{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:32:37Z","timestamp":1768995157753,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,16]]},"DOI":"10.7759\/cureus.101679","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:12:15Z","timestamp":1768572735000},"source":"Crossref","is-referenced-by-count":0,"title":["Laboratory Aspects and Diagnostic Challenges in a Case of Hypereosinophilic Syndrome"],"prefix":"10.7759","author":[{"given":"Vanessa","family":"Rossi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Velocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Morello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.035","article-title":"Incidence of myeloproliferative hypereosinophilic syndrome in the United States and an estimate of all hypereosinophilic syndrome incidence","volume":"126","author":"Crane MM","year":"2010","unstructured":"Crane MM, Chang CM, Kobayashi MG, Weller PF. Incidence of myeloproliferative hypereosinophilic syndrome in the United States and an estimate of all hypereosinophilic syndrome incidence. J Allergy Clin Immunol. 2010, 126:179-81. 10.1016\/j.jaci.2010.03.035","journal-title":"J Allergy Clin Immunol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(87)80352-9","article-title":"Idiopathic hypereosinophilic syndrome in a 5 1\/2-month-old infant","volume":"111","author":"Wynn SR","year":"1987","unstructured":"Wynn SR, Sachs MI, Keating MU, Ostrom NK, Kadota RP, O'Connell EJ, Smithson WA. Idiopathic hypereosinophilic syndrome in a 5 1\/2-month-old infant. J Pediatr. 1987, 111:94-7. 10.1016\/s0022-3476(87)80352-9","journal-title":"J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000193467.06938.77","article-title":"Idiopathic hypereosinophilic syndrome in children: report of a 7-year-old boy with FIP1L1-PDGFRA rearrangement","volume":"27","author":"Rives S","year":"2005","unstructured":"Rives S, Alcorta I, Toll T, Tuset E, Estella J, Cross NC. Idiopathic hypereosinophilic syndrome in children: report of a 7-year-old boy with FIP1L1-PDGFRA rearrangement. J Pediatr Hematol Oncol. 2005, 27:663-5. 10.1097\/01.mph.0000193467.06938.77","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref4","article-title":"Eosinophilia detected by automated blood cell counting in ambulatory North American outpatients. Incidence and clinical significance","volume":"121","author":"Brigden M","year":"1997","unstructured":"Brigden M, Graydon C. Eosinophilia detected by automated blood cell counting in ambulatory North American outpatients. Incidence and clinical significance. Arch Pathol Lab Med. 1997, 121:963-7.","journal-title":"Arch Pathol Lab Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06038.x","article-title":"Eosinophilia: secondary, clonal and idiopathic","volume":"133","author":"Tefferi A","year":"2006","unstructured":"Tefferi A, Patnaik MM, Pardanani A. Eosinophilia: secondary, clonal and idiopathic. Br J Haematol. 2006, 133:468-92. 10.1111\/j.1365-2141.2006.06038.x","journal-title":"Br J Haematol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019","article-title":"Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes","volume":"130","author":"Valent P","year":"2012","unstructured":"Valent P, Klion AD, Horny HP, et al.. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol. 2012, 130:607-12. 10.1016\/j.jaci.2012.02.019","journal-title":"J Allergy Clin Immunol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020337","article-title":"Hematological neoplasms with eosinophilia","volume":"16","author":"Morales-Camacho RM","year":"2024","unstructured":"Morales-Camacho RM, Caballero-Velazquez T, Borrero JJ, Bernal R, Prats-Martin C. Hematological neoplasms with eosinophilia. Cancers. 2024, 16:337. 10.3390\/cancers16020337","journal-title":"Cancers"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2022000367","article-title":"Approach to the patient with suspected hypereosinophilic syndrome","volume":"2022","author":"Klion AD","year":"2022","unstructured":"Klion AD. Approach to the patient with suspected hypereosinophilic syndrome. Hematology Am Soc Hematol Educ Program. 2022, 2022:47-54. 10.1182\/hematology.2022000367","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber DA","year":"2016","unstructured":"Arber DA, Orazi A, Hasserjian R, et al.. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016, 127:2391-405. 10.1182\/blood-2016-03-643544","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.021675","article-title":"Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1","volume":"95","author":"Bain BJ","year":"2010","unstructured":"Bain BJ. Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1. Haematologica. 2010, 95:696-8. 10.3324\/haematol.2009.021675","journal-title":"Haematologica"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.04.004","article-title":"Eosinophilia in hematologic disorders","volume":"35","author":"Falchi L","year":"2015","unstructured":"Falchi L, Verstovsek S. Eosinophilia in hematologic disorders. Immunol Allergy Clin North Am. 2015, 35:439-52. 10.1016\/j.iac.2015.04.004","journal-title":"Immunol Allergy Clin North Am"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17026","article-title":"The role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm","volume":"191","author":"Goasguen JE","year":"2020","unstructured":"Goasguen JE, Bennett JM, Bain BJ, et al.. The role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm. Br J Haematol. 2020, 191:497-504. 10.1111\/bjh.17026","journal-title":"Br J Haematol"},{"key":"ref13","article-title":"Manuale di malattie del sangue","author":"De Stefano V","year":"2015","unstructured":"De Stefano V, Di Raimondo F, Nasa GL, Bosi A. Manuale di malattie del sangue. Edra, 2015."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-37","article-title":"Hypereosinophilic syndromes","volume":"2","author":"Roufosse FE","year":"2007","unstructured":"Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes. Orphanet J Rare Dis. 2007, 2:37. 10.1186\/1750-1172-2-37","journal-title":"Orphanet J Rare Dis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/030089169107700616","article-title":"A case of T-cell lymphoma accompanying marked eosinophilia, chronic eosinophilic pneumonia and eosinophilic pleural effusion. A case report","volume":"77","author":"Kawasaki A","year":"1991","unstructured":"Kawasaki A, Mizushima Y, Matsui S, Hoshino K, Yano S, Kitagawa M. A case of T-cell lymphoma accompanying marked eosinophilia, chronic eosinophilic pneumonia and eosinophilic pleural effusion. A case report. Tumori. 1991, 77:527-30. 10.1177\/030089169107700616","journal-title":"Tumori"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01697986","article-title":"Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor","volume":"71","author":"Endo M","year":"1995","unstructured":"Endo M, Usuki K, Kitazume K, Iwabe K, Okuyama Y, Urabe A. Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor. Ann Hematol. 1995, 71:313-4. 10.1007\/BF01697986","journal-title":"Ann Hematol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07174.x","article-title":"The association of eosinophilia with lymphoblastic leukaemia or lymphoma: a study of seven patients","volume":"45","author":"Catovsky D","year":"1980","unstructured":"Catovsky D, Bernasconi C, Verdonck PJ, et al.. The association of eosinophilia with lymphoblastic leukaemia or lymphoma: a study of seven patients. Br J Haematol. 1980, 45:523-34. 10.1111\/j.1365-2141.1980.tb07174.x","journal-title":"Br J Haematol"},{"key":"ref18","article-title":"World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management","volume":"89","author":"Gotlib J","year":"2014","unstructured":"Gotlib J. World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. Am J Hemat. 2014, 89:325-37. https:\/\/doi.org\/10.1002\/ajh.23664","journal-title":"Am J Hemat"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/440051-laboratory-aspects-and-diagnostic-challenges-in-a-case-of-hypereosinophilic-syndrome","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:12:16Z","timestamp":1768572736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/440051-laboratory-aspects-and-diagnostic-challenges-in-a-case-of-hypereosinophilic-syndrome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.101679","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,16]]}}}