{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T18:07:17Z","timestamp":1768759637234,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,17]]},"DOI":"10.7759\/cureus.101752","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:18:51Z","timestamp":1768706331000},"source":"Crossref","is-referenced-by-count":0,"title":["TRIM59 (Tripartite Motif-Containing 59) Expression in Pan-Cancer and Its Diagnostic and Prognostic Implications in Breast Cancer, Esophageal Cancer, Lung Squamous Cell Carcinoma, and Stomach Adenocarcinoma"],"prefix":"10.7759","author":[{"given":"Gamila A","family":"Attaelmanan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Y","family":"Fateh Alrhman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina N","family":"Abdelrahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarteel","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohanad","family":"Elkhidir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roaa R","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howaida","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaf","family":"Siddig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mawada","family":"Muzzammil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Alfaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Global cancer burden growing, amidst mounting need for services. (2025). Accessed. May 15, 2025: https:\/\/www.who.int\/news\/item\/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services."},{"key":"ref2","unstructured":"\u200bWorld cancer death clock. (2023). Accessed. August 7, 2023: https:\/\/www.medindia.net\/patients\/calculators\/world_cancer_clock.asp."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00322-w","article-title":"TRIM family contribute to tumorigenesis, cancer development, and drug resistance","volume":"11","author":"Huang N","year":"2022","unstructured":"Huang N, Sun X, Li P, Liu X, Zhang X, Chen Q, Xin H. TRIM family contribute to tumorigenesis, cancer development, and drug resistance. Exp Hematol Oncol. 2022, 11:75. 10.1186\/s40164-022-00322-w","journal-title":"Exp Hematol Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001410","article-title":"TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis","volume":"2","author":"Khatamianfar V","year":"2012","unstructured":"Khatamianfar V, Valiyeva F, Rennie PS, et al.. TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis. BMJ Open. 2012, 2:e001410. 10.1136\/bmjopen-2012-001410","journal-title":"BMJ Open"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29433","article-title":"TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K\/AKT\/mTOR-glycolysis signaling axis","volume":"121","author":"Li R","year":"2020","unstructured":"Li R, Weng L, Liu B, et al.. TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K\/AKT\/mTOR-glycolysis signaling axis. J Cell Biochem. 2020, 121:1986-97. 10.1002\/jcb.29433","journal-title":"J Cell Biochem"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142596","article-title":"TRIM59 promotes the proliferation and migration of non-small cell lung cancer cells by upregulating cell cycle related proteins","volume":"10","author":"Zhan W","year":"2015","unstructured":"Zhan W, Han T, Zhang C, et al.. TRIM59 promotes the proliferation and migration of non-small cell lung cancer cells by upregulating cell cycle related proteins. PLoS One. 2015, 10:e0142596. 10.1371\/journal.pone.0142596","journal-title":"PLoS One"},{"key":"ref7","article-title":"\u200bKnockdown of tripartite motif 59 (TRIM59) inhibits tumor growth in prostate cancer","volume":"20","author":"Lin WY","year":"2016","unstructured":"Lin WY, Wang H, Song X, Zhang SX, Zhou PS, Sun JM, Li JS. \u200bKnockdown of tripartite motif 59 (TRIM59) inhibits tumor growth in prostate cancer. Eur Rev Med Pharmacol Sci. 2016, 20:4864-4873.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018024","article-title":"Prognostic significance of TRIM59 for cancer patient survival: a systematic review and meta-analysis","volume":"98","author":"Wang M","year":"2019","unstructured":"Wang M, Chao C, Luo G, et al.. Prognostic significance of TRIM59 for cancer patient survival: a systematic review and meta-analysis. Medicine (Baltimore). 2019, 98:e18024. 10.1097\/MD.0000000000018024","journal-title":"Medicine (Baltimore)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2020.1756327","article-title":"Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway","volume":"40","author":"Liu G","year":"2020","unstructured":"Liu G, Song J, Zhao Y, Zhang L, Qin J, Cui Y. Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway. J Recept Signal Transduct Res. 2020, 40:471-8. 10.1080\/10799893.2020.1756327","journal-title":"J Recept Signal Transduct Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.021","article-title":"TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53","volume":"147","author":"Zhou Z","year":"2014","unstructured":"Zhou Z, Ji Z, Wang Y, Li J, Cao H, Zhu HH, Gao WQ. TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53. Gastroenterology. 2014, 147:1043-54. 10.1053\/j.gastro.2014.07.021","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22897","article-title":"TRIM59 overexpression correlates with poor prognosis and contributes to breast cancer progression through AKT signaling pathway","volume":"57","author":"Liu Y","year":"2018","unstructured":"Liu Y, Dong Y, Zhao L, Su L, Diao K, Mi X. TRIM59 overexpression correlates with poor prognosis and contributes to breast cancer progression through AKT signaling pathway. Mol Carcinog. 2018, 57:1792-802. 10.1002\/mc.22897","journal-title":"Mol Carcinog"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274823","article-title":"A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas","volume":"17","author":"Dai L","year":"2022","unstructured":"Dai L, Mugaanyi J, Zhang T, Tong J, Cai X, Lu C, Lu C. A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas. PLoS One. 2022, 17:e0274823. 10.1371\/journal.pone.0274823","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar DS","year":"2022","unstructured":"Chandrashekar DS, Karthikeyan SK, Korla PK, et al.. UALCAN: an update to the integrated cancer data analysis platform. Neoplasia. 2022, 25:18-27. 10.1016\/j.neo.2022.01.001","journal-title":"Neoplasia"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar DS","year":"2017","unstructured":"Chandrashekar DS, Bashel B, Balasubramanya SA, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BV, Varambally S. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017, 19:649-58. 10.1016\/j.neo.2017.05.002","journal-title":"Neoplasia"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa407","article-title":"TIMER2.0 for analysis of tumor-infiltrating immune cells","volume":"48","author":"Li T","year":"2020","unstructured":"Li T, Fu J, Zeng Z, et al.. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020, 48:W509-14. 10.1093\/nar\/gkaa407","journal-title":"Nucleic Acids Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li T","year":"2017","unstructured":"Li T, Fan J, Wang B, et al.. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017, 77:e108-10. 10.1158\/0008-5472.CAN-17-0307","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1028-7","article-title":"Comprehensive analyses of tumor immunity: implications for cancer immunotherapy","volume":"17","author":"Li B","year":"2016","unstructured":"Li B, Severson E, Pignon JC, et al.. Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. Genome Biol. 2016, 17:174. 10.1186\/s13059-016-1028-7","journal-title":"Genome Biol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2024.100625","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy B","year":"2024","unstructured":"Gy\u0151rffy B. Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors. Innovation (Camb). 2024, 5:100625. 10.1016\/j.xinn.2024.100625","journal-title":"Innovation (Camb)"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.596794","article-title":"Identifying breast cancer-related genes based on a novel computational framework involving KEGG pathways and PPI network modularity","volume":"12","author":"Zhang Y","year":"2021","unstructured":"Zhang Y, Xiang J, Tang L, et al.. Identifying breast cancer-related genes based on a novel computational framework involving KEGG pathways and PPI network modularity. Front Genet. 2021, 12:596794. 10.3389\/fgene.2021.596794","journal-title":"Front Genet"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bay145","article-title":"Restructured GEO: restructuring gene expression omnibus metadata for genome dynamics analysis","volume":"2019","author":"Chen G","year":"2019","unstructured":"Chen G, Ram\u00edrez JC, Deng N, Qiu X, Wu C, Zheng WJ, Wu H. Restructured GEO: restructuring gene expression omnibus metadata for genome dynamics analysis. Database (Oxford). 2019, 2019:10.1093\/database\/bay145","journal-title":"Database (Oxford)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257445","article-title":"TRIM59: a potential diagnostic and prognostic biomarker in human tumors","volume":"16","author":"Jin Z","year":"2021","unstructured":"Jin Z, Liu L, Yu Y, Li D, Zhu X, Yan D, Zhu Z. TRIM59: a potential diagnostic and prognostic biomarker in human tumors. PLoS One. 2021, 16:e0257445. 10.1371\/journal.pone.0257445","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.11199","article-title":"TRIM59 as a novel molecular biomarker to predict the prognosis of patients with NSCLC","volume":"19","author":"Lou M","year":"2020","unstructured":"Lou M, Gao Z, Zhu T, Mao X, Wang Y, Yuan K, Tong J. TRIM59 as a novel molecular biomarker to predict the prognosis of patients with NSCLC. Oncol Lett. 2020, 19:1400-8. 10.3892\/ol.2019.11199","journal-title":"Oncol Lett"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-25-0798","article-title":"Editor's note: TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3","volume":"85","author":"Sang Y","year":"2025","unstructured":"Sang Y, Li Y, Song L, et al.. Editor's note: TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3. Cancer Res. 2025, 85:1342. 10.1158\/0008-5472.CAN-25-0798","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-014-0427-5","article-title":"Biology of breast cancer in young women","volume":"16","author":"Azim HA Jr","year":"2014","unstructured":"Azim HA Jr, Partridge AH. Biology of breast cancer in young women. Breast Cancer Res. 2014, 16:427. 10.1186\/s13058-014-0427-5","journal-title":"Breast Cancer Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath S","year":"2013","unstructured":"Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013, 14:R115. 10.1186\/gb-2013-14-10-r115","journal-title":"Genome Biol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm020","article-title":"A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne women's midlife health project","volume":"13","author":"Burger HG","year":"2007","unstructured":"Burger HG, Hale GE, Robertson DM, Dennerstein L. A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne women's midlife health project. Hum Reprod Update. 2007, 13:559-65. 10.1093\/humupd\/dmm020","journal-title":"Hum Reprod Update"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.e16509","article-title":"Blockade of TRIM59 to enhance chemosensitivity of esophageal cancer cell to cisplatin by upregulating p53 expression","volume":"38","author":"Liu RF","year":"2020","unstructured":"Liu RF, Shi J, Duan X. Blockade of TRIM59 to enhance chemosensitivity of esophageal cancer cell to cisplatin by upregulating p53 expression. J Clin Oncol. 2020, 38:e16509. 10.1200\/JCO.2020.38.15_suppl.e16509","journal-title":"J Clin Oncol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3779\/j.issn.1009-3419.2020.01.04","article-title":"[Expression of TRIM59 in non-small cell lung cancer and its correlation with prognosis]","volume":"23","author":"Tian H","year":"2020","unstructured":"Tian H, Zhang D, Xu R, Qin Y, Lan Y, Jiao W, Han Y. [Expression of TRIM59 in non-small cell lung cancer and its correlation with prognosis]. Zhongguo Fei Ai Za Zhi. 2020, 23:21-8. 10.3779\/j.issn.1009-3419.2020.01.04","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203714","article-title":"Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer","volume":"13","author":"Deng Y","year":"2021","unstructured":"Deng Y, Song Z, Huang L, et al.. Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer. Aging (Albany NY). 2021, 13:24768-85. 10.18632\/aging.203714","journal-title":"Aging (Albany NY)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01688-7","article-title":"Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression","volume":"39","author":"Liang M","year":"2020","unstructured":"Liang M, Chen X, Wang L, et al.. Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression. J Exp Clin Cancer Res. 2020, 39:176. 10.1186\/s13046-020-01688-7","journal-title":"J Exp Clin Cancer Res"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/JBR.0000000000000110","article-title":"Integrated bioinformatics analysis reveals correlations of high TRIM59 expression with worse prognosis and immune infiltrates in lung adenocarcinoma","volume":"5","author":"Yang L","year":"2022","unstructured":"Yang L, Wu Y, You L, et al.. Integrated bioinformatics analysis reveals correlations of high TRIM59 expression with worse prognosis and immune infiltrates in lung adenocarcinoma. J BioX Res. 2022, 5:67-80. 10.1097\/JBR.0000000000000110","journal-title":"J BioX Res"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.11.016","article-title":"Loss of abhd5 promotes colorectal tumor development and progression by inducing aerobic glycolysis and epithelial-mesenchymal transition","volume":"9","author":"Ou J","year":"2014","unstructured":"Ou J, Miao H, Ma Y, et al.. Loss of abhd5 promotes colorectal tumor development and progression by inducing aerobic glycolysis and epithelial-mesenchymal transition. Cell Rep. 2014, 9:1798-811. 10.1016\/j.celrep.2014.11.016","journal-title":"Cell Rep"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13398-w","article-title":"Loss of ABHD5 promotes the aggressiveness of prostate cancer cells","volume":"7","author":"Chen G","year":"2017","unstructured":"Chen G, Zhou G, Aras S, et al.. Loss of ABHD5 promotes the aggressiveness of prostate cancer cells. Sci Rep. 2017, 7:13021. 10.1038\/s41598-017-13398-w","journal-title":"Sci Rep"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-0527-z","article-title":"Role of STAT3 signaling pathway in breast cancer","volume":"18","author":"Ma JH","year":"2020","unstructured":"Ma JH, Qin L, Li X. Role of STAT3 signaling pathway in breast cancer. Cell Commun Signal. 2020, 18:33. 10.1186\/s12964-020-0527-z","journal-title":"Cell Commun Signal"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.041","article-title":"TRIM59 promotes gefitinib resistance in EGFR mutant lung adenocarcinoma cells","volume":"224","author":"Cui Z","year":"2019","unstructured":"Cui Z, Liu Z, Zeng J, et al.. TRIM59 promotes gefitinib resistance in EGFR mutant lung adenocarcinoma cells. Life Sci. 2019, 224:23-32. 10.1016\/j.lfs.2019.03.041","journal-title":"Life Sci"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061517","article-title":"TRIMming down hormone-driven cancers: the biological impact of TRIM proteins on tumor development, progression and prognostication","volume":"15","author":"Pauletto E","year":"2021","unstructured":"Pauletto E, Eickhoff N, Padr\u00e3o NA, Blattner C, Zwart W. TRIMming down hormone-driven cancers: the biological impact of TRIM proteins on tumor development, progression and prognostication. Cells. 2021, 15:10. 10.3390\/cells10061517","journal-title":"Cells"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0288-3","article-title":"RIG-I-like receptors: their regulation and roles in RNA sensing","volume":"20","author":"Rehwinkel J","year":"2020","unstructured":"Rehwinkel J, Gack MU. RIG-I-like receptors: their regulation and roles in RNA sensing. Nat Rev Immunol. 2020, 20:537-51. 10.1038\/s41577-020-0288-3","journal-title":"Nat Rev Immunol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.05.028","article-title":"TRIM59 interacts with ECSIT and negatively regulates NF-\u03baB and IRF-3\/7-mediated signal pathways","volume":"422","author":"Kondo T","year":"2012","unstructured":"Kondo T, Watanabe M, Hatakeyama S. TRIM59 interacts with ECSIT and negatively regulates NF-\u03baB and IRF-3\/7-mediated signal pathways. Biochem Biophys Res Commun. 2012, 422:501-7. 10.1016\/j.bbrc.2012.05.028","journal-title":"Biochem Biophys Res Commun"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020404","article-title":"Promising targets for cancer immunotherapy: TLRs, RLRs, and STING-mediated innate immune pathways","volume":"18","author":"Li K","year":"2017","unstructured":"Li K, Qu S, Chen X, Wu Q, Shi M. Promising targets for cancer immunotherapy: TLRs, RLRs, and STING-mediated innate immune pathways. Int J Mol Sci. 2017, 18:10.3390\/ijms18020404","journal-title":"Int J Mol Sci"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.960866","article-title":"TRAT1 overexpression delays cancer progression and is associated with immune infiltration in lung adenocarcinoma","volume":"12","author":"Xiao XY","year":"2022","unstructured":"Xiao XY, Guo Q, Tong S, et al.. TRAT1 overexpression delays cancer progression and is associated with immune infiltration in lung adenocarcinoma. Front Oncol. 2022, 12:960866. 10.3389\/fonc.2022.960866","journal-title":"Front Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/388099-trim59-tripartite-motif-containing-59-expression-in-pan-cancer-and-its-diagnostic-and-prognostic-implications-in-breast-cancer-esophageal-cancer-lung-squamous-cell-carcinoma-and-stomach-adenocarcinoma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:18:57Z","timestamp":1768706337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/388099-trim59-tripartite-motif-containing-59-expression-in-pan-cancer-and-its-diagnostic-and-prognostic-implications-in-breast-cancer-esophageal-cancer-lung-squamous-cell-carcinoma-and-stomach-adenocarcinoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,17]]},"references-count":40,"URL":"https:\/\/doi.org\/10.7759\/cureus.101752","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,17]]}}}