{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:37:08Z","timestamp":1768513028069,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"DOI":"10.7759\/cureus.101570","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:54:43Z","timestamp":1768460083000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of Surface Anesthetics on Tongue Sensory Function"],"prefix":"10.7759","author":[{"given":"Mami","family":"Takemori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Honda-Sakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakana","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieko","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiharu","family":"Shimosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Komiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1993.tb00723.x","article-title":"Burning mouth in a Finnish adult population","volume":"21","author":"Tammiala-Salonen T","year":"1993","unstructured":"Tammiala-Salonen T, Hiidenkari T, Parvinen T. Burning mouth in a Finnish adult population. Community Dent Oral Epidemiol. 1993, 21:67-71. 10.1111\/j.1600-0528.1993.tb00723.x","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2741\/E762","article-title":"An overview of burning mouth syndrome","volume":"8","author":"Salerno C","year":"2016","unstructured":"Salerno C, Di Stasio D, Petruzzi M, et al.. An overview of burning mouth syndrome. Front Biosci (Elite Ed). 2016, 8:213-8. 10.2741\/E762","journal-title":"Front Biosci (Elite Ed)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1993.0200","article-title":"Estimated prevalence and distribution of reported orofacial pain in the United States","volume":"124","author":"Lipton JA","year":"1993","unstructured":"Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc. 1993, 124:115-21. 10.14219\/jada.archive.1993.0200","journal-title":"J Am Dent Assoc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2006.01.009","article-title":"The effect of clove and benzocaine versus placebo as topical anesthetics","volume":"34","author":"Alqareer A","year":"2006","unstructured":"Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent. 2006, 34:747-50. 10.1016\/j.jdent.2006.01.009","journal-title":"J Dent"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.JOACP_73_18","article-title":"Comparative evaluation of the efficacy of two anesthetic gels (2% lignocaine and 20% benzocaine) in reducing pain during administration of local anesthesia - A randomized controlled trial","volume":"35","author":"Nair M","year":"2019","unstructured":"Nair M, Gurunathan D. Comparative evaluation of the efficacy of two anesthetic gels (2% lignocaine and 20% benzocaine) in reducing pain during administration of local anesthesia - A randomized controlled trial. J Anaesthesiol Clin Pharmacol. 2019, 35:65-9. 10.4103\/joacp.JOACP_73_18","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_711_23","article-title":"Comparative evaluation of two different topical anesthetic agents against pain associated with intraoral injections in pediatric dental patients","volume":"16","author":"Subramanian P","year":"2024","unstructured":"Subramanian P, Kaur I, Choubey K, Arya A, Shenavi LM, Waskle R. Comparative evaluation of two different topical anesthetic agents against pain associated with intraoral injections in pediatric dental patients. J Pharm Bioallied Sci. 2024, 16:S449-51. 10.4103\/jpbs.jpbs_711_23","journal-title":"J Pharm Bioallied Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2016.16.4.237","article-title":"Recent advances in topical anesthesia","volume":"16","author":"Lee HS","year":"2016","unstructured":"Lee HS. Recent advances in topical anesthesia. J Dent Anesth Pain Med. 2016, 16:237-44. 10.17245\/jdapm.2016.16.4.237","journal-title":"J Dent Anesth Pain Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.08.007","article-title":"Effect of topical lidocaine in the oral and facial regions on tactile sensory and pain thresholds","volume":"72","author":"Okayasu I","year":"2016","unstructured":"Okayasu I, Komiyama O, Ayuse T, De Laat A. Effect of topical lidocaine in the oral and facial regions on tactile sensory and pain thresholds. Arch Oral Biol. 2016, 72:51-5. 10.1016\/j.archoralbio.2016.08.007","journal-title":"Arch Oral Biol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.10.014","article-title":"Management of neuropathic orofacial pain","volume":"103","author":"Lewis MA","year":"2007","unstructured":"Lewis MA, Sankar V, De Laat A, Benoliel R. Management of neuropathic orofacial pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007, 103:S32.e1-24. 10.1016\/j.tripleo.2006.10.014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.62.1.37","article-title":"The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine","volume":"62","author":"Strichartz GR","year":"1973","unstructured":"Strichartz GR. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol. 1973, 62:37-57. 10.1085\/jgp.62.1.37","journal-title":"J Gen Physiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.10.024","article-title":"Reliability of intraoral quantitative sensory testing (QST)","volume":"148","author":"Pigg M","year":"2010","unstructured":"Pigg M, Baad-Hansen L, Svensson P, Drangsholt M, List T. Reliability of intraoral quantitative sensory testing (QST). Pain. 2010, 148:220-6. 10.1016\/j.pain.2009.10.024","journal-title":"Pain"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2018.18.6.361","article-title":"Effect of 8% lidocaine spray on the sensory and pain thresholds of the skin of the face and hands evaluated by quantitative sensory testing","volume":"18","author":"Okayasu I","year":"2018","unstructured":"Okayasu I, Komiyama O, Ayuse T, De Laat A. Effect of 8% lidocaine spray on the sensory and pain thresholds of the skin of the face and hands evaluated by quantitative sensory testing. J Dent Anesth Pain Med. 2018, 18:361-5. 10.17245\/jdapm.2018.18.6.361","journal-title":"J Dent Anesth Pain Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5466\/ijoms.24.1","article-title":"Effects of surface anesthetics on sensory function in a tongue pain model","volume":"24","author":"Takemori M","year":"2025","unstructured":"Takemori M, Honda-Sakaki M. Effects of surface anesthetics on sensory function in a tongue pain model. IJOMS. 2025, 24:1-9. 10.5466\/ijoms.24.1","journal-title":"IJOMS"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12014","article-title":"Somatosensory profiling of intra-oral capsaicin and menthol in healthy subjects","volume":"121","author":"Lu S","year":"2013","unstructured":"Lu S, Baad-Hansen L, List T, Zhang Z, Svensson P. Somatosensory profiling of intra-oral capsaicin and menthol in healthy subjects. Eur J Oral Sci. 2013, 121:29-35. 10.1111\/eos.12014","journal-title":"Eur J Oral Sci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006-61.4.135","article-title":"A new protocol to evaluate the effect of topical anesthesia","volume":"61","author":"List T","year":"2014","unstructured":"List T, Mojir K, Svensson P, Pigg M. A new protocol to evaluate the effect of topical anesthesia. Anesth Prog. 2014, 61:135-44. 10.2344\/0003-3006-61.4.135","journal-title":"Anesth Prog"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S9492","article-title":"Topical preparations for pain relief: Efficacy and patient adherence","volume":"4","author":"Jorge LL","year":"2010","unstructured":"Jorge LL, Feres CC, Teles VE. Topical preparations for pain relief: Efficacy and patient adherence. J Pain Res. 2010, 4:11-24. 10.2147\/JPR.S9492","journal-title":"J Pain Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.06.011","article-title":"Methemoglobinemia secondary to over-the-counter Anbesol","volume":"111","author":"Orr TM","year":"2011","unstructured":"Orr TM, Orr DL 2nd. Methemoglobinemia secondary to over-the-counter Anbesol. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011, 111:e7-e11. 10.1016\/j.tripleo.2010.06.011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/670979","article-title":"An atypical case of methemoglobinemia due to self-administered benzocaine","volume":"2015","author":"Nappe TM","year":"2015","unstructured":"Nappe TM, Pacelli AM, Katz K. An atypical case of methemoglobinemia due to self-administered benzocaine. Case Rep Emerg Med. 2015, 2015:670979. 10.1155\/2015\/670979","journal-title":"Case Rep Emerg Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2344\/anpr-66-03-05","article-title":"Comparing the efficacy of a compound topical anesthetic versus benzocaine: A pilot study","volume":"67","author":"Park L","year":"2020","unstructured":"Park L, Tom J, Bui N, Wilson M, Tanbonliong T. Comparing the efficacy of a compound topical anesthetic versus benzocaine: A pilot study. Anesth Prog. 2020, 67:9-15. 10.2344\/anpr-66-03-05","journal-title":"Anesth Prog"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107375","article-title":"Micro-pharmacokinetics of lidocaine and bupivacaine transfer across a myelinated nerve fiber","volume":"165","author":"Smrkolj V","year":"2023","unstructured":"Smrkolj V, Pregeljc D, Kav\u010di\u010d H, Umek N, Mavri J. Micro-pharmacokinetics of lidocaine and bupivacaine transfer across a myelinated nerve fiber. Comput Biol Med. 2023, 165:107375. 10.1016\/j.compbiomed.2023.107375","journal-title":"Comput Biol Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/64.2.173","article-title":"Depth and duration of skin analgesia to needle insertion after topical application of EMLA cream","volume":"64","author":"Bjerring P","year":"1990","unstructured":"Bjerring P, Arendt-Nielsen L. Depth and duration of skin analgesia to needle insertion after topical application of EMLA cream. Br J Anaesth. 1990, 64:173-7. 10.1093\/bja\/64.2.173","journal-title":"Br J Anaesth"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1996.0098","article-title":"Analgesic efficacy and safety of an intraoral lidocaine patch","volume":"127","author":"Hersh EV","year":"1996","unstructured":"Hersh EV, Houpt MI, Cooper SA, Feldman RS, Wolff MS, Levin LM. Analgesic efficacy and safety of an intraoral lidocaine patch. J Am Dent Assoc. 1996, 127:1626-34. 10.14219\/jada.archive.1996.0098","journal-title":"J Am Dent Assoc"},{"key":"ref23","article-title":"Clinical effectiveness of lidocaine and benzocaine for topical anesthesia","volume":"46","author":"Rosa AL","year":"1999","unstructured":"Rosa AL, Sverzut CE, Xavier SP, Lavrador MA. Clinical effectiveness of lidocaine and benzocaine for topical anesthesia. Anesth Prog. 1999, 46:97-9.","journal-title":"Anesth Prog"},{"key":"ref24","article-title":"An analysis of the effectiveness of two topical anesthetics","volume":"37","author":"Rosivack RG","year":"1990","unstructured":"Rosivack RG, Koenigsberg SR, Maxwell KC. An analysis of the effectiveness of two topical anesthetics. Anesth Prog. 1990, 37:290-2.","journal-title":"Anesth Prog"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.02.027","article-title":"Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament","volume":"109","author":"Kim H","year":"2004","unstructured":"Kim H, Neubert JK, San Miguel A, et al.. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain. 2004, 109:488-96. 10.1016\/j.pain.2004.02.027","journal-title":"Pain"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00330-5","article-title":"Gender differences in pressure pain threshold in healthy humans","volume":"101","author":"Chesterton LS","year":"2003","unstructured":"Chesterton LS, Barlas P, Foster NE, et al.. Gender differences in pressure pain threshold in healthy humans. Pain. 2003, 101:259-266. 10.1016\/S0304-3959(02)00330-5","journal-title":"Pain"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00662.x","article-title":"Efficacy of a metered-dose 8% lidocaine pump spray for patients with post-herpetic neuralgia","volume":"10","author":"Kanai A","year":"2009","unstructured":"Kanai A, Kumaki C, Niki Y, Suzuki A, Tazawa T, Okamoto H. Efficacy of a metered-dose 8% lidocaine pump spray for patients with post-herpetic neuralgia. Pain Med. 2009, 10:902-9. 10.1111\/j.1526-4637.2009.00662.x","journal-title":"Pain Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12349","article-title":"Immediate analgesic effect of 8% lidocaine applied to the oral mucosa in patients with trigeminal neuralgia","volume":"15","author":"Niki Y","year":"2014","unstructured":"Niki Y, Kanai A, Hoshi K, Okamoto H. Immediate analgesic effect of 8% lidocaine applied to the oral mucosa in patients with trigeminal neuralgia. Pain Med. 2014, 15:826-31. 10.1111\/pme.12349","journal-title":"Pain Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02196.x","article-title":"Guidelines and recommendations for assessment of somatosensory function in oro-facial pain conditions--a taskforce report","volume":"38","author":"Svensson P","year":"2011","unstructured":"Svensson P, Baad-Hansen L, Pigg M, et al.. Guidelines and recommendations for assessment of somatosensory function in oro-facial pain conditions--a taskforce report. J Oral Rehabil. 2011, 38:366-94. 10.1111\/j.1365-2842.2010.02196.x","journal-title":"J Oral Rehabil"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419893823","article-title":"International Classification of Orofacial Pain, 1st edition (ICOP)","volume":"40","author":"Orofacial Pain Classification Committee","year":"2020","unstructured":"Orofacial Pain Classification Committee, International Headache Society. International Classification of Orofacial Pain, 1st edition (ICOP). Cephalalgia. 2020, 40:129-221. 10.1177\/0333102419893823","journal-title":"Cephalalgia"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/432127-effect-of-surface-anesthetics-on-tongue-sensory-function","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:54:43Z","timestamp":1768460083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/432127-effect-of-surface-anesthetics-on-tongue-sensory-function"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.101570","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,14]]}}}