{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:09:42Z","timestamp":1774314582915,"version":"3.50.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"DOI":"10.7759\/cureus.100987","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:26:27Z","timestamp":1767788787000},"source":"Crossref","is-referenced-by-count":1,"title":["Statin-Associated Immune-Mediated Necrotizing Myopathy Presenting as Persistent Hypertransaminasemia"],"prefix":"10.7759","author":[{"given":"Rita","family":"Bragan\u00e7a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Ferreira da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Macedo Br\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102993","article-title":"Immune-mediated necrotizing myopathy (IMNM): a myopathological challenge","volume":"21","author":"Merlonghi G","year":"2022","unstructured":"Merlonghi G, Antonini G, Garibaldi M. Immune-mediated necrotizing myopathy (IMNM): a myopathological challenge. Autoimmun Rev. 2022, 21:102993. 10.1016\/j.autrev.2021.102993","journal-title":"Autoimmun Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00515-9","article-title":"Immune-mediated necrotizing myopathy: clinical features and pathogenesis","volume":"16","author":"Allenbach Y","year":"2020","unstructured":"Allenbach Y, Benveniste O, Stenzel W, Boyer O. Immune-mediated necrotizing myopathy: clinical features and pathogenesis. Nat Rev Rheumatol. 2020, 16:689-701. 10.1038\/s41584-020-00515-9","journal-title":"Nat Rev Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaf238","article-title":"The incidence of anti-HMGCR immune-mediated necrotizing myopathy: an Australian and UK retrospective multi-site cohort study","volume":"64","author":"Khoo T","year":"2025","unstructured":"Khoo T, Tan E, Limaye V, et al.. The incidence of anti-HMGCR immune-mediated necrotizing myopathy: an Australian and UK retrospective multi-site cohort study. Rheumatology (Oxford). 2025, 64:4995-5003. 10.1093\/rheumatology\/keaf238","journal-title":"Rheumatology (Oxford)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/art.30156","article-title":"Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy","volume":"63","author":"Mammen AL","year":"2011","unstructured":"Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Doering KR, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011, 63:713-21. 10.1002\/art.30156","journal-title":"Arthritis Rheum"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27382","article-title":"Statin-associated anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) myopathy: imaging findings on thigh-muscle magnetic resonance imaging (MRI) in six patients","volume":"64","author":"Lee KH","year":"2021","unstructured":"Lee KH, Gao Y, Lau V. Statin-associated anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) myopathy: imaging findings on thigh-muscle magnetic resonance imaging (MRI) in six patients. Muscle Nerve. 2021, 64:500-4. 10.1002\/mus.27382","journal-title":"Muscle Nerve"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.07.023","article-title":"Anti-HMGCR antibodies as a biomarker for immune-mediated necrotizing myopathies: a history of statins and experience from a large international multi-center study","volume":"15","author":"Musset L","year":"2016","unstructured":"Musset L, Allenbach Y, Benveniste O, et al.. Anti-HMGCR antibodies as a biomarker for immune-mediated necrotizing myopathies: a history of statins and experience from a large international multi-center study. Autoimmun Rev. 2016, 15:983-93. 10.1016\/j.autrev.2016.07.023","journal-title":"Autoimmun Rev"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000335","article-title":"Spectrum of immune-mediated necrotizing myopathies and their treatments","volume":"28","author":"Pinal-Fernandez I","year":"2016","unstructured":"Pinal-Fernandez I, Mammen AL. Spectrum of immune-mediated necrotizing myopathies and their treatments. Curr Opin Rheumatol. 2016, 28:619-24. 10.1097\/BOR.0000000000000335","journal-title":"Curr Opin Rheumatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew470","article-title":"More severe disease and slower recovery in younger patients with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy","volume":"56","author":"Tiniakou E","year":"2017","unstructured":"Tiniakou E, Pinal-Fernandez I, Lloyd TE, et al.. More severe disease and slower recovery in younger patients with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Rheumatology (Oxford). 2017, 56:787-94. 10.1093\/rheumatology\/kew470","journal-title":"Rheumatology (Oxford)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i10.1020","article-title":"Abnormal liver function tests associated with severe rhabdomyolysis","volume":"26","author":"Lim AK","year":"2020","unstructured":"Lim AK. Abnormal liver function tests associated with severe rhabdomyolysis. World J Gastroenterol. 2020, 26:1020-8. 10.3748\/wjg.v26.i10.1020","journal-title":"World J Gastroenterol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010310","article-title":"Markedly elevated aspartate aminotransferase from non-hepatic causes","volume":"12","author":"Han JH","year":"2022","unstructured":"Han JH, Kwak JY, Lee SS, Kim HG, Jeon H, Cha RR. Markedly elevated aspartate aminotransferase from non-hepatic causes. J Clin Med. 2022, 12:310. 10.3390\/jcm12010310","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1179\/146532806X152872","article-title":"Incidental raised transaminases: a clue to muscle disease","volume":"26","author":"Urganci N","year":"2006","unstructured":"Urganci N, Arapo\u011flu M, Serdaro\u011flu P, Nuho\u011flu A. Incidental raised transaminases: a clue to muscle disease. Ann Trop Paediatr. 2006, 26:345-8. 10.1179\/146532806X152872","journal-title":"Ann Trop Paediatr"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000434673.85515.89","article-title":"The spectrum of statin myopathy","volume":"25","author":"Mohassel P","year":"2013","unstructured":"Mohassel P, Mammen AL. The spectrum of statin myopathy. Curr Opin Rheumatol. 2013, 25:747-52. 10.1097\/01.bor.0000434673.85515.89","journal-title":"Curr Opin Rheumatol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40674-023-00210-2","article-title":"Treatment of immune-mediated necrotizing myopathy","volume":"9","author":"Ogbonnaya-Whittlesey SA","year":"2023","unstructured":"Ogbonnaya-Whittlesey SA, Kobrin D, Casal-Dominguez M, Mammen AL, Pinal-Fernandez I. Treatment of immune-mediated necrotizing myopathy. Curr Treatm Opt Rheumatol. 2023, 9:168-78. 10.1007\/s40674-023-00210-2","journal-title":"Curr Treatm Opt Rheumatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/450462-statin-associated-immune-mediated-necrotizing-myopathy-presenting-as-persistent-hypertransaminasemia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:26:28Z","timestamp":1767788788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/450462-statin-associated-immune-mediated-necrotizing-myopathy-presenting-as-persistent-hypertransaminasemia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.100987","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,7]]}}}