{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:24:57Z","timestamp":1767666297609},"reference-count":26,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"crossref","award":["RSA6080040"],"award-info":[{"award-number":["RSA6080040"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Nasal irrigation is widely used as an adjunctive treatment for nasal diseases. There is little evidence regarding the efficacy of the devices used in this procedure. The objective of this survey was to evaluate the effectiveness of nasal irrigation devices based on the experiences of patients and physicians.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>We conducted a multicentre survey study between November 2017 and October 2018. Physician and patient questionnaires were developed based on the available literature and expert opinion. The physician questionnaire was submitted to the Otolaryngology residents and staff of each centre and their network. The physicians were also asked to distribute the patient questionnaire to their patients.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>Information regarding 331 devices used by the patients was collected. The mean age of the patients was 45.46\u00a0\u00b1\u00a017.19 years (from 5 to 81). Roughly half were male, and half were female (48.6%: 51.4%). Among the high-pressure devices, we found that the high-pressure large-volume nasal irrigation devices yielded significantly higher symptom scores in seven of 12 domains (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Among the large-volume devices, we found that the large-volume high-pressure nasal irrigation devices received significantly higher symptom scores in 4 of 12 domains (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). However, a higher proportion of patients using the large-volume high-pressure devices had retained fluid in the sinuses compared to those using large-volume low-pressure devices (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusions<\/jats:title>\n               <jats:p>This survey supports the regular use of nasal irrigation, particularly with large-volume high-pressure devices, as an effective treatment for nasal disease. It may be effective at clearing nasal secretion, improve nasal congestion, decrease post-nasal drip, improve sinus pain or headache, improve taste and smell, and improve sleep quality. It could be used by patients with good compliance and minimal side effects.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.7000","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T08:16:35Z","timestamp":1558944995000},"page":"e7000","source":"Crossref","is-referenced-by-count":14,"title":["Effectiveness of nasal irrigation devices: a Thai multicentre survey"],"prefix":"10.7717","volume":"7","author":[{"given":"Patorn","family":"Piromchai","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charoiboon","family":"Puvatanond","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virat","family":"Kirtsreesakul","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla,  Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saisawat","family":"Chaiyasate","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanguansak","family":"Thanaviratananich","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"10.7717\/peerj.7000\/ref-1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1164\/ajrccm.160.2.9805081","article-title":"Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans","volume":"160","author":"Baraniuk","year":"1999","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.7717\/peerj.7000\/ref-2","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/00005537-200203000-00029","article-title":"Nasal mucociliary transport: new evidence for a key role of ciliary beat frequency","volume":"112","author":"Boek","year":"2002","journal-title":"Laryngoscope"},{"key":"10.7717\/peerj.7000\/ref-3","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic Rhinitis and its impact on Asthma (ARIA) guidelines\u20142016 revision","volume":"140","author":"Brozek","year":"2017","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.7717\/peerj.7000\/ref-4","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1007\/s00405-013-2398-z","article-title":"Nasal douches for diseases of the nose and the paranasal sinuses\u2014a comparative in vitro investigation","volume":"270","author":"Campos","year":"2013","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"key":"10.7717\/peerj.7000\/ref-5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011995.pub2","article-title":"Saline irrigation for chronic rhinosinusitis","volume":"4","author":"Chong","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.7717\/peerj.7000\/ref-6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4193\/Rhino50E2","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.7717\/peerj.7000\/ref-7","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1378\/chest.106.5.1487","article-title":"Nasal hyperthermia and simple irrigation for perennial rhinitis. Changes in inflammatory mediators","volume":"106","author":"Georgitis","year":"1994","journal-title":"Chest"},{"key":"10.7717\/peerj.7000\/ref-8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012597.pub2","article-title":"Saline irrigation for allergic rhinitis","volume":"6","author":"Head","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.7717\/peerj.7000\/ref-9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.cmet.2015.02.003","article-title":"Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense","volume":"21","author":"Jantsch","year":"2015","journal-title":"Cell Metabolism"},{"key":"10.7717\/peerj.7000\/ref-10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/1945892418773566","article-title":"Hypertonic saline versus isotonic saline nasal irrigation: systematic review and meta-analysis","volume":"32","author":"Kanjanawasee","year":"2018","journal-title":"American Journal of Rhinology & Allergy"},{"issue":"1","key":"10.7717\/peerj.7000\/ref-11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1542\/peds.109.1.165","article-title":"Nasal saline for acute sinusitis","volume":"109","author":"Karadag","year":"2002","journal-title":"Pediatrics"},{"key":"10.7717\/peerj.7000\/ref-12","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1080\/00016480510012381","article-title":"Effect of hypo-, iso- and hypertonic saline irrigation on secretory mucins and morphology of cultured human nasal epithelial cells","volume":"125","author":"Kim","year":"2005","journal-title":"Acta Otolaryngologica"},{"key":"10.7717\/peerj.7000\/ref-13","doi-asserted-by":"publisher","first-page":"CD006821","DOI":"10.1002\/14651858.CD006821.pub3","article-title":"Saline nasal irrigation for acute upper respiratory tract infections","volume":"4","author":"King","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.7717\/peerj.7000\/ref-14","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1378\/chest.124.5.2036","article-title":"A reappraisal of nasal saline solution use in chronic sinusitis","volume":"124","author":"Kurtaran","year":"2003","journal-title":"Chest"},{"key":"10.7717\/peerj.7000\/ref-15","author":"National Statistical Office of Thailand","year":"2019","journal-title":"Outpatient statistic from 2009\u20132017"},{"key":"10.7717\/peerj.7000\/ref-16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2147\/IJGM.S29977","article-title":"Chronic rhinosinusitis and emerging treatment options","volume":"6","author":"Piromchai","year":"2013","journal-title":"International Journal of General Medicine"},{"key":"10.7717\/peerj.7000\/ref-17","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jaci.2005.03.049","article-title":"Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis","volume":"116","author":"Ponikau","year":"2005","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"5","key":"10.7717\/peerj.7000\/ref-18","doi-asserted-by":"publisher","first-page":"E516","DOI":"10.3390\/ijerph14050516","article-title":"Nasal irrigation: an imprecisely defined medical procedure","volume":"14","author":"Principi","year":"2017","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"10.7717\/peerj.7000\/ref-19","doi-asserted-by":"publisher","first-page":"13630","DOI":"10.1038\/s41598-018-31936-y","article-title":"Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels","volume":"8","author":"Ramalingam","year":"2018","journal-title":"Scientific Reports"},{"key":"10.7717\/peerj.7000\/ref-20","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/s41598-018-37703-3","article-title":"A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold","volume":"9","author":"Ramalingam","year":"2019","journal-title":"Scientific Reports"},{"key":"10.7717\/peerj.7000\/ref-21","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599815572097","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngology- Head and Neck Surgery"},{"key":"10.7717\/peerj.7000\/ref-22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/coa.12132","article-title":"A prospective randomised single-blinded clinical trial comparing the efficacy and tolerability of the nasal douching products Sterimar and Sinus Rinse following functional endoscopic sinus surgery","volume":"38","author":"Salib","year":"2013","journal-title":"Clinical Otolaryngology"},{"key":"10.7717\/peerj.7000\/ref-23","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/cea.12953","article-title":"BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007)","volume":"47","author":"Scadding","year":"2017","journal-title":"Clinical and Experimental Allergy"},{"key":"10.7717\/peerj.7000\/ref-24","doi-asserted-by":"publisher","first-page":"CD007909","DOI":"10.1002\/14651858.CD007909.pub4","article-title":"Decongestants, antihistamines and nasal irrigation for acute sinusitis in children","volume":"10","author":"Shaikh","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.7717\/peerj.7000\/ref-25","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/00005537-199704000-00013","article-title":"Mucociliary clearance and buffered hypertonic saline solution","volume":"107","author":"Talbot","year":"1997","journal-title":"Laryngoscope"},{"key":"10.7717\/peerj.7000\/ref-26","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1097\/01.mlg.0000149463.95950.c5","article-title":"A comparative study of three methods of nasal irrigation","volume":"114","author":"Wormald","year":"2004","journal-title":"Laryngoscope"}],"container-title":["PeerJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/peerj.com\/articles\/7000.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/7000.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/7000.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/7000.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T08:16:41Z","timestamp":1558945001000},"score":1,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/7000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,27]]},"references-count":26,"alternative-id":["10.7717\/peerj.7000"],"URL":"https:\/\/doi.org\/10.7717\/peerj.7000","archive":["CLOCKSS","LOCKSS","Portico"],"relation":{},"ISSN":["2167-8359"],"issn-type":[{"value":"2167-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,27]]},"article-number":"e7000"}}