","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:57:35Z","timestamp":1554263855000},"page":"e6680","source":"Crossref","is-referenced-by-count":0,"title":["Prehemodialysis arteriovenous access creation is associated with better cardiovascular outcomes in patients receiving hemodialysis: a population-based cohort study"],"prefix":"10.7717","volume":"7","author":[{"given":"Cheng-Chieh","family":"Yen","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Ditmansion Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Health Center, Municipal Jingliau Junior High School, Tainan City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peir-Haur","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Ditmansion Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tse-Hsuan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chang Gung Memorial Hospital Linkou, Taoyuan City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Han","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Ditmansion Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung City, Taiwan"},{"name":"Department of Nursing, Min-Hwei College of Health Care Management, Tainan City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"issue":"3","key":"10.7717\/peerj.6680\/ref-1","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.nefro.2015.03.001","article-title":"Cardiac complications of arteriovenous fistulas in patients with end-stage renal disease","volume":"35","author":"Alkhouli","year":"2015","journal-title":"Nefrologia"},{"issue":"12","key":"10.7717\/peerj.6680\/ref-2","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1002\/sim.3150","article-title":"A critical appraisal of propensity-score matching in the medical literature between 1996 and 2003","volume":"27","author":"Austin","year":"2008","journal-title":"Statistics in Medicine"},{"issue":"7","key":"10.7717\/peerj.6680\/ref-3","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1002\/sim.5984","article-title":"The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments","volume":"33","author":"Austin","year":"2014","journal-title":"Statistics in Medicine"},{"issue":"4","key":"10.7717\/peerj.6680\/ref-4","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1177\/0962280215584401","article-title":"The performance of inverse probability of treatment weighting and full matching on the propensity score in the presence of model misspecification when estimating the effect of treatment on survival outcomes","volume":"26","author":"Austin","year":"2017","journal-title":"Statistical Methods in Medical Research"},{"issue":"6","key":"10.7717\/peerj.6680\/ref-5","doi-asserted-by":"publisher","first-page":"e0128715","DOI":"10.1371\/journal.pone.0128715","article-title":"Outcomes of predialysis nephrology care in elderly patients beginning to undergo dialysis","volume":"10","author":"Baek","year":"2015","journal-title":"PLOS ONE"},{"issue":"6","key":"10.7717\/peerj.6680\/ref-6","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.2215\/CJN.01110307","article-title":"Long-term survival of incident hemodialysis patients who are hospitalized for congestive heart failure, pulmonary edema, or fluid overload","volume":"2","author":"Banerjee","year":"2007","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"1","key":"10.7717\/peerj.6680\/ref-7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2215\/CJN.01170905","article-title":"Predictors of early mortality among incident US hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"2","author":"Bradbury","year":"2007","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"3","key":"10.7717\/peerj.6680\/ref-8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.2215\/CJN.03100313","article-title":"A comorbidity index for mortality prediction in Chinese patients with ESRD receiving hemodialysis","volume":"9","author":"Chen","year":"2014","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"1 Suppl 1","key":"10.7717\/peerj.6680\/ref-9","doi-asserted-by":"publisher","first-page":"A6","DOI":"10.1053\/j.ajkd.2009.10.009","article-title":"Excerpts from the US Renal Data System 2009 Annual Data Report","volume":"55","author":"Collins","year":"2010","journal-title":"American Journal of Kidney Diseases"},{"issue":"3","key":"10.7717\/peerj.6680\/ref-10","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3109\/08860228109076018","article-title":"Echocardiographic detection of cardiac effects of arterio-venous dialysis fistula","volume":"5","author":"Dal Canton","year":"1981","journal-title":"Clinical and Experimental Dialysis and Apheresis"},{"key":"10.7717\/peerj.6680\/ref-11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.2147\/ijnrd.s66390","article-title":"The deleterious effects of arteriovenous fistula-creation on the cardiovascular system: a longitudinal magnetic resonance imaging study","volume":"7","author":"Dundon","year":"2014","journal-title":"International Journal of Nephrology and Renovascular Disease"},{"issue":"11","key":"10.7717\/peerj.6680\/ref-12","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.2215\/CJN.00870116","article-title":"Pharmacotherapy of hypertension in chronic dialysis patients","volume":"11","author":"Georgianos","year":"2016","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"6","key":"10.7717\/peerj.6680\/ref-13","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1152\/ajplegacy.1961.200.6.1157","article-title":"Compensations of cardiac output and other circulatory functions in areflex dogs with large A-V fistulas","volume":"200","author":"Guyton","year":"1961","journal-title":"American Journal of Physiology"},{"key":"10.7717\/peerj.6680\/ref-14","volume-title":"2017 Annual report on kidney disease in Taiwan","author":"Hsu","year":"2018"},{"issue":"3","key":"10.7717\/peerj.6680\/ref-15","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1159\/000358843","article-title":"Predialysis care and dialysis outcomes in hemodialysis patients with a functioning fistula","volume":"39","author":"Ishani","year":"2014","journal-title":"American Journal of Nephrology"},{"issue":"5","key":"10.7717\/peerj.6680\/ref-16","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1053\/ajkd.2002.36329","article-title":"Effects of the creation of arteriovenous fistula for hemodialysis on cardiac function and natriuretic peptide levels in CRF","volume":"40","author":"Iwashima","year":"2002","journal-title":"American Journal of Kidney Diseases"},{"issue":"3","key":"10.7717\/peerj.6680\/ref-17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.kint.2018.03.013","article-title":"DOPPS data suggest a possible survival benefit of renin angiotensin-aldosterone system inhibitors and other antihypertensive medications for hemodialysis patients","volume":"94","author":"Karaboyas","year":"2018","journal-title":"Kidney International"},{"issue":"1","key":"10.7717\/peerj.6680\/ref-18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12877-018-0844-x","article-title":"The effects of pre-existing dementia on surgical outcomes in emergent and nonemergent general surgical procedures: assessing differences in surgical risk with dementia","volume":"18","author":"Kassahun","year":"2018","journal-title":"BMC Geriatrics"},{"issue":"4","key":"10.7717\/peerj.6680\/ref-19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1542-4758.2009.00384.x","article-title":"Higher arteriovenous fistulae blood flows are associated with a lower level of dialysis-induced cardiac injury","volume":"13","author":"Korsheed","year":"2009","journal-title":"Hemodialysis International"},{"issue":"10","key":"10.7717\/peerj.6680\/ref-20","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1093\/ndt\/gfq851","article-title":"Effects of arteriovenous fistula formation on arterial stiffness and cardiovascular performance and function","volume":"26","author":"Korsheed","year":"2011","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"5","key":"10.7717\/peerj.6680\/ref-21","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1159\/000446159","article-title":"Reduced cardiovascular mortality associated with early vascular access placement in elderly patients with chronic kidney disease","volume":"43","author":"Lee","year":"2016","journal-title":"American Journal of Nephrology"},{"issue":"6","key":"10.7717\/peerj.6680\/ref-22","doi-asserted-by":"publisher","first-page":"e0198387","DOI":"10.1371\/journal.pone.0198387","article-title":"Effect of national pre-ESRD care program on expenditures and mortality in incident dialysis patients: a population-based study","volume":"13","author":"Lin","year":"2018","journal-title":"PLOS ONE"},{"key":"10.7717\/peerj.6680\/ref-23","first-page":"S42","article-title":"Cardiac hypertrophy and arterial alterations in end-stage renal disease: hemodynamic factors","volume":"41","author":"London","year":"1993","journal-title":"Kidney International Supplements"},{"issue":"5","key":"10.7717\/peerj.6680\/ref-24","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1053\/j.ajkd.2004.01.016","article-title":"Arteriovenous fistula-associated high-output cardiac failure: a review of mechanisms","volume":"43","author":"MacRae","year":"2004","journal-title":"American Journal of Kidney Diseases"},{"issue":"4","key":"10.7717\/peerj.6680\/ref-25","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/ki.2009.207","article-title":"Effects of hemodialysis on cardiac function","volume":"76","author":"McIntyre","year":"2009","journal-title":"Kidney International"},{"issue":"1","key":"10.7717\/peerj.6680\/ref-26","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1159\/000184321","article-title":"Effect of arteriovenous fistula creation and maturation on rest hemodynamics in patients with end-stage renal disease","volume":"46","author":"Munclinger","year":"1987","journal-title":"Nephron"},{"issue":"8","key":"10.7717\/peerj.6680\/ref-27","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1093\/ndt\/gfh840","article-title":"The pathogenesis of pulmonary hypertension in haemodialysis patients via arterio-venous access","volume":"20","author":"Nakhoul","year":"2005","journal-title":"Nephrology Dialysis Transplantation"},{"key":"10.7717\/peerj.6680\/ref-28","first-page":"122","volume-title":"National Health Insurance Annual Report 2014-2015","author":"National Health Insurance Administration","year":"2014"},{"issue":"7","key":"10.7717\/peerj.6680\/ref-29","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1097\/01.ASN.0000131524.52012.F8","article-title":"Late creation of vascular access for hemodialysis and increased risk of sepsis","volume":"15","author":"Oliver","year":"2004","journal-title":"Journal of the American Society of Nephrology"},{"issue":"4","key":"10.7717\/peerj.6680\/ref-30","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1053\/ajkd.2002.35685","article-title":"The contribution of an arteriovenous access for hemodialysis to left ventricular hypertrophy","volume":"40","author":"Ori","year":"2002","journal-title":"American Journal of Kidney Diseases"},{"key":"10.7717\/peerj.6680\/ref-31","first-page":"94","article-title":"Haemodialysis arteriovenous access\u2014a prospective haemodynamic evaluation","volume":"11","author":"Ori","year":"1996","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"3","key":"10.7717\/peerj.6680\/ref-32","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1681\/ASN.2012070643","article-title":"Associations between hemodialysis access type and clinical outcomes: a systematic review","volume":"24","author":"Ravani","year":"2013","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"10.7717\/peerj.6680\/ref-33","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1046\/j.1523-1755.2003.00724.x","article-title":"Creation, cannulation and survival of arteriovenous fistulae: data from the Dialysis Outcomes and Practice Patterns Study","volume":"63","author":"Rayner","year":"2003","journal-title":"Kidney International"},{"issue":"24","key":"10.7717\/peerj.6680\/ref-34","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1093\/eurheartj\/ehx045","article-title":"Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease","volume":"38","author":"Reddy","year":"2017","journal-title":"European Heart Journal"},{"issue":"10041","key":"10.7717\/peerj.6680\/ref-35","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0140-6736(16)30448-2","article-title":"Factors affecting outcomes in patients reaching end-stage kidney disease worldwide: differences in access to renal replacement therapy, modality use, and haemodialysis practices","volume":"388","author":"Robinson","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.7717\/peerj.6680\/ref-36","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1081\/JDI-200037128","article-title":"Hemodynamic effects of arteriovenous fistula in end-stage renal failure","volume":"26","author":"Sandhu","year":"2004","journal-title":"Renal Failure"},{"issue":"4","key":"10.7717\/peerj.6680\/ref-37","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1053\/ajkd.2002.35686","article-title":"The impact of arteriovenous fistula formation on central hemodynamic pressures in chronic renal failure patients: a prospective study","volume":"40","author":"Savage","year":"2002","journal-title":"American Journal of Kidney Diseases"},{"issue":"11","key":"10.7717\/peerj.6680\/ref-38","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1093\/ndt\/gfp276","article-title":"The impact of arteriovenous fistulas on aortic stiffness in patients with chronic kidney disease","volume":"24","author":"Utescu","year":"2009","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"Suppl 1","key":"10.7717\/peerj.6680\/ref-39","doi-asserted-by":"publisher","first-page":"S248","DOI":"10.1053\/j.ajkd.2006.04.040","article-title":"Clinical practice guidelines for vascular access","volume":"48","author":"Vascular Access Work Group","year":"2006","journal-title":"American Journal of Kidney Diseases"},{"issue":"5","key":"10.7717\/peerj.6680\/ref-40","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s40620-014-0056-1","article-title":"Effect of the arteriovenous access for hemodialysis on subendocardial viability ratio, pulse pressure and hospitalizations","volume":"27","author":"Vizinho","year":"2014","journal-title":"Journal of Nephrology"},{"issue":"5","key":"10.7717\/peerj.6680\/ref-41","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1525-139X.2008.00467.x","article-title":"Arteriovenous fistula use is associated with lower cardiovascular mortality compared with catheter use among ESRD patients","volume":"21","author":"Wasse","year":"2008","journal-title":"Seminars in Dialysis"},{"issue":"6","key":"10.7717\/peerj.6680\/ref-42","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.semnephrol.2005.05.002","article-title":"Predictors of cardiovascular death in ESRD","volume":"25","author":"Zoccali","year":"2005","journal-title":"Seminars in Nephrology"}],"container-title":["PeerJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/peerj.com\/articles\/6680.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/6680.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/6680.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/6680.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:57:39Z","timestamp":1554263859000},"score":1,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/6680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":42,"alternative-id":["10.7717\/peerj.6680"],"URL":"https:\/\/doi.org\/10.7717\/peerj.6680","archive":["CLOCKSS","LOCKSS","Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.7287\/peerj.6680v0.1\/reviews\/1","asserted-by":"object"},{"id-type":"doi","id":"10.7287\/peerj.6680v0.1\/reviews\/2","asserted-by":"object"}]},"ISSN":["2167-8359"],"issn-type":[{"value":"2167-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]},"article-number":"e6680"}}