{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:26:04Z","timestamp":1771561564307,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,25]]},"DOI":"10.7759\/cureus.100073","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T18:34:12Z","timestamp":1766687652000},"source":"Crossref","is-referenced-by-count":1,"title":["Pulmonary Arterial Hypertension: Recognition and Management in Primary and Acute Care Settings"],"prefix":"10.7759","author":[{"given":"Brian J","family":"Ahern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean T","family":"Fulford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl L","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01324-2024","article-title":"Definition, classification and diagnosis of pulmonary hypertension","volume":"64","author":"Kovacs G","year":"2024","unstructured":"Kovacs G, Bartolome S, Denton CP, et al.. Definition, classification and diagnosis of pulmonary hypertension. Eur Respir J. 2024, 64:2401324. 10.1183\/13993003.01324-2024","journal-title":"Eur Respir J"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2000348","article-title":"Pulmonary arterial hypertension","volume":"385","author":"Hassoun PM","year":"2021","unstructured":"Hassoun PM. Pulmonary arterial hypertension. N Engl J Med. 2021, 385:2361-76. 10.1056\/NEJMra2000348","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.4402","article-title":"Diagnosis and treatment of pulmonary arterial hypertension: a review","volume":"327","author":"Ruopp NF","year":"2022","unstructured":"Ruopp NF, Cockrill BA. Diagnosis and treatment of pulmonary arterial hypertension: a review. JAMA. 2022, 327:1379-91. 10.1001\/jama.2022.4402","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.01.046","article-title":"Outcomes of pulmonary arterial hypertension are improved in a specialty\u00a0care center","volume":"158","author":"Pi H","year":"2020","unstructured":"Pi H, Kosanovich CM, Handen A, et al.. Outcomes of pulmonary arterial hypertension are improved in a specialty\u00a0care center. Chest. 2020, 158:330-40. 10.1016\/j.chest.2020.01.046","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06446-y","article-title":"Pulmonary hypertension in connective tissue diseases: epidemiology, pathogenesis, and treatment","volume":"42","author":"Cansu D\u00dc","year":"2023","unstructured":"Cansu D\u00dc, Korkmaz C. Pulmonary hypertension in connective tissue diseases: epidemiology, pathogenesis, and treatment. Clin Rheumatol. 2023, 42:2601-10. 10.1007\/s10067-022-06446-y","journal-title":"Clin Rheumatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"Humbert M","year":"2023","unstructured":"Humbert M, Kovacs G, Hoeper MM, et al.. 2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2023, 61:2200879. 10.1183\/13993003.00879-2022","journal-title":"Eur Respir J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1166","article-title":"Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry","volume":"140","author":"Brown LM","year":"2011","unstructured":"Brown LM, Chen H, Halpern S, et al.. Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry. Chest. 2011, 140:19-26. 10.1378\/chest.10-1166","journal-title":"Chest"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2025.01.028","article-title":"Diagnosis: pulmonary hypertension. Next steps","volume":"138","author":"Gelfman DM","year":"2025","unstructured":"Gelfman DM. Diagnosis: pulmonary hypertension. Next steps. Am J Med. 2025, 138:941-5. 10.1016\/j.amjmed.2025.01.028","journal-title":"Am J Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.02.041","article-title":"Evaluation and management of pulmonary hypertension in the emergency department setting","volume":"38","author":"Simon E","year":"2020","unstructured":"Simon E, Bridwell RE, Montrief T, Koyfman A, Long B. Evaluation and management of pulmonary hypertension in the emergency department setting. Am J Emerg Med. 2020, 38:1237-44. 10.1016\/j.ajem.2020.02.041","journal-title":"Am J Emerg Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029024","article-title":"Revised definition of pulmonary hypertension and approach to management: a clinical primer","volume":"12","author":"Maron BA","year":"2023","unstructured":"Maron BA. Revised definition of pulmonary hypertension and approach to management: a clinical primer. J Am Heart Assoc. 2023, 12:e029024. 10.1161\/JAHA.122.029024","journal-title":"J Am Heart Assoc"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.11.030","article-title":"Therapy for pulmonary arterial hypertension in adults: update of the CHEST Guideline and Expert Panel report","volume":"155","author":"Klinger JR","year":"2019","unstructured":"Klinger JR, Elliott CG, Levine DJ, et al.. Therapy for pulmonary arterial hypertension in adults: update of the CHEST Guideline and Expert Panel report. Chest. 2019, 155:565-86. 10.1016\/j.chest.2018.11.030","journal-title":"Chest"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.2.524","article-title":"Electrocardiography to define clinical status in primary pulmonary hypertension and pulmonary arterial hypertension secondary to collagen vascular disease","volume":"122","author":"Ahearn GS","year":"2002","unstructured":"Ahearn GS, Tapson VF, Rebeiz A, Greenfield JC Jr. Electrocardiography to define clinical status in primary pulmonary hypertension and pulmonary arterial hypertension secondary to collagen vascular disease. Chest. 2002, 122:524-7. 10.1378\/chest.122.2.524","journal-title":"Chest"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA Guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Heidenreich PA","year":"2022","unstructured":"Heidenreich PA, Bozkurt B, Aguilar D, et al.. 2022 AHA\/ACC\/HFSA Guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022, 79:e263-421. 10.1016\/j.jacc.2021.12.012","journal-title":"J Am Coll Cardiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-1155","article-title":"Correlation of right ventricular wall stress with plasma b-type natriuretic peptide levels in patients with pulmonary hypertension","volume":"83","author":"Uchiyama N","year":"2019","unstructured":"Uchiyama N, Yuasa T, Miyata M, et al.. Correlation of right ventricular wall stress with plasma b-type natriuretic peptide levels in patients with pulmonary hypertension. Circ J. 2019, 83:1278-85. 10.1253\/circj.CJ-18-1155","journal-title":"Circ J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202302-0327SO","article-title":"Pulmonary hypertension: a contemporary review","volume":"208","author":"Johnson S","year":"2023","unstructured":"Johnson S, Sommer N, Cox-Flaherty K, Weissmann N, Ventetuolo CE, Maron BA. Pulmonary hypertension: a contemporary review. Am J Respir Crit Care Med. 2023, 208:528-48. 10.1164\/rccm.202302-0327SO","journal-title":"Am J Respir Crit Care Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0092-2017","article-title":"Acute decompensated pulmonary hypertension","volume":"26","author":"Savale L","year":"2017","unstructured":"Savale L, Weatherald J, Ja\u00efs X, et al.. Acute decompensated pulmonary hypertension. Eur Respir Rev. 2017, 26:170092. 10.1183\/16000617.0092-2017","journal-title":"Eur Respir Rev"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2174\/0118743064359315250210080743","article-title":"Revisiting acute decompensated right ventricle failure in pulmonary arterial hypertension","volume":"19","author":"Masih R","year":"2025","unstructured":"Masih R, Paudyal V, Basnet YM, Sunesara S, Sharma M, Surani S. Revisiting acute decompensated right ventricle failure in pulmonary arterial hypertension. Open Respir Med J. 2025, 19:e18743064359315. 10.2174\/0118743064359315250210080743","journal-title":"Open Respir Med J"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2024.11.009","article-title":"Acute decompensated pulmonary hypertension outcomes in pulmonary arterial hypertension patients: systematic review and meta-analysis of proportions","volume":"70","author":"Garcia MV","year":"2025","unstructured":"Garcia MV, Nanah A, Caruso P. Acute decompensated pulmonary hypertension outcomes in pulmonary arterial hypertension patients: systematic review and meta-analysis of proportions. Heart Lung. 2025, 70:57-64. 10.1016\/j.hrtlng.2024.11.009","journal-title":"Heart Lung"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-021-10168-9","article-title":"Advanced airway management and respiratory care in decompensated pulmonary hypertension","volume":"27","author":"Vahdatpour CA","year":"2022","unstructured":"Vahdatpour CA, Ryan JJ, Zimmerman JM, MacCormick SJ, Palevsky HI, Alnuaimat H, Ataya A. Advanced airway management and respiratory care in decompensated pulmonary hypertension. Heart Fail Rev. 2022, 27:1807-17. 10.1007\/s10741-021-10168-9","journal-title":"Heart Fail Rev"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.07.525","article-title":"Pulmonary hypertension and right ventricular failure in emergency medicine","volume":"66","author":"Wilcox SR","year":"2015","unstructured":"Wilcox SR, Kabrhel C, Channick RN. Pulmonary hypertension and right ventricular failure in emergency medicine. Ann Emerg Med. 2015, 66:619-28. 10.1016\/j.annemergmed.2015.07.525","journal-title":"Ann Emerg Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.1.191","article-title":"Systemic and pulmonary hypertension after abrupt cessation of prostacyclin: role of thromboxane A2","volume":"80","author":"Cuiper LL","year":"1996","unstructured":"Cuiper LL, Price PV, Christman BW. Systemic and pulmonary hypertension after abrupt cessation of prostacyclin: role of thromboxane A2. J Appl Physiol. 1996, 80:191-7. 10.1152\/jappl.1996.80.1.191","journal-title":"J Appl Physiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.540","article-title":"Management of pulmonary arterial\u00a0hypertension","volume":"65","author":"McLaughlin VV","year":"2015","unstructured":"McLaughlin VV, Shah SJ, Souza R, Humbert M. Management of pulmonary arterial\u00a0hypertension. J Am Coll Cardiol. 2015, 65:1976-97. 10.1016\/j.jacc.2015.03.540","journal-title":"J Am Coll Cardiol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.06.042","article-title":"Drug-drug interactions in the management of patients with pulmonary arterial hypertension","volume":"162","author":"Wu S","year":"2022","unstructured":"Wu S, Hoang HB, Yang JZ, et al.. Drug-drug interactions in the management of patients with pulmonary arterial hypertension. Chest. 2022, 162:1360-72. 10.1016\/j.chest.2022.06.042","journal-title":"Chest"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4041-5","article-title":"Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance","volume":"42","author":"Mebazaa A","year":"2016","unstructured":"Mebazaa A, Tolppanen H, Mueller C, et al.. Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance. Intensive Care Med. 2016, 42:147-63. 10.1007\/s00134-015-4041-5","journal-title":"Intensive Care Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.05.030","article-title":"Right heart failure: a narrative review for emergency clinicians","volume":"58","author":"Kostura M","year":"2022","unstructured":"Kostura M, Smalley C, Koyfman A, Long B. Right heart failure: a narrative review for emergency clinicians. Am J Emerg Med. 2022, 58:106-13. 10.1016\/j.ajem.2022.05.030","journal-title":"Am J Emerg Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13071862","article-title":"Effect of nasal high flow (NHF) on right heart function in stable patients with pulmonary hypertension of different WHO classes","volume":"13","author":"Br\u00e4unlich J","year":"2024","unstructured":"Br\u00e4unlich J, Seyfarth HJ, Wirtz H. Effect of nasal high flow (NHF) on right heart function in stable patients with pulmonary hypertension of different WHO classes. J Clin Med. 2024, 13:1862. 10.3390\/jcm13071862","journal-title":"J Clin Med"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175472","article-title":"Effects of high-flow nasal cannula on right heart dysfunction in patients with acute-on-chronic respiratory failure and pulmonary hypertension","volume":"12","author":"Pelaia C","year":"2023","unstructured":"Pelaia C, Armentaro G, Lupia C, et al.. Effects of high-flow nasal cannula on right heart dysfunction in patients with acute-on-chronic respiratory failure and pulmonary hypertension. J Clin Med. 2023, 12:5472. 10.3390\/jcm12175472","journal-title":"J Clin Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23264","article-title":"Role of high-flow nasal oxygen therapy in cases with pulmonary hypertension in an intensive care unit setting","volume":"23","author":"Gupta B","year":"2019","unstructured":"Gupta B, Kerai S, Kakkar K, Gupta L. Role of high-flow nasal oxygen therapy in cases with pulmonary hypertension in an intensive care unit setting. Indian J Crit Care Med. 2019, 23:458-61. 10.5005\/jp-journals-10071-23264","journal-title":"Indian J Crit Care Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2014.03.003","article-title":"Management of right heart failure in the critically ill","volume":"30","author":"King C","year":"2014","unstructured":"King C, May CW, Williams J, Shlobin OA. Management of right heart failure in the critically ill. Crit Care Clin. 2014, 30:475-98. 10.1016\/j.ccc.2014.03.003","journal-title":"Crit Care Clin"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001136","article-title":"Evaluation and management of pulmonary hypertension in noncardiac surgery: a scientific statement from the American Heart Association","volume":"147","author":"Rajagopal S","year":"2023","unstructured":"Rajagopal S, Ruetzler K, Ghadimi K, et al.. Evaluation and management of pulmonary hypertension in noncardiac surgery: a scientific statement from the American Heart Association. Circulation. 2023, 147:1317-43. 10.1161\/CIR.0000000000001136","journal-title":"Circulation"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2207410","article-title":"Right ventricular failure","volume":"388","author":"Houston BA","year":"2023","unstructured":"Houston BA, Brittain EL, Tedford RJ. Right ventricular failure. N Engl J Med. 2023, 388:1111-25. 10.1056\/NEJMra2207410","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-015-0052-1","article-title":"Experts' recommendations for the management of adult patients with cardiogenic shock","volume":"5","author":"Levy B","year":"2015","unstructured":"Levy B, Bastien O, Karim B, et al.. Experts' recommendations for the management of adult patients with cardiogenic shock. Ann Intensive Care. 2015, 5:17. 10.1186\/s13613-015-0052-1","journal-title":"Ann Intensive Care"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0662CI","article-title":"Intensive care unit management of patients with severe pulmonary hypertension and right heart failure","volume":"184","author":"Hoeper MM","year":"2011","unstructured":"Hoeper MM, Granton J. Intensive care unit management of patients with severe pulmonary hypertension and right heart failure. Am J Respir Crit Care Med. 2011, 184:1114-24. 10.1164\/rccm.201104-0662CI","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/441966-pulmonary-arterial-hypertension-recognition-and-management-in-primary-and-acute-care-settings","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T18:34:13Z","timestamp":1766687653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/441966-pulmonary-arterial-hypertension-recognition-and-management-in-primary-and-acute-care-settings"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,25]]},"references-count":33,"URL":"https:\/\/doi.org\/10.7759\/cureus.100073","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,25]]}}}