{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:45:58Z","timestamp":1766735158668,"version":"3.48.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,25]]},"DOI":"10.7759\/cureus.100100","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:44:25Z","timestamp":1766735065000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Cariogenic Potential of Two Sweeteners, Stevia and Aspartame, Based on Bacterial Inhibition and pH Reduction"],"prefix":"10.7759","author":[{"given":"Reshmi","family":"J","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaniya","family":"Sain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.44.2.331-384.1980","article-title":"Biology, immunology, and cariogenicity of Streptococcus mutans","volume":"44","author":"Hamada S","year":"1980","unstructured":"Hamada S, Slade HD. Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev. 1980, 44:331-84. 10.1128\/mr.44.2.331-384.1980","journal-title":"Microbiol Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01631-8","article-title":"Herbal remedies for oral and dental health: a comprehensive review of their multifaceted mechanisms including antimicrobial, anti-inflammatory, and antioxidant pathways","volume":"33","author":"Anwar MA","year":"2025","unstructured":"Anwar MA, Sayed GA, Hal DM, et al.. Herbal remedies for oral and dental health: a comprehensive review of their multifaceted mechanisms including antimicrobial, anti-inflammatory, and antioxidant pathways. Inflammopharmacology. 2025, 33:1085-160. 10.1007\/s10787-024-01631-8","journal-title":"Inflammopharmacology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0307","article-title":"The science and practice of caries prevention","volume":"131","author":"Featherstone JD","year":"2000","unstructured":"Featherstone JD. The science and practice of caries prevention. J Am Dent Assoc. 2000, 131:887-99. 10.14219\/jada.archive.2000.0307","journal-title":"J Am Dent Assoc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.6998.141","article-title":"Children's dental health and medicines that contain sugar","volume":"311","author":"Mackie IC","year":"1995","unstructured":"Mackie IC. Children's dental health and medicines that contain sugar. BMJ. 1995, 311:141-2. 10.1136\/bmj.311.6998.141","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1093\/her\/8.4.519","article-title":"A qualitative investigation into general practitioners' views on prescribing sugar-free medicines for children prior to a dental health education campaign","volume":"8","author":"Bentley EM","year":"1993","unstructured":"Bentley EM, Mackie IC. A qualitative investigation into general practitioners' views on prescribing sugar-free medicines for children prior to a dental health education campaign. Health Educ Res. 1993, 8:519-24.","journal-title":"Health Educ Res"},{"key":"ref6","unstructured":"Aspartame hazard and risk assessment results released. (2023). Accessed. October 31, 2025: https:\/\/www.who.int\/news\/item\/14-07-2023-aspartame-hazard-and-risk-assessment-results-released?."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2016.0171","article-title":"Stevia rebaudiana Bertoni: a natural alternative for treating diseases associated with metabolic syndrome","volume":"20","author":"Carrera-Lanestosa A","year":"2017","unstructured":"Carrera-Lanestosa A, Moguel-Ord\u00f3\u00f1ez Y, Segura-Campos M. Stevia rebaudiana Bertoni: a natural alternative for treating diseases associated with metabolic syndrome. J Med Food. 2017, 20:933-43. 10.1089\/jmf.2016.0171","journal-title":"J Med Food"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/519421","article-title":"Role of sugar and sugar substitutes in dental caries: a review","volume":"2013","author":"Gupta P","year":"2013","unstructured":"Gupta P, Gupta N, Pawar AP, Birajdar SS, Natt AS, Singh HP. Role of sugar and sugar substitutes in dental caries: a review. ISRN Dent. 2013, 2013:519421. 10.1155\/2013\/519421","journal-title":"ISRN Dent"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.51299","article-title":"The impact of artificial sweeteners on human health and cancer association: a comprehensive clinical review","volume":"15","author":"Ghusn W","year":"2023","unstructured":"Ghusn W, Naik R, Yibirin M. The impact of artificial sweeteners on human health and cancer association: a comprehensive clinical review. Cureus. 2023, 15:e51299. 10.7759\/cureus.51299","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2016.11.004","article-title":"Consumption of low-calorie sweeteners among children and adults in the United States","volume":"117","author":"Sylvetsky AC","year":"2017","unstructured":"Sylvetsky AC, Jin Y, Clark EJ, Welsh JA, Rother KI, Talegawkar SA. Consumption of low-calorie sweeteners among children and adults in the United States. J Acad Nutr Diet. 2017, 117:441-8.e2. 10.1016\/j.jand.2016.11.004","journal-title":"J Acad Nutr Diet"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320510","article-title":"Artificial sweeteners and absence of bladder cancer risk in Copenhagen","volume":"32","author":"M\u00f8ller-Jensen O","year":"1983","unstructured":"M\u00f8ller-Jensen O, Knudsen JB, S\u00f8rensen BL, Clemmesen J. Artificial sweeteners and absence of bladder cancer risk in Copenhagen. Int J Cancer. 1983, 32:577-82. 10.1002\/ijc.2910320510","journal-title":"Int J Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2395","article-title":"The relationship between the use of artificial sweeteners and cancer: a meta-analysis of case-control studies","volume":"9","author":"Liu L","year":"2021","unstructured":"Liu L, Zhang P, Wang Y, Cui W, Li D. The relationship between the use of artificial sweeteners and cancer: a meta-analysis of case-control studies. Food Sci Nutr. 2021, 9:4589-97. 10.1002\/fsn3.2395","journal-title":"Food Sci Nutr"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91428-3","article-title":"Artificial sweeteners and human bladder cancer","volume":"310","author":"Howe GR","year":"1977","unstructured":"Howe GR, Burch JD, Miller AB, et al.. Artificial sweeteners and human bladder cancer. Lancet. 1977, 310:578-81. 10.1016\/S0140-6736(77)91428-3","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(85)90147-4","article-title":"A review of epidemiological studies on artificial sweeteners and bladder cancer","volume":"23","author":"Morgan RW","year":"1985","unstructured":"Morgan RW, Wong O. A review of epidemiological studies on artificial sweeteners and bladder cancer. Food Chem Toxicol. 1985, 23:529-33. 10.1016\/0278-6915(85)90147-4","journal-title":"Food Chem Toxicol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.59","article-title":"Artificial sweeteners and bladder cancer in Manchester, U.K., and Nagoya, Japan","volume":"45","author":"Morrison AS","year":"1982","unstructured":"Morrison AS, Verhoek WG, Leck I, Aoki K, Ohno Y, Obata K. Artificial sweeteners and bladder cancer in Manchester, U.K., and Nagoya, Japan. Br J Cancer. 1982, 45:332-6. 10.1038\/bjc.1982.59","journal-title":"Br J Cancer"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2022.11.016","article-title":"Association of artificially sweetened beverage consumption and urinary tract cancers in the women's health initiative observational study","volume":"47","author":"Ringel NE","year":"2023","unstructured":"Ringel NE, Hovey KM, Andrews CA, et al.. Association of artificially sweetened beverage consumption and urinary tract cancers in the women's health initiative observational study. Eur Urol Open Sci. 2023, 47:80-6. 10.1016\/j.euros.2022.11.016","journal-title":"Eur Urol Open Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183742","article-title":"Can artificial sweeteners increase the risk of cancer incidence and mortality: evidence from prospective studies","volume":"14","author":"Yan S","year":"2022","unstructured":"Yan S, Yan F, Liu L, Li B, Liu S, Cui W. Can artificial sweeteners increase the risk of cancer incidence and mortality: evidence from prospective studies. Nutrients. 2022, 14:3742. 10.3390\/nu14183742","journal-title":"Nutrients"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20896","article-title":"Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice","volume":"53","author":"Soffritti M","year":"2010","unstructured":"Soffritti M, Belpoggi F, Manservigi M, Tibaldi E, Lauriola M, Falcioni L, Bua L. Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice. Am J Ind Med. 2010, 53:1197-206. 10.1002\/ajim.20896","journal-title":"Am J Ind Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.11594\/nstp.2022.2514","article-title":"Cariogenic antibacterial potential of Stevia rebaudiana Bertoni leaves extract against Lactobacillus acidophilus","author":"Deviyanti S","year":"2022","unstructured":"Deviyanti S. Cariogenic antibacterial potential of Stevia rebaudiana Bertoni leaves extract against Lactobacillus acidophilus. Nusantara Science and Technology Proceedings. 2022. 96-103. 10.11594\/nstp.2022.2514"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.17126\/joralres.2013.034","article-title":"Anticariogenic properties and effects on periodontal structures of Stevia rebaudiana Bertoni. Narrative review","volume":"2","author":"Contreras M","year":"2013","unstructured":"Contreras M. Anticariogenic properties and effects on periodontal structures of Stevia rebaudiana Bertoni. Narrative review. J Oral Res. 2013, 2:158-66. 10.17126\/joralres.2013.034","journal-title":"J Oral Res"},{"key":"ref21","article-title":"Nutritional value, cytotoxic and antimicrobial activities of Stevia rebaudiana leaf extracts","volume":"11","author":"Ibrahem ES","year":"2020","unstructured":"Ibrahem ES, Ragheb EM, Yousef FM, Abdel-Aziz MF, Alghamdi BA. Nutritional value, cytotoxic and antimicrobial activities of Stevia rebaudiana leaf extracts.  J Biochem Tech. 2020, 11:108-15.","journal-title":"J Biochem Tech"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S2222-1808(14)60572-7","article-title":"Phytochemical screening and comparative antimicrobial potential of different extracts of Stevia rebaudiana Bertoni leaves","volume":"4","author":"Siddique AB","year":"2014","unstructured":"Siddique AB, Rahman\u202fSM, Hossain\u202fMA, Hossain\u202fMA, Rashid\u202fMA. Phytochemical screening and comparative antimicrobial potential of different extracts of Stevia rebaudiana Bertoni leaves. Asian Pac J Trop Dis. 2014, 4:275-280. 10.1016\/S2222-1808(14)60572-7","journal-title":"Asian Pac J Trop Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28227572","article-title":"Stevia polyphenols, their antimicrobial and anti-inflammatory properties, and inhibitory effect on digestive enzymes","volume":"28","author":"Myint KZ","year":"2023","unstructured":"Myint KZ, Zhou Z, Shi Q, Chen J, Dong X, Xia Y. Stevia polyphenols, their antimicrobial and anti-inflammatory properties, and inhibitory effect on digestive enzymes. Molecules. 2023, 28:7572. 10.3390\/molecules28227572","journal-title":"Molecules"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041362","article-title":"Anti-cancer properties of Stevia rebaudiana; more than a sweetener","volume":"27","author":"Iatridis N","year":"2022","unstructured":"Iatridis N, Kougioumtzi A, Vlataki K, Papadaki S, Magklara A. Anti-cancer properties of Stevia rebaudiana; more than a sweetener. Molecules. 2022, 27:1362. 10.3390\/molecules27041362","journal-title":"Molecules"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031258","article-title":"Steviol glycosides from stevia rebaudiana: an updated overview of their sweetening activity, pharmacological properties, and safety aspects","volume":"28","author":"Orellana-Paucar AM","year":"2023","unstructured":"Orellana-Paucar AM. Steviol glycosides from stevia rebaudiana: an updated overview of their sweetening activity, pharmacological properties, and safety aspects. Molecules. 2023, 28:1258. 10.3390\/molecules28031258","journal-title":"Molecules"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/403408-comparison-of-the-cariogenic-potential-of-two-sweeteners-stevia-and-aspartame-based-on-bacterial-inhibition-and-ph-reduction","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:44:27Z","timestamp":1766735067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/403408-comparison-of-the-cariogenic-potential-of-two-sweeteners-stevia-and-aspartame-based-on-bacterial-inhibition-and-ph-reduction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,25]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.100100","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,25]]}}}