{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:10:42Z","timestamp":1791465042124,"version":"4.3.4"},"reference-count":42,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Vitiligo is a chronic asymptomatic disorder affecting melanocytes from the basal layer of the epidermis which leads to a patchy loss of skin color. Even though it is one of the neglected disease conditions, people suffering from vitiligo are more prone to psychological disorders. As of now, various studies have been done in order to project auto-immune implications as the root cause. To understand the complexity of vitiligo, we propose the Vitiligo Information Resource (VIRdb) that integrates both the drug-target and systems approach to produce a comprehensive repository entirely devoted to vitiligo, along with curated information at both protein level and gene level along with potential therapeutics leads. These 25,041 natural compounds are curated from Natural Product Activity and Species Source Database. VIRdb is an attempt to accelerate the drug discovery process and laboratory trials for vitiligo through the computationally derived potential drugs. It is an exhaustive resource consisting of 129 differentially expressed genes, which are validated through gene ontology and pathway enrichment analysis. We also report 22 genes through enrichment analysis which are involved in the regulation of epithelial cell differentiation. At the protein level, 40 curated protein target molecules along with their natural hits that are derived through virtual screening. We also demonstrate the utility of the VIRdb by exploring the Protein\u2013Protein Interaction Network and Gene\u2013Gene Interaction Network of the target proteins and differentially expressed genes. For maintaining the quality and standard of the data in the VIRdb, the gold standard in bioinformatics toolkits like Cytoscape, Schr\u00f6dinger\u2019s GLIDE, along with the server installation of MATLAB, are used for generating results. VIRdb can be accessed through \u201c<jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.vitiligoinfores.com\/\">http:\/\/www.vitiligoinfores.com\/<\/jats:uri>\u201d.<\/jats:p>","DOI":"10.7717\/peerj.9119","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T10:44:01Z","timestamp":1590057841000},"page":"e9119","source":"Crossref","is-referenced-by-count":6,"title":["VIRdb: a comprehensive database for interactive analysis of genes\/proteins involved in the pathogenesis of vitiligo"],"prefix":"10.7717","volume":"8","author":[{"given":"Priyansh","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alakto","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehak","family":"Talwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7099-5750","authenticated-orcid":true,"given":"Sabyasachi","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Narad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-3675","authenticated-orcid":true,"given":"Abhishek","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"issue":"1","key":"10.7717\/peerj.9119\/ref-1","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1038\/srep04092","article-title":"Importance of collection in gene set enrichment analysis of drug response in cancer cell lines","volume":"4","author":"Bateman","year":"2014","journal-title":"Scientific Reports"},{"issue":"1","key":"10.7717\/peerj.9119\/ref-2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10.7717\/peerj.9119\/ref-3","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3390\/ijms19051509","article-title":"Clinical and molecular aspects of vitiligo treatments","volume":"19","author":"Bishnoi","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.7717\/peerj.9119\/ref-4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12016-017-8622-7","article-title":"Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy","volume":"54","author":"Boniface","year":"2017","journal-title":"Clinical Reviews in Allergy & Immunology"},{"issue":"7","key":"10.7717\/peerj.9119\/ref-5","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.jmb.2019.02.003","article-title":"Relative binding affinity prediction of charge-changing sequence mutations with FEP in protein\u2013protein interfaces","volume":"431","author":"Clark","year":"2019","journal-title":"Journal of Molecular Biology"},{"key":"10.7717\/peerj.9119\/ref-6","first-page":"93","article-title":"The gene expression omnibus database","volume-title":"Statistical Genomics. 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