{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:43:53Z","timestamp":1780321433737,"version":"3.54.1"},"reference-count":34,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This investigation was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia","award":["175042 and 175087"],"award-info":[{"award-number":["175042 and 175087"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exfoliative glaucoma (XFG) is typically classified as a high-pressure type of secondary open-angle glaucoma that develops as a consequence of exfoliation syndrome (XFS). Exfoliation syndrome is an age-related, generalized disorder of the extracellular matrix characterized by production and progressive accumulation of a fibrillar exfoliation material (XFM) in intra- and extraocular tissues. Exfoliation material represents complex glycoprotein\/proteoglycan structure composed of a protein core surrounded by glycosaminoglycans such as heparan sulfate (HS) and chondroitin sulfate (CS). The purpose of the present study was to investigate HS and CS concentrations in serum samples of patients with newly diagnosed XFG and compare the obtained values with those pertaining to newly diagnosed primary open-angle glaucoma (POAG), normal controls (NC) and subjects with XFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study involved 165 subjects, including patients with newly diagnosed XFG, patients with newly diagnosed POAG, subjects with XFS and age- and sex-matched NC. The study was conducted at the Glaucoma Department of Clinic for Eye Diseases, Clinical Centre of Serbia, as the referral center for glaucoma in Serbia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age in the XFG, POAG, XFS and NC groups was 73.3 \u00b1 9.0, 66.3 \u00b1 7.8, 75.5 \u00b1 7.0 and 73.5 \u00b1 9.5 years, respectively, XFG vs. POAG,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001. Mean serum HS concentrations in the XFG, POAG, NC and XFS groups were 3,189.0 \u00b1 1,473.8 ng\/mL, 2,091.5 \u00b1 940.9 ng\/mL, 2,543.1 \u00b1 1,397.3 ng\/mL and 2,658.2 \u00b1 1,426.8 ng\/mL respectively, XFG vs. POAG,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001 and XFG vs. NC,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.032. Mean serum CS concentrations in the XFG, POAG, NC and XFS group were 43.9 \u00b1 20.7 ng\/mL, 38.5 \u00b1 22.0 ng\/mL, 35.8 \u00b1 16.4 ng\/mL and 43.3 \u00b1 21.8 ng\/mL, respectively, XFG vs. NC,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings revealed greater HS and CS concentrations in XFG patients and XFS subjects compared to those without XFM. Implications of HS and CS in the pathophysiology of XFS and glaucoma should be studied further. Serum is easily accessible and should thus be explored as rich sources of potential biomarkers. Further research should aim to identify XFG biomarkers that could be utilized in routine blood analysis tests, aiding in timely disease diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.6920","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T04:38:47Z","timestamp":1558586327000},"page":"e6920","source":"Crossref","is-referenced-by-count":7,"title":["Serum heparan sulfate and chondroitin sulfate concentrations in patients with newly diagnosed exfoliative glaucoma"],"prefix":"10.7717","volume":"7","author":[{"given":"Vesna D.","family":"Maric","sequence":"first","affiliation":[{"name":"Clinic for Eye Diseases, Clinical Center of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija M.","family":"Bozic","sequence":"additional","affiliation":[{"name":"Clinic for Eye Diseases, Clinical Center of Serbia, Belgrade, 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