{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:52:12Z","timestamp":1768553532357,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,15]]},"DOI":"10.7759\/cureus.101599","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:09:11Z","timestamp":1768486151000},"source":"Crossref","is-referenced-by-count":0,"title":["PROMISE\u2011MINO: A Prospective, Open\u2011Label, Multicenter, Single\u2011Arm, Phase IV Study of the Safety, Local Tolerability, and Efficacy of Topical Minocycline Hydrochloride 4% Gel in Indian Patients With Moderate\u2011to\u2011Severe Acne Vulgaris"],"prefix":"10.7759","author":[{"given":"Vishalakshi","family":"Viswanath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swetalina","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamta","family":"Bhura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prerna","family":"Suryatale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Banguru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"De","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Sonkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Bhushan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rujuta","family":"Gadkari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhiraj","family":"Dhoot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Balasubramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiprasad","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanmant","family":"Barkate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.6862","article-title":"In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris","volume":"10","author":"Biswal I","year":"2016","unstructured":"Biswal I, Gaind R, Kumar N, et al.. In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris. J Infect Dev Ctries. 2016, 10:1140-5. 10.3855\/jidc.6862","journal-title":"J Infect Dev Ctries"},{"key":"ref2","article-title":"Pharmacokinetic comparison of once-daily topical minocycline foam 4% vs oral minocycline for moderate-to-severe acne","volume":"16","author":"Jones TM","year":"2017","unstructured":"Jones TM, Ellman H, deVries T. Pharmacokinetic comparison of once-daily topical minocycline foam 4% vs oral minocycline for moderate-to-severe acne. J Drugs Dermatol. 2017, 16:1022-8.","journal-title":"J Drugs Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.01.011","article-title":"Use of topical retinoids by dermatologists and non-dermatologists in the management of acne vulgaris","volume":"74","author":"Pena S","year":"2016","unstructured":"Pena S, Hill D, Feldman SR. Use of topical retinoids by dermatologists and non-dermatologists in the management of acne vulgaris. J Am Acad Dermatol. 2016, 74:1252-4. 10.1016\/j.jaad.2016.01.011","journal-title":"J Am Acad Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078","article-title":"Practical management of acne for clinicians: an international consensus from the Global Alliance to Improve Outcomes in Acne","volume":"78","author":"Thiboutot DM","year":"2018","unstructured":"Thiboutot DM, Dr\u00e9no B, Abanmi A, et al.. Practical management of acne for clinicians: an international consensus from the Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. 2018, 78:S1-S23.e1. 10.1016\/j.jaad.2017.09.078","journal-title":"J Am Acad Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05403.x","article-title":"Antimicrobial susceptibility of Propionibacterium acnes isolates from acne patients in Colombia","volume":"52","author":"Mendoza N","year":"2013","unstructured":"Mendoza N, Hernandez PO, Tyring SK, Haitz KA, Motta A. Antimicrobial susceptibility of Propionibacterium acnes isolates from acne patients in Colombia. Int J Dermatol. 2013, 52:688-92. 10.1111\/j.1365-4632.2011.05403.x","journal-title":"Int J Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.016","article-title":"Trends in prescribing behavior of systemic agents used in the treatment of acne among dermatologists and nondermatologists: a retrospective analysis, 2004-2013","volume":"77","author":"Barbieri JS","year":"2017","unstructured":"Barbieri JS, James WD, Margolis DJ. Trends in prescribing behavior of systemic agents used in the treatment of acne among dermatologists and nondermatologists: a retrospective analysis, 2004-2013. J Am Acad Dermatol. 2017, 77:456-63.e4. 10.1016\/j.jaad.2017.04.016","journal-title":"J Am Acad Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw586","article-title":"Increased prescribing of systemic tetracyclines and isotretinoin for treatment of acne","volume":"72","author":"Odsbu I","year":"2017","unstructured":"Odsbu I, Selmer R, St\u00e5lsby Lundborg C, Blix HS. Increased prescribing of systemic tetracyclines and isotretinoin for treatment of acne. J Antimicrob Chemother. 2017, 72:1510-5. 10.1093\/jac\/dkw586","journal-title":"J Antimicrob Chemother"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04416.x","article-title":"Large-scale worldwide observational study of adherence with acne therapy","volume":"49","author":"Dr\u00e9no B","year":"2010","unstructured":"Dr\u00e9no B, Thiboutot D, Gollnick H, et al.. Large-scale worldwide observational study of adherence with acne therapy. Int J Dermatol. 2010, 49:448-56. 10.1111\/j.1365-4632.2010.04416.x","journal-title":"Int J Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.020","article-title":"A novel topical minocycline foam for the treatment of moderate-to-severe acne vulgaris: results of 2 randomized, double-blind, phase 3 studies","volume":"80","author":"Gold LS","year":"2019","unstructured":"Gold LS, Dhawan S, Weiss J, Draelos ZD, Ellman H, Stuart IA. A novel topical minocycline foam for the treatment of moderate-to-severe acne vulgaris: results of 2 randomized, double-blind, phase 3 studies. J Am Acad Dermatol. 2019, 80:168-77. 10.1016\/j.jaad.2018.08.020","journal-title":"J Am Acad Dermatol"},{"key":"ref10","unstructured":"US Food and Drug Administration. ZILXITM (minocycline) topical foam. (2020). Accessed: September 18, 2025: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/213690s000lbl.pdf."},{"key":"ref11","article-title":"Open-label extension study evaluating long-term safety and efficacy of FMX101 4% minocycline foam for moderate-to-severe acne vulgaris","volume":"12","author":"Stein Gold L","year":"2019","unstructured":"Stein Gold L, Dhawan S, Weiss J, Draelos ZD, Ellman H, Stuart I. Open-label extension study evaluating long-term safety and efficacy of FMX101 4% minocycline foam for moderate-to-severe acne vulgaris. J Clin Aesthet Dermatol. 2019, 12:16-23.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref12","unstructured":"Central Drugs Standard Control Organisation. Recommendations of the SEC (Dermatology &amp; Allergy) made in its 11th\/24 meeting held on 13.11.2024 at CDSCO (HQ), New Delhi. (2025). Accessed: September 18, 2025: https:\/\/cdsco.gov.in\/opencms\/resources\/UploadCDSCOWeb\/2018\/UploadCommitteeFiles\/Recommendations%20Dermatology%20%20Al...."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5021\/ad.23.094","article-title":"A comprehensive review of the acne grading scale in 2023","volume":"36","author":"Bae IH","year":"2024","unstructured":"Bae IH, Kwak JH, Na CH, Kim MS, Shin BS, Choi H. A comprehensive review of the acne grading scale in 2023. Ann Dermatol. 2024, 36:65-73. 10.5021\/ad.23.094","journal-title":"Ann Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.05.078","article-title":"Efficacy and safety of a novel topical minocycline foam for the treatment of moderate to severe acne vulgaris: a phase 3 study","volume":"82","author":"Raoof TJ","year":"2020","unstructured":"Raoof TJ, Hooper D, Moore A, et al.. Efficacy and safety of a novel topical minocycline foam for the treatment of moderate to severe acne vulgaris: a phase 3 study. J Am Acad Dermatol. 2020, 82:832-7. 10.1016\/j.jaad.2019.05.078","journal-title":"J Am Acad Dermatol"},{"key":"ref15","unstructured":"SOLODYN\u00ae (minocycline HCl) extended release tablets for oral use. (2025). Accessed. September 18, 2025: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/050808s014lbl.pdf."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037","article-title":"Guidelines of care for the management of acne vulgaris","volume":"74","author":"Zaenglein AL","year":"2016","unstructured":"Zaenglein AL, Pathy AL, Schlosser BJ, et al.. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016, 74:945-73.e33. 10.1016\/j.jaad.2015.12.037","journal-title":"J Am Acad Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(98)00063-4","article-title":"Minocycline treatment and pseudotumor cerebri syndrome","volume":"126","author":"Chiu AM","year":"1998","unstructured":"Chiu AM, Chuenkongkaew WL, Cornblath WT, et al.. Minocycline treatment and pseudotumor cerebri syndrome. Am J Ophthalmol. 1998, 126:116-21. 10.1016\/s0002-9394(98)00063-4","journal-title":"Am J Ophthalmol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0063-y","article-title":"Medical adherence to acne therapy: a systematic review","volume":"15","author":"Snyder S","year":"2014","unstructured":"Snyder S, Crandell I, Davis SA, Feldman SR. Medical adherence to acne therapy: a systematic review. Am J Clin Dermatol. 2014, 15:87-94. 10.1007\/s40257-014-0063-y","journal-title":"Am J Clin Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12091455","article-title":"A prospective, randomized, comparative study of topical minocycline gel 4% with topical clindamycin phosphate gel 1% in Indian patients with acne vulgaris","volume":"12","author":"Shah B","year":"2023","unstructured":"Shah B, Mistry D, Gonsalves N, Vasani P, Dhoot D, Barkate H. A prospective, randomized, comparative study of topical minocycline gel 4% with topical clindamycin phosphate gel 1% in Indian patients with acne vulgaris. Antibiotics (Basel). 2023, 12:10.3390\/antibiotics12091455","journal-title":"Antibiotics (Basel)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/446103-promisemino-a-prospective-openlabel-multicenter-singlearm-phase-iv-study-of-the-safety-local-tolerability-and-efficacy-of-topical-minocycline-hydrochloride-4-gel-in-indian-patients-with-moderatetosevere-acne-vulgaris","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:09:15Z","timestamp":1768486155000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/446103-promisemino-a-prospective-openlabel-multicenter-singlearm-phase-iv-study-of-the-safety-local-tolerability-and-efficacy-of-topical-minocycline-hydrochloride-4-gel-in-indian-patients-with-moderatetosevere-acne-vulgaris"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.101599","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,15]]}}}