{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T16:47:38Z","timestamp":1767458858774,"version":"3.48.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,3]]},"DOI":"10.7759\/cureus.100695","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T16:47:13Z","timestamp":1767458833000},"source":"Crossref","is-referenced-by-count":0,"title":["Extranodal Natural Killer\/T-cell Lymphoma With Skin Involvement: A Case Report"],"prefix":"10.7759","author":[{"given":"Evelyn Itzamara","family":"Figueroa Saavedra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Fernanda","family":"Molina Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Shuchleib Cukiert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Berumen-Glinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Hern\u00e1ndez-Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Dominguez-Cherit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Toussaint Caire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2944","article-title":"Review on natural killer\/T-cell lymphoma","volume":"41","author":"He X","year":"2023","unstructured":"He X, Gao Y, Li Z, Huang H. Review on natural killer\/T-cell lymphoma. Hematol Oncol. 2023, 41:221-9. 10.1002\/hon.2944","journal-title":"Hematol Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0271","article-title":"Epstein-Barr virus-associated lymphomas","volume":"372","author":"Shannon-Lowe C","year":"2017","unstructured":"Shannon-Lowe C, Rickinson AB, Bell AI. Epstein-Barr virus-associated lymphomas. Philos Trans R Soc Lond B Biol Sci. 2017, 372:20160271. 10.1098\/rstb.2016.0271","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref3","article-title":"Cutaneous involvement of extranodal NK\/T cell lymphoma, nasal type, a clinical and histopathological mimicker of various skin diseases","volume":"9","author":"Ngamdamrongkiat P","year":"2022","unstructured":"Ngamdamrongkiat P, Sukpanichnant S, Chairatchaneeboon M, Khuhapinant A, Sitthinamsuwan P. Cutaneous involvement of extranodal NK\/T cell lymphoma, nasal type, a clinical and histopathological mimicker of various skin diseases. Dermatopathology (Basel). 2022, 9:307-20.","journal-title":"Dermatopathology (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of Haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio R","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, et al.. The 5th edition of the World Health Organization classification of Haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022, 36:1720-48. 10.1038\/s41375-022-01620-2","journal-title":"Leukemia"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1206465","article-title":"Diagnosis and management of extranodal NK\/T cell lymphoma nasal type","volume":"9","author":"Tse E","year":"2016","unstructured":"Tse E, Kwong YL. Diagnosis and management of extranodal NK\/T cell lymphoma nasal type. Expert Rev Hematol. 2016, 9:861-71. 10.1080\/17474086.2016.1206465","journal-title":"Expert Rev Hematol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.704962","article-title":"How to identify patients at high risk of developing nasal-type, extranodal nature killer\/T-cell lymphoma-associated hemophagocytic syndrome","volume":"11","author":"Li N","year":"2021","unstructured":"Li N, Jiang M, Wu WC, Wei WW, Zou LQ. How to identify patients at high risk of developing nasal-type, extranodal nature killer\/T-cell lymphoma-associated hemophagocytic syndrome. Front Oncol. 2021, 11:704962. 10.3389\/fonc.2021.704962","journal-title":"Front Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15972","article-title":"Clinicopathological and prognostic study of primary cutaneous extranodal natural killer\/T-cell lymphoma, nasal type: a systematic review","volume":"48","author":"Jung JM","year":"2021","unstructured":"Jung JM, Yang HJ, Won CH, Chang SE, Lee MW, Lee WJ. Clinicopathological and prognostic study of primary cutaneous extranodal natural killer\/T-cell lymphoma, nasal type: a systematic review. J Dermatol. 2021, 48:1499-510. 10.1111\/1346-8138.15972","journal-title":"J Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"Willemze R","year":"2005","unstructured":"Willemze R, Jaffe ES, Burg G, et al.. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005, 105:3768-85. 10.1182\/blood-2004-09-3502","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-453233","article-title":"How I treat NK\/T-cell lymphomas","volume":"121","author":"Tse E","year":"2013","unstructured":"Tse E, Kwong YL. How I treat NK\/T-cell lymphomas. Blood. 2013, 121:4997-5005. 10.1182\/blood-2013-01-453233","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of mature lymphoid neoplasms: a report from the Clinical Advisory Committee","volume":"140","author":"Campo E","year":"2022","unstructured":"Campo E, Jaffe ES, Cook JR, et al.. The International Consensus Classification of mature lymphoid neoplasms: a report from the Clinical Advisory Committee. Blood. 2022, 140:1229-53.","journal-title":"Blood"},{"key":"ref11","unstructured":"WHO Classification of Tumors. (2025). Accessed. April 8, 2025: https:\/\/tumourclassification.iarc.who.int\/login?redirecturl=%2Fchaptercontent%2F64%2F215."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00002-2","article-title":"Risk stratification on the basis of 18F-FDG PET\/CT for stage I\/II extranodal natural killer\/T-cell lymphoma: a multicentre study","volume":"49","author":"Kim SJ","year":"2013","unstructured":"Kim SJ, Choi JY, Hyun SH, et al.. Risk stratification on the basis of 18F-FDG PET\/CT for stage I\/II extranodal natural killer\/T-cell lymphoma: a multicentre study. Eur J Cancer. 2013, 49:1771-9. 10.1016\/S2352-3026(15)00002-2","journal-title":"Eur J Cancer"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0726-2","article-title":"Treatment of advanced extranodal NK\/T cell lymphoma, nasal-type and aggressive NK-cell leukemia","volume":"92","author":"Suzuki R","year":"2010","unstructured":"Suzuki R. Treatment of advanced extranodal NK\/T cell lymphoma, nasal-type and aggressive NK-cell leukemia. Int J Hematol. 2010, 92:697-701. 10.1007\/s12185-010-0726-2","journal-title":"Int J Hematol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00533-1","article-title":"A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis","volume":"17","author":"Kim SJ","year":"2016","unstructured":"Kim SJ, Yoon DH, Jaccard A, et al.. A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis. Lancet Oncol. 2016, 17:389-400. 10.1016\/S1470-2045(15)00533-1","journal-title":"Lancet Oncol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29023","article-title":"Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma","volume":"121","author":"Chen YB","year":"2015","unstructured":"Chen YB, Batchelor T, Li S, et al.. Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma. Cancer. 2015, 121:226-33. 10.1002\/cncr.29023","journal-title":"Cancer"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.51.21","article-title":"The diagnosis and management of extranodal NK\/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia","volume":"51","author":"Kwong YL","year":"2011","unstructured":"Kwong YL. The diagnosis and management of extranodal NK\/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia. J Clin Exp Hematop. 2011, 51:21-8. 10.3960\/jslrt.51.21","journal-title":"J Clin Exp Hematop"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0341-7","article-title":"PD-L1 is upregulated by EBV-driven LMP1 through NF-\u03baB pathway and correlates with poor prognosis in natural killer\/T-cell lymphoma","volume":"9","author":"Bi XW","year":"2016","unstructured":"Bi XW, Wang H, Zhang WW, et al.. PD-L1 is upregulated by EBV-driven LMP1 through NF-\u03baB pathway and correlates with poor prognosis in natural killer\/T-cell lymphoma. J Hematol Oncol. 2016, 9:109. 10.1186\/s13045-016-0341-7","journal-title":"J Hematol Oncol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2608","article-title":"EBV-driven LMP1 and IFN-\u03b3 up-regulate PD-L1 in nasopharyngeal carcinoma: implications for oncotargeted therapy","volume":"5","author":"Fang W","year":"2014","unstructured":"Fang W, Zhang J, Hong S, et al.. EBV-driven LMP1 and IFN-\u03b3 up-regulate PD-L1 in nasopharyngeal carcinoma: implications for oncotargeted therapy. Oncotarget. 2014, 5:12189-202. 10.18632\/oncotarget.2608","journal-title":"Oncotarget"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-12-756841","article-title":"PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK\/T-cell lymphoma failing l-asparaginase","volume":"129","author":"Kwong YL","year":"2017","unstructured":"Kwong YL, Chan TS, Tan D, et al.. PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK\/T-cell lymphoma failing l-asparaginase. Blood. 2017, 129:2437-42. 10.1182\/blood-2016-12-756841","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2359-2","article-title":"CD38 expression predicts poor prognosis and might be a potential therapy target in extranodal NK\/T cell lymphoma, nasal type","volume":"94","author":"Wang L","year":"2015","unstructured":"Wang L, Wang H, Li PF, Lu Y, Xia ZJ, Huang HQ, Zhang YJ. CD38 expression predicts poor prognosis and might be a potential therapy target in extranodal NK\/T cell lymphoma, nasal type. Ann Hematol. 2015, 94:1381-8. 10.1007\/s00277-015-2359-2","journal-title":"Ann Hematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/416604-extranodal-natural-killert-cell-lymphoma-with-skin-involvement-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T16:47:14Z","timestamp":1767458834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/416604-extranodal-natural-killert-cell-lymphoma-with-skin-involvement-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,3]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.100695","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,3]]}}}