{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:08:11Z","timestamp":1767686891093,"version":"3.48.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"DOI":"10.7759\/cureus.100886","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:03:56Z","timestamp":1767686636000},"source":"Crossref","is-referenced-by-count":0,"title":["Oryza Ceramax in Dermatologic Care: A Multi-pathway Approach to Skin Hydration and Barrier Repair"],"prefix":"10.7759","author":[{"given":"Abhishek","family":"De","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.N.","family":"Sarveswari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Tolat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunaina","family":"Hameed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onkar C","family":"Swami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llae077","article-title":"Lifetime prevalence and associated factors of itch with skin conditions: atopic dermatitis, psoriasis and dry skin in individuals aged > 50\u2005years","volume":"49","author":"Bollemeijer JF","year":"2024","unstructured":"Bollemeijer JF, Zheng KJ, van der Meer AM, et al.. Lifetime prevalence and associated factors of itch with skin conditions: atopic dermatitis, psoriasis and dry skin in individuals aged &gt; 50\u2005years. Clin Exp Dermatol. 2024, 49:1036-43. 10.1093\/ced\/llae077","journal-title":"Clin Exp Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2023.09.018","article-title":"The prevalence and interventions of xerosis cutis among older adults: a systematic review and meta-analysis","volume":"54","author":"Yao D","year":"2023","unstructured":"Yao D, Gong X, Ma Y, Gong T, Wang G. The prevalence and interventions of xerosis cutis among older adults: a systematic review and meta-analysis. Geriatr Nurs. 2023, 54:219-28. 10.1016\/j.gerinurse.2023.09.018","journal-title":"Geriatr Nurs"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13301","article-title":"The effect of environmental humidity and temperature on skin barrier function and dermatitis","volume":"30","author":"Engebretsen KA","year":"2016","unstructured":"Engebretsen KA, Johansen JD, Kezic S, Linneberg A, Thyssen JP. The effect of environmental humidity and temperature on skin barrier function and dermatitis. J Eur Acad Dermatol Venereol. 2016, 30:223-49. 10.1111\/jdv.13301","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4236\/JCDSA.2014.41006","article-title":"Clinical evaluation of moisturizers with physiological analysis of stratum corneum TARC and TSLP","volume":"4","author":"Fukushima S","year":"2014","unstructured":"Fukushima S, Morita E, Tanioka M, Miyachi Y, Murakami Y, Matsunaka H, Ihn H. Clinical evaluation of moisturizers with physiological analysis of stratum corneum TARC and TSLP. J Cosmet Dermatol Sci Appl. 2014, 4:37-43. 10.4236\/JCDSA.2014.41006","journal-title":"J Cosmet Dermatol Sci Appl"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16297","article-title":"Climate change, the cutaneous microbiome and skin disease: implications for a warming world","volume":"62","author":"Isler MF","year":"2023","unstructured":"Isler MF, Coates SJ, Boos MD. Climate change, the cutaneous microbiome and skin disease: implications for a warming world. Int J Dermatol. 2023, 62:337-45. 10.1111\/ijd.16297","journal-title":"Int J Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.21037\/jmai-24-71","article-title":"Skin health response to climate change weather tailored cosmetics using artificial intelligence","volume":"7","author":"Lee J","year":"2024","unstructured":"Lee J, Kwon KH. Skin health response to climate change weather tailored cosmetics using artificial intelligence. J Med Artif Intell. 2024, 7:20. 10.21037\/jmai-24-71","journal-title":"J Med Artif Intell"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-27606-4_35","article-title":"The influence of climate on the treatment of dry skin with moisturizer","author":"Stick C","unstructured":"Stick C, Proksch E. The influence of climate on the treatment of dry skin with moisturizer. Treatment of Dry Skin Syndrome. Lod\u00e9n M, Maibach H (ed): Springer, Berlin, Heidelberg; 503-11. 10.1007\/978-3-642-27606-4_35"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.182427","article-title":"Moisturizers: the slippery road","volume":"61","author":"Sethi A","year":"2016","unstructured":"Sethi A, Kaur T, Malhotra SK, Gambhir ML. Moisturizers: the slippery road. Indian J Dermatol. 2016, 61:279-87. 10.4103\/0019-5154.182427","journal-title":"Indian J Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2020.11.001","article-title":"Air pollution and skin disorders","volume":"7","author":"Roberts W","year":"2021","unstructured":"Roberts W. Air pollution and skin disorders. Int J Womens Dermatol. 2021, 7:91-7. 10.1016\/j.ijwd.2020.11.001","journal-title":"Int J Womens Dermatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14217","article-title":"A new era of moisturizers","volume":"20","author":"Chandan N","year":"2021","unstructured":"Chandan N, Rajkumar JR, Shi VY, Lio PA. A new era of moisturizers. J Cosmet Dermatol. 2021, 20:2425-30. 10.1111\/jocd.14217","journal-title":"J Cosmet Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000493641","article-title":"Moisturizers versus current and next-generation barrier repair therapy for the management of atopic dermatitis","volume":"32","author":"Elias PM","year":"2019","unstructured":"Elias PM, Wakefield JS, Man MQ. Moisturizers versus current and next-generation barrier repair therapy for the management of atopic dermatitis. Skin Pharmacol Physiol. 2019, 32:1-7. 10.1159\/000493641","journal-title":"Skin Pharmacol Physiol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2017.1363","article-title":"The role of moisturizers in addressing various kinds of dermatitis: a review","volume":"15","author":"Purnamawati S","year":"2017","unstructured":"Purnamawati S, Satria B, Indrastuti N, Danarti R, Saefudin T. The role of moisturizers in addressing various kinds of dermatitis: a review. Clin Med Res. 2017, 15:75-87. 10.3121\/cmr.2017.1363","journal-title":"Clin Med Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13090","article-title":"The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment","volume":"32","author":"Lueangarun S","year":"2019","unstructured":"Lueangarun S, Tragulplaingam P, Sugkraroek S, Tempark T. The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment. Dermatol Ther. 2019, 32:e13090. 10.1111\/dth.13090","journal-title":"Dermatol Ther"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch E","year":"2008","unstructured":"Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008, 17:1063-72. 10.1111\/j.1600-0625.2008.00786.x","journal-title":"Exp Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2018.10.3.207","article-title":"Significance of skin barrier dysfunction in atopic dermatitis","volume":"10","author":"Kim BE","year":"2018","unstructured":"Kim BE, Leung DY. Significance of skin barrier dysfunction in atopic dermatitis. Allergy Asthma Immunol Res. 2018, 10:207-15. 10.4168\/aair.2018.10.3.207","journal-title":"Allergy Asthma Immunol Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/cells12242793","article-title":"Cytokines and epidermal lipid abnormalities in atopic dermatitis: a systematic review","volume":"12","author":"Upadhyay PR","year":"2023","unstructured":"Upadhyay PR, Seminario-Vidal L, Abe B, Ghobadi C, Sims JT. Cytokines and epidermal lipid abnormalities in atopic dermatitis: a systematic review. Cells. 2023, 12:2793. 10.3390\/cells12242793","journal-title":"Cells"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00619-2","article-title":"Ceramides in skin health and disease: an update","volume":"22","author":"Uchida Y","year":"2021","unstructured":"Uchida Y, Park K. Ceramides in skin health and disease: an update. Am J Clin Dermatol. 2021, 22:853-66. 10.1007\/s40257-021-00619-2","journal-title":"Am J Clin Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14970","article-title":"A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: a randomized trial","volume":"34","author":"Spada F","year":"2021","unstructured":"Spada F, Harrison IP, Barnes TM, et al.. A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: a randomized trial. Dermatol Ther. 2021, 34:e14970. 10.1111\/dth.14970","journal-title":"Dermatol Ther"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.3046","article-title":"Consumer preferences, product characteristics, and potentially allergenic ingredients in best-selling moisturizers","volume":"153","author":"Xu S","year":"2017","unstructured":"Xu S, Kwa M, Lohman ME, Evers-Meltzer R, Silverberg JI. Consumer preferences, product characteristics, and potentially allergenic ingredients in best-selling moisturizers. JAMA Dermatol. 2017, 153:1099-105. 10.1001\/jamadermatol.2017.3046","journal-title":"JAMA Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58070888","article-title":"Moisturizer in patients with inflammatory skin diseases","volume":"58","author":"Kang SY","year":"2022","unstructured":"Kang SY, Um JY, Chung BY, et al.. Moisturizer in patients with inflammatory skin diseases. Medicina (Kaunas). 2022, 58:888. 10.3390\/medicina58070888","journal-title":"Medicina (Kaunas)"},{"key":"ref21","article-title":"Aquaporins: an introduction to a key factor in the mechanism of skin hydration","volume":"5","author":"Draelos Z","year":"2012","unstructured":"Draelos Z. Aquaporins: an introduction to a key factor in the mechanism of skin hydration. J Clin Aesthet Dermatol. 2012, 5:53-6.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-7415-1_15","article-title":"Aquaporins in skin","author":"Yin Z","year":"2023","unstructured":"Yin Z, Ren H. Aquaporins in skin. Aquaporins. Advances in Experimental Medicine and Biology. Yang B (ed): Springer, Singapore; 2023. 211-23. 10.1007\/978-981-19-7415-1_15"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000338190","article-title":"Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin","volume":"25","author":"Schrader A","year":"2012","unstructured":"Schrader A, Siefken W, Kueper T, et al.. Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin. Skin Pharmacol Physiol. 2012, 25:192-9. 10.1159\/000338190","journal-title":"Skin Pharmacol Physiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19162","article-title":"Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes","volume":"184","author":"El-Chami C","year":"2021","unstructured":"El-Chami C, Foster AR, Johnson C, et al.. Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes. Br J Dermatol. 2021, 184:482-94. 10.1111\/bjd.19162","journal-title":"Br J Dermatol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4796","article-title":"The effect of a ceramide-containing product on stratum corneum lipid levels in dry legs","volume":"19","author":"Draelos ZD","year":"2020","unstructured":"Draelos ZD, Baalbaki NH, Cook S, Raab S, Col\u00f3n G. The effect of a ceramide-containing product on stratum corneum lipid levels in dry legs. J Drugs Dermatol. 2020, 19:372-6. 10.36849\/JDD.2020.4796","journal-title":"J Drugs Dermatol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANAI.2022.01.012","article-title":"Optimizing emollient therapy for skin barrier repair in atopic dermatitis","volume":"128","author":"Elias PM","year":"2022","unstructured":"Elias PM. Optimizing emollient therapy for skin barrier repair in atopic dermatitis. Ann Allergy Asthma Immunol. 2022, 128:505-11. 10.1016\/J.ANAI.2022.01.012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref27","article-title":"The basics of skin care: cleanse, moisturize, protect","volume":"2","author":"McLeod RP","year":"2013","unstructured":"McLeod RP, Horowitz P, Fowler JF, Eichenfield LF, Elias PM. The basics of skin care: cleanse, moisturize, protect. Semin Cutan Med Surg. 2013, 2:30-2.","journal-title":"Semin Cutan Med Surg"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.11.009","article-title":"Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology\/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE- and Institute of Medicine-based recommendations","volume":"132","author":"Chu DK","year":"2024","unstructured":"Chu DK, Schneider L, Asiniwasis RN, et al.. Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology\/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE- and Institute of Medicine-based recommendations. Ann Allergy Asthma Immunol. 2024, 132:274-312. 10.1016\/j.anai.2023.11.009","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.5.563","article-title":"Consensus guidelines for the treatment of atopic dermatitis in Korea (part I): general management and topical treatment","volume":"27","author":"Kim JE","year":"2015","unstructured":"Kim JE, Kim HJ, Lew BL, et al.. Consensus guidelines for the treatment of atopic dermatitis in Korea (part I): general management and topical treatment. Ann Dermatol. 2015, 27:563-77. 10.5021\/ad.2015.27.5.563","journal-title":"Ann Dermatol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/J.1468-3083.2009.03415.X","article-title":"ETFAD\/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis","volume":"24","author":"Darsow U","year":"2010","unstructured":"Darsow U, Wollenberg A, Simon D, et al.. ETFAD\/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis. J Eur Acad Dermatol Venereol. 2010, 24:317-28. 10.1111\/J.1468-3083.2009.03415.X","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16892","article-title":"ETFAD\/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children","volume":"34","author":"Wollenberg A","year":"2020","unstructured":"Wollenberg A, Christen-Z\u00e4ch S, Taieb A, et al.. ETFAD\/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. J Eur Acad Dermatol Venereol. 2020, 34:2717-44. 10.1111\/jdv.16892","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040617","article-title":"Patient-centric design of topical dermatological medicines","volume":"16","author":"Oliveira R","year":"2023","unstructured":"Oliveira R, Almeida IF. Patient-centric design of topical dermatological medicines. Pharmaceuticals (Basel). 2023, 16:617. 10.3390\/ph16040617","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-3","article-title":"A phase I study of daily treatment with a ceramide-dominant triple lipid mixture commencing in neonates","volume":"12","author":"Lowe AJ","year":"2012","unstructured":"Lowe AJ, Tang ML, Dharmage SC, et al.. A phase I study of daily treatment with a ceramide-dominant triple lipid mixture commencing in neonates. BMC Dermatol. 2012, 12:3. 10.1186\/1471-5945-12-3","journal-title":"BMC Dermatol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8454","article-title":"Aquaporin-3-mediated hydrogen peroxide transport is required for NF-\u03baB signalling in keratinocytes and development of psoriasis","volume":"6","author":"Hara-Chikuma M","year":"2015","unstructured":"Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, Verkman AS. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-\u03baB signalling in keratinocytes and development of psoriasis. Nat Commun. 2015, 6:7454. 10.1038\/ncomms8454","journal-title":"Nat Commun"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2023.4526","article-title":"The relationship between aquaporins and skin diseases","volume":"33","author":"Liu J","year":"2023","unstructured":"Liu J, Jin Y, Wei Q, et al.. The relationship between aquaporins and skin diseases. Eur J Dermatol. 2023, 33:350-9. 10.1684\/ejd.2023.4526","journal-title":"Eur J Dermatol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29071540","article-title":"Synergetic effects of aloe vera extract with trimethylglycine for targeted aquaporin 3 regulation and long-term skin hydration","volume":"29","author":"Filatov V","year":"2024","unstructured":"Filatov V, Sokolova A, Savitskaya N, Olkhovskaya M, Varava A, Ilin E, Patronova E. Synergetic effects of aloe vera extract with trimethylglycine for targeted aquaporin 3 regulation and long-term skin hydration. Molecules. 2024, 29:1540. 10.3390\/molecules29071540","journal-title":"Molecules"},{"key":"ref37","article-title":"Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide","volume":"5","author":"Weber TM","year":"2012","unstructured":"Weber TM, Kausch M, Rippke F, Schoelermann AM, Filbry AW. Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide. J Clin Aesthet Dermatol. 2012, 5:29-39.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S177697","article-title":"Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems","volume":"11","author":"Spada F","year":"2018","unstructured":"Spada F, Barnes TM, Greive KA. Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clin Cosmet Investig Dermatol. 2018, 11:491-7. 10.2147\/CCID.S177697","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref39","article-title":"Original papers The influence of emollient Eucerin\u00ae Soothing lotion 12% Omega on transepidermal water loss, moisturization of epidermis and skin elasticity in children with atopic dermatitis. (Article in Polish)","volume":"26","author":"Silny W","year":"2009","unstructured":"Silny W, Czarnecka-Operator M, Hasse-Cie\u015bli\u0144ska M, Marciniak A, Olek-Hrab K. Original papers The influence of emollient Eucerin\u00ae Soothing lotion 12% Omega on transepidermal water loss, moisturization of epidermis and skin elasticity in children with atopic dermatitis. (Article in Polish). Post Dermatol Allergol. 2009, 26:8-16.","journal-title":"Post Dermatol Allergol"},{"key":"ref40","unstructured":"HERA. Human and Environmental Risk Assessment on ingredients of European household cleaning products: Cocamidopropyl betaine (CAPB). (2005). Accessed: November 28, 2025: http:\/\/www.ccia-cleaning.org\/uploadfile\/2011\/0627\/20110627013433890.pdf."},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.06043","article-title":"Cocamidopropyl betaine","volume":"19","author":"Jacob SE","year":"2008","unstructured":"Jacob SE, Amini S. Cocamidopropyl betaine. Dermatitis. 2008, 19:157-60. 10.2310\/6620.2008.06043","journal-title":"Dermatitis"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/J.HERMED.2023.100629","article-title":"Evaluation of saffron extract bioactivities relevant to skin resilience","volume":"37","author":"Xiong J","year":"2023","unstructured":"Xiong J, Grace MH, Kobayashi H, Lila MA. Evaluation of saffron extract bioactivities relevant to skin resilience. J Herb Med. 2023, 37:100629. 10.1016\/J.HERMED.2023.100629","journal-title":"J Herb Med"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.18051\/UNIVMED.2024.V43.329-339","article-title":"The effect of saffron serum on collagen density, inflammatory gene expression, and autophagy in UVB-exposed Wistar rats","volume":"43","author":"Octavia C","year":"2024","unstructured":"Octavia C, Gunadi JW, Adhika OA, Ishak L, Jasaputra DK, Rosali AE, Sanjaya A. The effect of saffron serum on collagen density, inflammatory gene expression, and autophagy in UVB-exposed Wistar rats. Universa Medicina. 2024, 43:329-39. 10.18051\/UNIVMED.2024.V43.329-339","journal-title":"Universa Medicina"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818638-1.00016-2","article-title":"Bioactive ingredients of saffron: extraction, analysis, applications","author":"Jafari SM","year":"2020","unstructured":"Jafari SM, Tsimidou MZ, Rajabi H, Kyriakoudi A. Bioactive ingredients of saffron: extraction, analysis, applications. Saffron. Koocheki A, Khajeh-Hosseini M (ed): Woodhead Publishing, 2020. 262-90. 10.1016\/B978-0-12-818638-1.00016-2"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.14710\/DMJ.V12I6.40711","article-title":"Literature review: the role of saffron (Crocus sativus L) in cosmetic dermatology","volume":"12","author":"Damayanti GS","year":"2023","unstructured":"Damayanti GS, Riyanto P. Literature review: the role of saffron (Crocus sativus L) in cosmetic dermatology. Diponegoro Med J. 2023, 12:375-82. 10.14710\/DMJ.V12I6.40711","journal-title":"Diponegoro Med J"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00566-0","article-title":"Efficacy evaluation of a topical hyaluronic acid serum in facial photoaging","volume":"11","author":"Draelos ZD","year":"2021","unstructured":"Draelos ZD, Diaz I, Namkoong J, Wu J, Boyd T. Efficacy evaluation of a topical hyaluronic acid serum in facial photoaging. Dermatol Ther (Heidelb). 2021, 11:1385-94. 10.1007\/s13555-021-00566-0","journal-title":"Dermatol Ther (Heidelb)"},{"key":"ref47","article-title":"Efficacy and safety of a low molecular weight hyaluronic acid topical gel in the treatment of facial seborrheic dermatitis final report","volume":"7","author":"Schlesinger T","year":"2014","unstructured":"Schlesinger T, Rowland Powell C. Efficacy and safety of a low molecular weight hyaluronic acid topical gel in the treatment of facial seborrheic dermatitis final report. J Clin Aesthet Dermatol. 2014, 7:15-8.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/J.MEDNTD.2024.100320","article-title":"Recent applications and molecular mechanisms of hyaluronic acid in skin aging and wound healing","volume":"23","author":"Shang L","year":"2024","unstructured":"Shang L, Li M, Xu A, Zhuo F. Recent applications and molecular mechanisms of hyaluronic acid in skin aging and wound healing. Med Nov Technol Devices. 2024, 23:100320. 10.1016\/J.MEDNTD.2024.100320","journal-title":"Med Nov Technol Devices"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15903","article-title":"Benefits of topical hyaluronic acid for skin quality and signs of skin aging: from literature review to clinical evidence","volume":"35","author":"Bravo B","year":"2022","unstructured":"Bravo B, Correia P, Gon\u00e7alves Junior JE, Sant'Anna B, Kerob D. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: from literature review to clinical evidence. Dermatol Ther. 2022, 35:e15903. 10.1111\/dth.15903","journal-title":"Dermatol Ther"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7142","article-title":"Ceramide-containing adjunctive skin care for skin barrier restoration during acne vulgaris treatment","volume":"22","author":"Draelos ZD","year":"2023","unstructured":"Draelos ZD, Baalbaki N, Colon G, Dreno B. Ceramide-containing adjunctive skin care for skin barrier restoration during acne vulgaris treatment. J Drugs Dermatol. 2023, 22:554-8. 10.36849\/JDD.7142","journal-title":"J Drugs Dermatol"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29002.flf","article-title":"Effectiveness of a skin care program with a cream containing ceramide C and a personalized training for secondary prevention of hand contact dermatitis","volume":"34","author":"Filon FL","year":"2023","unstructured":"Filon FL, Maculan P, Crivellaro MA, Mauro M. Effectiveness of a skin care program with a cream containing ceramide C and a personalized training for secondary prevention of hand contact dermatitis. Dermatitis. 2023, 34:127-34. 10.1089\/derm.2022.29002.flf","journal-title":"Dermatitis"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.5021\/ad.24.153","article-title":"Consensus-based guidelines for the treatment of atopic dermatitis in Korea (part I): basic therapy, topical therapy, and conventional systemic therapy","volume":"37","author":"Ko HC","year":"2025","unstructured":"Ko HC, Woo YR, Ko JY, et al.. Consensus-based guidelines for the treatment of atopic dermatitis in Korea (part I): basic therapy, topical therapy, and conventional systemic therapy. Ann Dermatol. 2025, 37:201-15. 10.5021\/ad.24.153","journal-title":"Ann Dermatol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.00150.x","article-title":"Is mineral oil comedogenic?","volume":"4","author":"DiNardo JC","year":"2005","unstructured":"DiNardo JC. Is mineral oil comedogenic?. J Cosmet Dermatol. 2005, 4:2-3. 10.1111\/j.1473-2165.2005.00150.x","journal-title":"J Cosmet Dermatol"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3390\/COSMETICS8030069","article-title":"Towards optimal pH of the skin and topical formulations: from the current state of the art to tailored products","volume":"8","author":"Luki\u0107 M","year":"2021","unstructured":"Luki\u0107 M, Panteli\u0107 I, Savi\u0107 SD. Towards optimal pH of the skin and topical formulations: from the current state of the art to tailored products. Cosmetics. 2021, 8:69. 10.3390\/COSMETICS8030069","journal-title":"Cosmetics"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/392997-oryza-ceramax-in-dermatologic-care-a-multi-pathway-approach-to-skin-hydration-and-barrier-repair","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:04:00Z","timestamp":1767686640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/392997-oryza-ceramax-in-dermatologic-care-a-multi-pathway-approach-to-skin-hydration-and-barrier-repair"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":54,"URL":"https:\/\/doi.org\/10.7759\/cureus.100886","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,6]]}}}