{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:52:08Z","timestamp":1767966728515,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,25]]},"DOI":"10.7759\/cureus.10029","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:35:00Z","timestamp":1598402100000},"source":"Crossref","is-referenced-by-count":4,"title":["The Current State of Clinical Trials Studying Hydrocephalus: An Analysis of ClinicalTrials.gov"],"prefix":"10.7759","author":[{"given":"Mickey E","family":"Abraham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Povolotskiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian L","family":"Gendreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios","family":"Mammis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s101430050035","article-title":"The scientific history of hydrocephalus and its treatment","volume":"22","author":"Aschoff A","year":"1999","unstructured":"Aschoff A, Kremer P, Hashemi B, Kunze S. The scientific history of hydrocephalus and its treatment. Neurosurg Rev. 1999, 22:67-93. 10.1007\/s101430050035","journal-title":"Neurosurg Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17439","article-title":"Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis","volume":"130","author":"Dewan MC","year":"2018","unstructured":"Dewan MC, Rattani A, Mekary R, et al.. Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis. J Neurosurg. 2018, 130:1-15. 10.3171\/2017.10.JNS17439","journal-title":"J Neurosurg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3171\/2018.6.PEDS17654","article-title":"The cost of hydrocephalus: a cost-effectiveness model for evaluating surgical techniques","volume":"23","author":"Lim J","year":"2018","unstructured":"Lim J, Tang AR, Liles C, et al.. The cost of hydrocephalus: a cost-effectiveness model for evaluating surgical techniques. J Neurosurg Pediatr. 2018, 23:109-118. 10.3171\/2018.6.PEDS17654","journal-title":"J Neurosurg Pediatr"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171\/JNS-07\/07\/0021","article-title":"Influence of shunt surgery on healthcare expenditures of elderly fee-for-service Medicare beneficiaries with hydrocephalus","volume":"107","author":"Williams MA","year":"2007","unstructured":"Williams MA, Sharkey P, van Doren D, Thomas G, Rigamonti D. Influence of shunt surgery on healthcare expenditures of elderly fee-for-service Medicare beneficiaries with hydrocephalus. J Neurosurg. 2007, 107:21-28. 10.3171\/JNS-07\/07\/0021","journal-title":"J Neurosurg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2224-4336.2014.07.02","article-title":"New concepts in the pathogenesis of hydrocephalus","volume":"3","author":"Krishnamurthy S","year":"2014","unstructured":"Krishnamurthy S, Li J. New concepts in the pathogenesis of hydrocephalus. Transl Pediatr. 2014, 3:185-194. 10.3978\/j.issn.2224-4336.2014.07.02","journal-title":"Transl Pediatr"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2016.02.007","article-title":"Imaging of communicating hydrocephalus","volume":"37","author":"Agarwal A","year":"2016","unstructured":"Agarwal A, Bathla G, Kanekar S. Imaging of communicating hydrocephalus. Semin Ultrasound CT MRI. 2016, 37:100-108. 10.1053\/j.sult.2016.02.007","journal-title":"Semin Ultrasound CT MRI"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-5-2","article-title":"The definition and classification of hydrocephalus: a personal recommendation to stimulate debate","volume":"5","author":"Rekate HL","year":"2008","unstructured":"Rekate HL. The definition and classification of hydrocephalus: a personal recommendation to stimulate debate. Cerebrospinal Fluid Res. 2008, 5:2. 10.1186\/1743-8454-5-2","journal-title":"Cerebrospinal Fluid Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS132352","article-title":"An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium \"Opportunities for Hydrocephalus Research: Pathways to Better Outcomes\"","volume":"123","author":"McAllister JP","year":"2015","unstructured":"McAllister JP, Williams MA, Walker ML, et al.. An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium \"Opportunities for Hydrocephalus Research: Pathways to Better Outcomes\". J Neurosurg. 2015, 123:1427-1438. 10.3171\/2014.12.JNS132352","journal-title":"J Neurosurg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3171\/PED-07\/11\/345","article-title":"Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop","volume":"107","author":"Williams MA","year":"2007","unstructured":"Williams MA, McAllister JP, Walker ML, et al.. Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop. J Neurosurg. 2007, 107:345-357. 10.3171\/PED-07\/11\/345","journal-title":"J Neurosurg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12335","article-title":"A review of clinical outcomes for gait and other variables in the surgical treatment of idiopathic normal pressure hydrocephalus","volume":"3","author":"Shaw R","year":"2016","unstructured":"Shaw R, Mahant N, Jacobson E, Owler B. A review of clinical outcomes for gait and other variables in the surgical treatment of idiopathic normal pressure hydrocephalus. Mov Disord Clin Pract. 2016, 3:331-341. 10.1002\/mdc3.12335","journal-title":"Mov Disord Clin Pract"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2011.09.2475","article-title":"Key concepts of clinical trials: a narrative review","volume":"123","author":"Umscheid CA","year":"2011","unstructured":"Umscheid CA, Margolis DJ, Grossman CE. Key concepts of clinical trials: a narrative review. Postgrad Med. 2011, 123:194-204. 10.3810\/pgm.2011.09.2475","journal-title":"Postgrad Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2016.1245848","article-title":"Endoscopic third ventriculostomy: a historical review","volume":"31","author":"Demerdash A","year":"2017","unstructured":"Demerdash A, Rocque BG, Johnston J, et al.. Endoscopic third ventriculostomy: a historical review. Br J Neurosurg. 2017, 31:28-32. 10.1080\/02688697.2016.1245848","journal-title":"Br J Neurosurg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3171\/2012.6.FOCUS12136","article-title":"A lesson in history: the evolution of endoscopic third ventriculostomy","volume":"33","author":"Schmitt PJ","year":"2012","unstructured":"Schmitt PJ, Jane JA, Jr. A lesson in history: the evolution of endoscopic third ventriculostomy. Neurosurg Focus. 2012, 33:11. 10.3171\/2012.6.FOCUS12136","journal-title":"Neurosurg Focus"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2017.0202.013","article-title":"Endoscopic third ventriculostomy: success and failure","volume":"60","author":"Deopujari CE","year":"2017","unstructured":"Deopujari CE, Karmarkar VS, Shaikh ST. Endoscopic third ventriculostomy: success and failure. J Korean Neurosurg Soc. 2017, 60:306-314. 10.3340\/jkns.2017.0202.013","journal-title":"J Korean Neurosurg Soc"},{"key":"ref15","article-title":"Ventriculoperitoneal Shunt","author":"Fowler JB","year":"2019","unstructured":"Fowler JB, De Jesus O, Mesfin FB. Ventriculoperitoneal Shunt. StatPearls, Treasure Island; 2019."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.98222","article-title":"Endoscopic third ventriculostomy","volume":"3","author":"Yadav YR","year":"2012","unstructured":"Yadav YR, Parihar V, Pande S, Namdev H, Agarwal M. Endoscopic third ventriculostomy. J Neurosci Rural Pract. 2012, 3:163-173. 10.4103\/0976-3147.98222","journal-title":"J Neurosci Rural Pract"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.11477\/mf.1416100234","article-title":"[Idiopathic normal pressure hydrocephalus--overviews and pathogenesis]","volume":"60","author":"Ishikawa M","year":"2008","unstructured":"Ishikawa M. [Idiopathic normal pressure hydrocephalus--overviews and pathogenesis]. Brain Nerve. 2008, 60:211-217. 10.11477\/mf.1416100234","journal-title":"Brain Nerve"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000305","article-title":"Diagnosis and treatment of idiopathic normal pressure hydrocephalus","volume":"22","author":"Williams MA","year":"2016","unstructured":"Williams MA, Malm J. Diagnosis and treatment of idiopathic normal pressure hydrocephalus. Continuum. 2016, 22:579-599. 10.1212\/CON.0000000000000305","journal-title":"Continuum"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2011.03.009","article-title":"Prevalence of congenital hydrocephalus in California, 1991-2000","volume":"45","author":"Jeng S","year":"2011","unstructured":"Jeng S, Gupta N, Wrensch M, Zhao S, Wu YW. Prevalence of congenital hydrocephalus in California, 1991-2000. Pediatr Neurol. 2011, 45:67-71. 10.1016\/j.pediatrneurol.2011.03.009","journal-title":"Pediatr Neurol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3171\/PED\/2008\/1\/2\/131","article-title":"Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths","volume":"1","author":"Simon TD","year":"2008","unstructured":"Simon TD, Riva-Cambrin J, Srivastava R, Bratton SL, Michael Dean J, Kestle JR, Hydrocephalus Clinical Research Network. Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths. J Neurosurg Pediatr. 2008, 1:131-137. 10.3171\/PED\/2008\/1\/2\/131","journal-title":"J Neurosurg Pediatr"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.095117","article-title":"Idiopathic normal-pressure hydrocephalus: clinical comorbidity correlated with cerebral biopsy findings and outcome of cerebrospinal fluid shunting","volume":"78","author":"Bech-Azeddine R","year":"2007","unstructured":"Bech-Azeddine R, Hogh P, Juhler M, Gjerris F, Waldemar G. Idiopathic normal-pressure hydrocephalus: clinical comorbidity correlated with cerebral biopsy findings and outcome of cerebrospinal fluid shunting. J Neurol Neurosurg Psychiatry. 2007, 78:157-161. 10.1136\/jnnp.2006.095117","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588473","article-title":"MR phase imaging and cerebrospinal fluid flow in the head and spine","volume":"32","author":"Levy LM","year":"1990","unstructured":"Levy LM, Di Chiro G. MR phase imaging and cerebrospinal fluid flow in the head and spine. Neuroradiology. 1990, 32:399-406. 10.1007\/BF00588473","journal-title":"Neuroradiology"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-11-22","article-title":"A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus","volume":"11","author":"Behrens A","year":"2014","unstructured":"Behrens A, Eklund A, Elgh E, Smith C, Williams MA, Malm J. A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014, 11:22. 10.1186\/2045-8118-11-22","journal-title":"Fluids Barriers CNS"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3095-1","article-title":"International infant hydrocephalus study: initial results of a prospective, multicenter comparison of endoscopic third ventriculostomy (ETV) and shunt for infant hydrocephalus","volume":"32","author":"Kulkarni AV","year":"2016","unstructured":"Kulkarni AV, Sgouros S, Constantini S, Investigators I. International infant hydrocephalus study: initial results of a prospective, multicenter comparison of endoscopic third ventriculostomy (ETV) and shunt for infant hydrocephalus. Childs Nerv Syst. 2016, 32:1039-1048. 10.1007\/s00381-016-3095-1","journal-title":"Childs Nerv Syst"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7554","article-title":"Neurodevelopmental outcome of fetuses referred for ventriculomegaly","volume":"35","author":"Beeghly M","year":"2010","unstructured":"Beeghly M, Ware J, Soul J, et al.. Neurodevelopmental outcome of fetuses referred for ventriculomegaly. Ultrasound Obstet Gynecol. 2010, 35:405-416. 10.1002\/uog.7554","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3171\/2013.9.PEDS1346","article-title":"No significant improvement in the rate of accurate ventricular catheter location using ultrasound-guided CSF shunt insertion: a prospective, controlled study by the Hydrocephalus Clinical Research Network","volume":"12","author":"Whitehead WE","year":"2013","unstructured":"Whitehead WE, Riva-Cambrin J, Wellons JC, et al.. No significant improvement in the rate of accurate ventricular catheter location using ultrasound-guided CSF shunt insertion: a prospective, controlled study by the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr. 2013, 12:565-574. 10.3171\/2013.9.PEDS1346","journal-title":"J Neurosurg Pediatr"},{"key":"ref27","unstructured":"Keyhole surgery for the positioning of the distal catheter in ventricular peritoneal shunt placement. (2020). Accessed. August 25, 2020: https:\/\/ClinicalTrials.gov\/show\/NCT01739179."},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1012065","article-title":"The ClinicalTrials.gov results database: update and key issues","volume":"364","author":"Zarin DA","year":"2011","unstructured":"Zarin DA, Tse T, Williams RJ, Califf RM, Ide NC. The ClinicalTrials.gov results database: update and key issues. N Engl J Med. 2011, 364:852-860. 10.1056\/NEJMsa1012065","journal-title":"N Engl J Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/38615-the-current-state-of-clinical-trials-studying-hydrocephalus-an-analysis-of-clinicaltrialsgov","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:21:25Z","timestamp":1707506485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/38615-the-current-state-of-clinical-trials-studying-hydrocephalus-an-analysis-of-clinicaltrialsgov"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.10029","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8,25]]}}}