{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:31:59Z","timestamp":1768699919801,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,17]]},"DOI":"10.7759\/cureus.101728","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T12:54:06Z","timestamp":1768654446000},"source":"Crossref","is-referenced-by-count":0,"title":["A Multifactorial Case of Acquired Hemophilia A"],"prefix":"10.7759","author":[{"given":"Jason P","family":"Willis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Kanne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.11.005","article-title":"Acquired hemophilia A: diagnosis, aetiology, clinical spectrum and treatment options","volume":"10","author":"Shetty S","year":"2011","unstructured":"Shetty S, Bhave M, Ghosh K. Acquired hemophilia A: diagnosis, aetiology, clinical spectrum and treatment options. Autoimmun Rev. 2011, 10:311-6. 10.1016\/j.autrev.2010.11.005","journal-title":"Autoimmun Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-1027-y","article-title":"Prevention and management of bleeding episodes in patients with acquired hemophilia A","volume":"78","author":"Kn\u00f6bl P","year":"2018","unstructured":"Kn\u00f6bl P. Prevention and management of bleeding episodes in patients with acquired hemophilia A. Drugs. 2018, 78:1861-72. 10.1007\/s40265-018-1027-y","journal-title":"Drugs"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2022.07.001","article-title":"Advances in acquired hemophilia A","volume":"36","author":"Poston JN","year":"2022","unstructured":"Poston JN, Kruse-Jarres R. Advances in acquired hemophilia A. Transfus Med Rev. 2022, 36:215-9. 10.1016\/j.tmrv.2022.07.001","journal-title":"Transfus Med Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.09.040","article-title":"Acquired hemophilia A: a narrative review and management approach in the emicizumab era","volume":"23","author":"Ellsworth P","year":"2025","unstructured":"Ellsworth P, Chen SL, Jones LA, Ma AD, Key NS. Acquired hemophilia A: a narrative review and management approach in the emicizumab era. J Thromb Haemost. 2025, 23:824-35. 10.1016\/j.jtha.2024.09.040","journal-title":"J Thromb Haemost"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-012-0204-5","article-title":"Rare case of acquired haemophilia and lupus anticoagulant","volume":"30","author":"Gupta D","year":"2014","unstructured":"Gupta D, Chatterjee T, Sharma A, Ganguli P, Das S, Sharma S. Rare case of acquired haemophilia and lupus anticoagulant. Indian J Hematol Blood Transfus. 2014, 30:197-200. 10.1007\/s12288-012-0204-5","journal-title":"Indian J Hematol Blood Transfus"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-023-03659-y","article-title":"Comprehensive comparison of global coagulation assays to differentiate lupus anticoagulant from acquired hemophilia A in patients with prolonged APTT","volume":"118","author":"Chikasawa Y","year":"2023","unstructured":"Chikasawa Y, Amano K, Shinozawa K, et al.. Comprehensive comparison of global coagulation assays to differentiate lupus anticoagulant from acquired hemophilia A in patients with prolonged APTT. Int J Hematol. 2023, 118:577-88. 10.1007\/s12185-023-03659-y","journal-title":"Int J Hematol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02591-4","article-title":"Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient","volume":"53","author":"Jacobs JW","year":"2022","unstructured":"Jacobs JW, Gisriel SD, Iyer K, Rinder HM. Concomitant factor VIII inhibitor and lupus anticoagulant in an asymptomatic patient. J Thromb Thrombolysis. 2022, 53:945-9. 10.1007\/s11239-021-02591-4","journal-title":"J Thromb Thrombolysis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02781.x","article-title":"False-positive results in ELISA-based anti FVIII antibody assay may occur with lupus anticoagulant and phospholipid antibodies","volume":"18","author":"Sahud M","year":"2012","unstructured":"Sahud M, Zhukov O, Mo K, Popov J, Dlott J. False-positive results in ELISA-based anti FVIII antibody assay may occur with lupus anticoagulant and phospholipid antibodies. Haemophilia. 2012, 18:777-81. 10.1111\/j.1365-2516.2012.02781.x","journal-title":"Haemophilia"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04309.x","article-title":"Management of acquired haemophilia A","volume":"9","author":"Collins PW","year":"2011","unstructured":"Collins PW. Management of acquired haemophilia A. J Thromb Haemost. 2011, 9:226-35. 10.1111\/j.1538-7836.2011.04309.x","journal-title":"J Thromb Haemost"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408930","article-title":"Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry","volume":"120","author":"Baudo F","year":"2012","unstructured":"Baudo F, Collins P, Huth-K\u00fchne A, et al.. Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry. Blood. 2012, 120:39-46. 10.1182\/blood-2012-02-408930","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022926","article-title":"Acquired hemophilia A in a woman with systemic lupus erythematosus: a case report and review of literature","volume":"99","author":"Shen P","year":"2020","unstructured":"Shen P, Li J, Tu S, Chen G, Chen C. Acquired hemophilia A in a woman with systemic lupus erythematosus: a case report and review of literature. Medicine (Baltimore). 2020, 99:e22926. 10.1097\/MD.0000000000022926","journal-title":"Medicine (Baltimore)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2024.109067","article-title":"First-line immunosuppressive therapies for acquired hemophilia A: a 25-year cohort experience and network meta-analysis","volume":"241","author":"Rungjirajittranon T","year":"2024","unstructured":"Rungjirajittranon T, Suwanawiboon B, Nakkinkun Y, et al.. First-line immunosuppressive therapies for acquired hemophilia A: a 25-year cohort experience and network meta-analysis. Thromb Res. 2024, 241:109067. 10.1016\/j.thromres.2024.109067","journal-title":"Thromb Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0993-y","article-title":"Hemarthrosis as acute presentation of acquired hemophilia in a patient with systemic lupus erythematosus: successful treatment and long-lasting remission","volume":"27","author":"Porru G","year":"2008","unstructured":"Porru G, Mura V, Piga M, et al.. Hemarthrosis as acute presentation of acquired hemophilia in a patient with systemic lupus erythematosus: successful treatment and long-lasting remission. Clin Rheumatol. 2008, 27:1581-4. 10.1007\/s10067-008-0993-y","journal-title":"Clin Rheumatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12138","article-title":"Outcome of acquired haemophilia in France: the prospective SACHA (Surveillance des Auto antiCorps au cours de l'H\u00e9mophilie Acquise) registry","volume":"19","author":"Borg JY","year":"2013","unstructured":"Borg JY, Guillet B, Le Cam-Duchez V, Goudemand J, L\u00e9vesque H. Outcome of acquired haemophilia in France: the prospective SACHA (Surveillance des Auto antiCorps au cours de l'H\u00e9mophilie Acquise) registry. Haemophilia. 2013, 19:564-70. 10.1111\/hae.12138","journal-title":"Haemophilia"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26009","article-title":"Treatment of acquired hemophilia A, a balancing act: results from a 27-year Dutch cohort study","volume":"96","author":"Schep SJ","year":"2021","unstructured":"Schep SJ, van Dijk WE, Beckers EA, et al.. Treatment of acquired hemophilia A, a balancing act: results from a 27-year Dutch cohort study. Am J Hematol. 2021, 96:51-9. 10.1002\/ajh.26009","journal-title":"Am J Hematol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-583021","article-title":"Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients","volume":"124","author":"Barcellini W","year":"2014","unstructured":"Barcellini W, Fattizzo B, Zaninoni A, et al.. Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients. Blood. 2014, 124:2930-6. 10.1182\/blood-2014-06-583021","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.05.034","article-title":"Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly","volume":"58","author":"Barcellini W","year":"2018","unstructured":"Barcellini W, Fattizzo B, Cortelezzi A. Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly. Eur J Intern Med. 2018, 58:77-83. 10.1016\/j.ejim.2018.05.034","journal-title":"Eur J Intern Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003808","article-title":"How I treat warm autoimmune hemolytic anemia","volume":"137","author":"Barcellini W","year":"2021","unstructured":"Barcellini W, Fattizzo B. How I treat warm autoimmune hemolytic anemia. Blood. 2021, 137:1283-94. 10.1182\/blood.2019003808","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1111","article-title":"Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study","volume":"70","author":"Benros ME","year":"2013","unstructured":"Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, Mortensen PB. Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry. 2013, 70:812-20. 10.1001\/jamapsychiatry.2013.1111","journal-title":"JAMA Psychiatry"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2305778120","article-title":"Social stress induces autoimmune responses against the brain","volume":"120","author":"Shimo Y","year":"2023","unstructured":"Shimo Y, Cathomas F, Lin HY, et al.. Social stress induces autoimmune responses against the brain. Proc Natl Acad Sci U S A. 2023, 120:e2305778120. 10.1073\/pnas.2305778120","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/359456-a-multifactorial-case-of-acquired-hemophilia-a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T12:54:06Z","timestamp":1768654446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/359456-a-multifactorial-case-of-acquired-hemophilia-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,17]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.101728","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,17]]}}}