{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:36:31Z","timestamp":1790562991712,"version":"4.1.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"DOI":"10.7759\/cureus.101574","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:50:01Z","timestamp":1768463401000},"source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Azithromycin in Preventing Pulmonary Exacerbations Among Patients With Bronchiectasis: A Systematic Review and Meta-Analysis"],"prefix":"10.7759","author":[{"given":"Renzxymon L","family":"Dela Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Adrian D","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Nicole C","family":"Bacud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minette Claire O","family":"Rosario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.160830","article-title":"Diagnosis and management of bronchiectasis","volume":"189","author":"Smith MP","year":"2017","unstructured":"Smith MP. Diagnosis and management of bronchiectasis. CMAJ. 2017, 189:E828-35. 10.1503\/cmaj.160830","journal-title":"CMAJ"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00119114","article-title":"Management of bronchiectasis in adults","volume":"45","author":"Chalmers JD","year":"2015","unstructured":"Chalmers JD, Aliberti S, Blasi F. Management of bronchiectasis in adults. Eur Respir J. 2015, 45:1446-62. 10.1183\/09031936.00119114","journal-title":"Eur Respir J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1574806","article-title":"Risk evaluation of azithromycin-induced QT prolongation in real-world practice","volume":"2018","author":"Choi Y","year":"2018","unstructured":"Choi Y, Lim HS, Chung D, Choi JG, Yoon D. Risk evaluation of azithromycin-induced QT prolongation in real-world practice. Biomed Res Int. 2018, 2018:1574806. 10.1155\/2018\/1574806","journal-title":"Biomed Res Int"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.08.2216","article-title":"Long-term azithromycin in children with bronchiectasis unrelated to cystic fibrosis: treatment effects over time","volume":"163","author":"Vicendese D","year":"2023","unstructured":"Vicendese D, Yerkovich S, Grimwood K, et al.. Long-term azithromycin in children with bronchiectasis unrelated to cystic fibrosis: treatment effects over time. Chest. 2023, 163:52-63. 10.1016\/j.chest.2022.08.2216","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00165-5","article-title":"The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial","volume":"10","author":"Stick SM","year":"2022","unstructured":"Stick SM, Foti A, Ware RS, et al.. The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial. Lancet Respir Med. 2022, 10:776-84. 10.1016\/S2213-2600(22)00165-5","journal-title":"Lancet Respir Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03778-8","article-title":"Long-term macrolide treatment for non-cystic fibrosis bronchiectasis in children: a meta-analysis","volume":"11","author":"Lee E","year":"2021","unstructured":"Lee E, Sol IS, Kim JD, et al.. Long-term macrolide treatment for non-cystic fibrosis bronchiectasis in children: a meta-analysis. Sci Rep. 2021, 11:24287. 10.1038\/s41598-021-03778-8","journal-title":"Sci Rep"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1937","article-title":"Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial","volume":"309","author":"Altenburg J","year":"2013","unstructured":"Altenburg J, de Graaff CS, Stienstra Y, et al.. Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial. JAMA. 2013, 309:1251-9. 10.1001\/jama.2013.1937","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60953-2","article-title":"Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial","volume":"380","author":"Wong C","year":"2012","unstructured":"Wong C, Jayaram L, Karalus N, et al.. Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial. Lancet. 2012, 380:660-7. 10.1016\/S0140-6736(12)60953-2","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12130","article-title":"Effects of long-term azithromycin therapy on airway oxidative stress markers in non-cystic fibrosis bronchiectasis","volume":"18","author":"Diego AD","year":"2013","unstructured":"Diego AD, Milara J, Martinez-Morag\u00f3n E, Palop M, Le\u00f3n M, Cortijo J. Effects of long-term azithromycin therapy on airway oxidative stress markers in non-cystic fibrosis bronchiectasis. Respirology. 2013, 18:1056-62. 10.1111\/resp.12130","journal-title":"Respirology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70185-1","article-title":"Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial","volume":"1","author":"Valery PC","year":"2013","unstructured":"Valery PC, Morris PS, Byrnes CA, et al.. Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2013, 1:610-20. 10.1016\/S2213-2600(13)70185-1","journal-title":"Lancet Respir Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-022-01882-y","article-title":"The efficacy of azithromycin to prevent exacerbation of non-cystic fibrosis bronchiectasis: a meta-analysis of randomized controlled studies","volume":"17","author":"Li K","year":"2022","unstructured":"Li K, Liu L, Ou Y. The efficacy of azithromycin to prevent exacerbation of non-cystic fibrosis bronchiectasis: a meta-analysis of randomized controlled studies. J Cardiothorac Surg. 2022, 17:266. 10.1186\/s13019-022-01882-y","journal-title":"J Cardiothorac Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70213-9","article-title":"The effect of long-term macrolide treatment on respiratory microbiota composition in non-cystic fibrosis bronchiectasis: an analysis from the randomised, double-blind, placebo-controlled BLESS trial","volume":"2","author":"Rogers GB","year":"2014","unstructured":"Rogers GB, Bruce KD, Martin ML, Burr LD, Serisier DJ. The effect of long-term macrolide treatment on respiratory microbiota composition in non-cystic fibrosis bronchiectasis: an analysis from the randomised, double-blind, placebo-controlled BLESS trial. Lancet Respir Med. 2014, 2:988-96. 10.1016\/S2213-2600(14)70213-9","journal-title":"Lancet Respir Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/452149-efficacy-of-azithromycin-in-preventing-pulmonary-exacerbations-among-patients-with-bronchiectasis-a-systematic-review-and-meta-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:50:01Z","timestamp":1768463401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/452149-efficacy-of-azithromycin-in-preventing-pulmonary-exacerbations-among-patients-with-bronchiectasis-a-systematic-review-and-meta-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.101574","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,14]]}}}