{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:20:46Z","timestamp":1790871646224,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,11]]},"DOI":"10.7759\/cureus.101299","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T23:41:32Z","timestamp":1768174892000},"source":"Crossref","is-referenced-by-count":3,"title":["Role of Exercise in Fibromyalgia Management: A Narrative Review of Mechanisms, Modalities, and Clinical Evidence"],"prefix":"10.7759","author":[{"given":"Alexander","family":"Mazzorana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laith","family":"Fada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wahidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.22","article-title":"Fibromyalgia","volume":"1","author":"H\u00e4user W","year":"2015","unstructured":"H\u00e4user W, Ablin J, Fitzcharles MA, Littlejohn G, Luciano JV, Usui C, Walitt B. Fibromyalgia. Nat Rev Dis Primers. 2015, 1:15022. 10.1038\/nrdp.2015.22","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012","article-title":"2016 revisions to the 2010\/2011 fibromyalgia diagnostic criteria","volume":"46","author":"Wolfe F","year":"2016","unstructured":"Wolfe F, Clauw DJ, Fitzcharles MA, et al.. 2016 revisions to the 2010\/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016, 46:319-29. 10.1016\/j.semarthrit.2016.08.012","journal-title":"Semin Arthritis Rheum"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209724","article-title":"EULAR revised recommendations for the management of fibromyalgia","volume":"76","author":"Macfarlane GJ","year":"2017","unstructured":"Macfarlane GJ, Kronisch C, Dean LE, et al.. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017, 76:318-28. 10.1136\/annrheumdis-2016-209724","journal-title":"Ann Rheum Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0206","article-title":"The science of fibromyalgia","volume":"86","author":"Clauw DJ","year":"2011","unstructured":"Clauw DJ, Arnold LM, McCarberg BH. The science of fibromyalgia. Mayo Clin Proc. 2011, 86:907-11. 10.4065\/mcp.2011.0206","journal-title":"Mayo Clin Proc"},{"key":"ref5","article-title":"The fibromyalgia impact questionnaire: development and validation","volume":"18","author":"Burckhardt CS","year":"1991","unstructured":"Burckhardt CS, Clark SR, Bennett RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol. 1991, 18:728-33.","journal-title":"J Rheumatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235879","article-title":"Altered central pain processing in fibromyalgia-a multimodal neuroimaging case-control study using arterial spin labelling","volume":"16","author":"M\u00fcller M","year":"2021","unstructured":"M\u00fcller M, W\u00fcthrich F, Federspiel A, et al.. Altered central pain processing in fibromyalgia-a multimodal neuroimaging case-control study using arterial spin labelling. PLoS One. 2021, 16:e0235879. 10.1371\/journal.pone.0235879","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083891","article-title":"Fibromyalgia: pathogenesis, mechanisms, diagnosis, and treatment options update","volume":"22","author":"Siracusa R","year":"2021","unstructured":"Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: pathogenesis, mechanisms, diagnosis, and treatment options update. Int J Mol Sci. 2021, 22:3891. 10.3390\/ijms22083891","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2022.35.3.327","article-title":"Relationships of autonomic dysfunction with disease severity and neuropathic pain features in fibromyalgia: is it really a sympathetically maintained neuropathic pain?","volume":"35","author":"On AY","year":"2022","unstructured":"On AY, Tanigor G, Baydar DA. Relationships of autonomic dysfunction with disease severity and neuropathic pain features in fibromyalgia: is it really a sympathetically maintained neuropathic pain?. Korean J Pain. 2022, 35:327-35. 10.3344\/kjp.2022.35.3.327","journal-title":"Korean J Pain"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab146","article-title":"Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis","volume":"60","author":"O'Mahony LF","year":"2021","unstructured":"O'Mahony LF, Srivastava A, Mehta P, Ciurtin C. Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis. Rheumatology (Oxford). 2021, 60:2602-14. 10.1093\/rheumatology\/keab146","journal-title":"Rheumatology (Oxford)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2024.1407445","article-title":"Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain","volume":"17","author":"Zou J","year":"2024","unstructured":"Zou J, Hao S. Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain. Front Mol Neurosci. 2024, 17:1407445. 10.3389\/fnmol.2024.1407445","journal-title":"Front Mol Neurosci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2025.10.023","article-title":"Effect of aerobic exercise on fatigue and quality of life in individuals with fibromyalgia: a systematic review of randomized controlled trials","volume":"48","author":"Carvalho C","year":"2025","unstructured":"Carvalho C, Vass\u00e3o PG, Santos TI, Parisi JR, Garcia-Motta H, Renno AC. Effect of aerobic exercise on fatigue and quality of life in individuals with fibromyalgia: a systematic review of randomized controlled trials. J Manipulative Physiol Ther. 2025, 48:448-59. 10.1016\/j.jmpt.2025.10.023","journal-title":"J Manipulative Physiol Ther"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12071543","article-title":"Fibromyalgia: a review of the pathophysiological mechanisms and multidisciplinary treatment strategies","volume":"12","author":"Jurado-Priego LN","year":"2024","unstructured":"Jurado-Priego LN, Cueto-Ure\u00f1a C, Ram\u00edrez-Exp\u00f3sito MJ, Mart\u00ednez-Martos JM. Fibromyalgia: a review of the pathophysiological mechanisms and multidisciplinary treatment strategies. Biomedicines. 2024, 12:1543. 10.3390\/biomedicines12071543","journal-title":"Biomedicines"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.4783","article-title":"Aerobic exercise prescription for pain reduction in fibromyalgia: a systematic review and meta-analysis","volume":"29","author":"Casanova-Rodr\u00edguez D","year":"2025","unstructured":"Casanova-Rodr\u00edguez D, Ranchal-S\u00e1nchez A, Rodr\u00edguez RB, Jurado-Castro JM. Aerobic exercise prescription for pain reduction in fibromyalgia: a systematic review and meta-analysis. Eur J Pain. 2025, 29:e4783. 10.1002\/ejp.4783","journal-title":"Eur J Pain"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14213-x","article-title":"Effect of different types of exercise in adult subjects with fibromyalgia: a systematic review and meta-analysis of randomised clinical trials","volume":"12","author":"Couto N","year":"2022","unstructured":"Couto N, Monteiro D, Cid L, Bento T. Effect of different types of exercise in adult subjects with fibromyalgia: a systematic review and meta-analysis of randomised clinical trials. Sci Rep. 2022, 12:10391. 10.1038\/s41598-022-14213-x","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012700","article-title":"Aerobic exercise training for adults with fibromyalgia","volume":"6","author":"Bidonde J","year":"2017","unstructured":"Bidonde J, Busch AJ, Schachter CL, et al.. Aerobic exercise training for adults with fibromyalgia. Cochrane Database Syst Rev. 2017, 6:CD012700. 10.1002\/14651858.CD012700","journal-title":"Cochrane Database Syst Rev"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjpt.2025.101226","article-title":"The most effective therapeutic exercises for pain intensity in women with fibromyalgia: a systematic review and network meta-analysis","volume":"29","author":"Rodr\u00edguez-Dom\u00ednguez \u00c1J","year":"2025","unstructured":"Rodr\u00edguez-Dom\u00ednguez \u00c1J, Rebollo-Salas M, Chill\u00f3n-Mart\u00ednez R, Rosales-Tristancho A, Villa-Del-Pino I, Jim\u00e9nez-Rejano JJ. The most effective therapeutic exercises for pain intensity in women with fibromyalgia: a systematic review and network meta-analysis. Braz J Phys Ther. 2025, 29:101226. 10.1016\/j.bjpt.2025.101226","journal-title":"Braz J Phys Ther"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012559","article-title":"The effects of exercise training on mitochondrial function in cardiovascular diseases: a systematic review and meta-analysis","volume":"23","author":"Lim AY","year":"2022","unstructured":"Lim AY, Chen YC, Hsu CC, Fu TC, Wang JS. The effects of exercise training on mitochondrial function in cardiovascular diseases: a systematic review and meta-analysis. Int J Mol Sci. 2022, 23:12559. 10.3390\/ijms232012559","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000002318","article-title":"Effect of resistance exercises on function and pain in fibromyalgia: a systematic review and meta-analysis of randomized controlled trials","volume":"103","author":"Wang JJ","year":"2024","unstructured":"Wang JJ, Tam KW, Hsiao HY, Liou TH, Rau CL, Hsu TH. Effect of resistance exercises on function and pain in fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. Am J Phys Med Rehabil. 2024, 103:275-83. 10.1097\/PHM.0000000000002318","journal-title":"Am J Phys Med Rehabil"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/life15010040","article-title":"Exercise intervention in women with fibromyalgia and its influence on pain, psychological variables, and disability: an observational study","volume":"15","author":"Gonz\u00e1lez-\u00c1lvarez ME","year":"2024","unstructured":"Gonz\u00e1lez-\u00c1lvarez ME, Riquelme-Aguado V, Rossettini G, Fern\u00e1ndez-Carnero J, Villafa\u00f1e JH. Exercise intervention in women with fibromyalgia and its influence on pain, psychological variables, and disability: an observational study. Life (Basel). 2024, 15:40. 10.3390\/life15010040","journal-title":"Life (Basel)"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/physiologia3030034","article-title":"Exploring adherence to moderate- to high-intensity exercises in patients with fibromyalgia: the role of physiological and psychological factors\u2014a narrative literature review","volume":"3","author":"Sarmento C","year":"2023","unstructured":"Sarmento C, Liu Z, Smirnova I, Liu W. Exploring adherence to moderate- to high-intensity exercises in patients with fibromyalgia: the role of physiological and psychological factors\u2014a narrative literature review. Physiologia. 2023, 3:472-83. 10.3390\/physiologia3030034","journal-title":"Physiologia"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-024-07066-4","article-title":"The effectiveness of stretching exercises in patients with fibromyalgia: a systematic review","volume":"43","author":"St\u00f8ve MP","year":"2024","unstructured":"St\u00f8ve MP, Dissing AM, Thomsen JL, Magnusson SP, Riis A. The effectiveness of stretching exercises in patients with fibromyalgia: a systematic review. Clin Rheumatol. 2024, 43:3039-53. 10.1007\/s10067-024-07066-4","journal-title":"Clin Rheumatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177\/0269215519893107","article-title":"Benefits of adding stretching to a moderate-intensity aerobic exercise programme in women with fibromyalgia: a randomized controlled trial","volume":"34","author":"G\u00f3mez-Hern\u00e1ndez M","year":"2020","unstructured":"G\u00f3mez-Hern\u00e1ndez M, Gallego-Izquierdo T, Mart\u00ednez-Merinero P, et al.. Benefits of adding stretching to a moderate-intensity aerobic exercise programme in women with fibromyalgia: a randomized controlled trial. Clin Rehabil. 2020, 34:242-51. 10.1177\/0269215519893107","journal-title":"Clin Rehabil"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnae076","article-title":"Mind-body therapy for treating fibromyalgia: a systematic review","volume":"25","author":"Steen JP","year":"2024","unstructured":"Steen JP, Kannan V, Zaidi A, Cramer H, Ng JY. Mind-body therapy for treating fibromyalgia: a systematic review. Pain Med. 2024, 25:703-37. 10.1093\/pm\/pnae076","journal-title":"Pain Med"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.70044","article-title":"Guidelines on treating fibromyalgia with nonpharmacological therapies in China","volume":"18","author":"Li X","year":"2025","unstructured":"Li X, Pan H, Wang L, et al.. Guidelines on treating fibromyalgia with nonpharmacological therapies in China. J Evid Based Med. 2025, 18:e70044. 10.1111\/jebm.70044","journal-title":"J Evid Based Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/ar3002","article-title":"Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials","volume":"12","author":"H\u00e4user W","year":"2010","unstructured":"H\u00e4user W, Klose P, Langhorst J, Moradi B, Steinbach M, Schiltenwolf M, Busch A. Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials. Arthritis Res Ther. 2010, 12:R79. 10.1186\/ar3002","journal-title":"Arthritis Res Ther"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/447444-role-of-exercise-in-fibromyalgia-management-a-narrative-review-of-mechanisms-modalities-and-clinical-evidence","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T23:41:33Z","timestamp":1768174893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/447444-role-of-exercise-in-fibromyalgia-management-a-narrative-review-of-mechanisms-modalities-and-clinical-evidence"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,11]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.101299","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,11]]}}}