{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:07:36Z","timestamp":1769198856768,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"DOI":"10.7759\/cureus.102158","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:17:57Z","timestamp":1769188677000},"source":"Crossref","is-referenced-by-count":0,"title":["C-reactive Protein to Albumin Ratio and Fluid Overload as Predictors of Mortality in Comparison to Pediatric Risk of Mortality (PRISM) III Score in Critically Ill Children in a Tertiary Care Hospital: A Prospective Cohort Study"],"prefix":"10.7759","author":[{"given":"Ankita","family":"Mandal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerti","family":"Swarnkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikha","family":"Malik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828a2bbd","article-title":"PELOD-2: an update of the PEdiatric Logistic Organ Dysfunction score","volume":"41","author":"Leteurtre S","year":"2013","unstructured":"Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F. PELOD-2: an update of the PEdiatric Logistic Organ Dysfunction score. Crit Care Med. 2013, 41:1761-73. 10.1097\/CCM.0b013e31828a2bbd","journal-title":"Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus WA","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985, 13:818-29.","journal-title":"Crit Care Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199605000-00004","article-title":"PRISM III: an updated Pediatric Risk of Mortality score","volume":"24","author":"Pollack MM","year":"1996","unstructured":"Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med. 1996, 24:743-52. 10.1097\/00003246-199605000-00004","journal-title":"Crit Care Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.26611\/10141931","article-title":"Study of role of serum ferritin in predicting outcome in children with severe sepsis at a tertiary hospital","volume":"19","author":"Kulkarni MS","year":"2021","unstructured":"Kulkarni MS, Shukla DA. Study of role of serum ferritin in predicting outcome in children with severe sepsis at a tertiary hospital. MedPulse Int J Pediatr. 2021, 19:48-52. 10.26611\/10141931","journal-title":"MedPulse Int J Pediatr"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9238947","article-title":"Procalcitonin value is an early prognostic factor related to mortality in admission to pediatric intensive care unit","volume":"2018","author":"Aygun F","year":"2018","unstructured":"Aygun F. Procalcitonin value is an early prognostic factor related to mortality in admission to pediatric intensive care unit. Crit Care Res Pract. 2018, 2018:9238947. 10.1155\/2018\/9238947","journal-title":"Crit Care Res Pract"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20210013","article-title":"Performance of PRISM III and PIM 2 scores in a cancer pediatric intensive care unit","volume":"33","author":"Farias EC","year":"2021","unstructured":"Farias EC, Mello ML, Assun\u00e7\u00e3o PB, Wanderley AV, Ferraro KM, Machado MM, Marinho SJ. Performance of PRISM III and PIM 2 scores in a cancer pediatric intensive care unit. Rev Bras Ter Intensiva. 2021, 33:119-24. 10.5935\/0103-507X.20210013","journal-title":"Rev Bras Ter Intensiva"},{"key":"ref7","article-title":"Physiology, albumin","author":"Moman RN","year":"2025","unstructured":"Moman RN, Gupta N, Varacallo MA. Physiology, albumin. In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2025."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-019-02934-3","article-title":"Serum Albumin and C-Reactive Protein as Predictors of Adverse Outcomes in Critically Ill Children: A Prospective Observational Pilot Study","volume":"86","author":"Bhandarkar N","year":"2019","unstructured":"Bhandarkar N, Save S, Bavdekar SB, Sisodia P, Desai S. Serum Albumin and C-Reactive Protein as Predictors of Adverse Outcomes in Critically Ill Children: A Prospective Observational Pilot Study. Indian J Pediatr. 2019, 86:758-9. 10.1007\/s12098-019-02934-3","journal-title":"Indian J Pediatr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01200","article-title":"C-reactive protein-to-albumin ratio as prognostic marker for anal squamous cell carcinoma treated with chemoradiotherapy","volume":"9","author":"Martin D","year":"2019","unstructured":"Martin D, R\u00f6del F, Balermpas P, Winkelmann R, Fokas E, R\u00f6del C. C-reactive protein-to-albumin ratio as prognostic marker for anal squamous cell carcinoma treated with chemoradiotherapy. Front Oncol. 2019, 9:1200. 10.3389\/fonc.2019.01200","journal-title":"Front Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-021-04879-1","article-title":"C-reactive protein\/albumin ratio is a prognostic indicator for predicting surgical intervention and mortality in neonates with necrotizing enterocolitis","volume":"37","author":"Mohd Amin AT","year":"2021","unstructured":"Mohd Amin AT, Zaki RA, Friedmacher F, Sharif SP. C-reactive protein\/albumin ratio is a prognostic indicator for predicting surgical intervention and mortality in neonates with necrotizing enterocolitis. Pediatr Surg Int. 2021, 37:881-6. 10.1007\/s00383-021-04879-1","journal-title":"Pediatr Surg Int"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.213","article-title":"Fluid balance and acute kidney injury","volume":"6","author":"Prowle JR","year":"2010","unstructured":"Prowle JR, Echeverri JE, Ligabo EV, Ronco C, Bellomo R. Fluid balance and acute kidney injury. Nat Rev Nephrol. 2010, 6:107-15. 10.1038\/nrneph.2009.213","journal-title":"Nat Rev Nephrol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-015-2592-7","article-title":"Early fluid overload is associated with acute kidney injury and PICU mortality in critically ill children","volume":"175","author":"Li Y","year":"2016","unstructured":"Li Y, Wang J, Bai Z, et al.. Early fluid overload is associated with acute kidney injury and PICU mortality in critically ill children. Eur J Pediatr. 2016, 175:39-48. 10.1007\/s00431-015-2592-7","journal-title":"Eur J Pediatr"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/cc6948","article-title":"Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury","volume":"12","author":"Bagshaw SM","year":"2008","unstructured":"Bagshaw SM, Brophy PD, Cruz D, Ronco C. Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury. Crit Care. 2008, 12:169. 10.1186\/cc6948","journal-title":"Crit Care"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-018-1417-y","article-title":"Association of fluid overload with mortality in critically-ill mechanically ventilated children","volume":"55","author":"Samaddar S","year":"2018","unstructured":"Samaddar S, Sankar J, Kabra SK, Lodha R. Association of fluid overload with mortality in critically-ill mechanically ventilated children. Indian Pediatr. 2018, 55:957-61. 10.1007\/s13312-018-1417-y","journal-title":"Indian Pediatr"},{"key":"ref15","article-title":"The multiple organ dysfunction syndrome","author":"Marshall JC","year":"2001","unstructured":"Marshall JC. The multiple organ dysfunction syndrome. Surgical Treatment: Evidence-Based and Problem-Oriented. Holzheimer RG, Mannick JA (ed): Zuckschwerdt, Munich; 2001."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1701623","article-title":"C-reactive protein\/albumin ratio as an independent predictor of mortality in critically ill pediatric patients","volume":"10","author":"Mohamed SA","year":"2020","unstructured":"Mohamed SA, ElHawary R. C-reactive protein\/albumin ratio as an independent predictor of mortality in critically ill pediatric patients. J Child Sci. 2020, 10:1-11. 10.1055\/s-0040-1701623","journal-title":"J Child Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1590\/s1807-59322010001100005","article-title":"Application of the pediatric risk of mortality (PRISM) score and determination of mortality risk factors in a tertiary pediatric intensive care unit","volume":"65","author":"Costa GA","year":"2010","unstructured":"Costa GA, Delgado AF, Ferraro A, Okay TS. Application of the pediatric risk of mortality (PRISM) score and determination of mortality risk factors in a tertiary pediatric intensive care unit. Clinics (Sao Paulo). 2010, 65:1087-92. 10.1590\/s1807-59322010001100005","journal-title":"Clinics (Sao Paulo)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2020.02.011","article-title":"Outcomes and prognostic factors for pediatric cancer patients admitted to an intensive care unit in a university hospital","volume":"62","author":"Dursun A","year":"2020","unstructured":"Dursun A, \u00d6zsoylu S, Aky\u0131ld\u0131z BN. Outcomes and prognostic factors for pediatric cancer patients admitted to an intensive care unit in a university hospital. Turk J Pediatr. 2020, 62:252-8. 10.24953\/turkjped.2020.02.011","journal-title":"Turk J Pediatr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/children10111731","article-title":"Predictive value of PRISM-4, PIM-3, CRP, albumin, CRP\/albumin ratio and lactate in critically ill children","volume":"10","author":"Arslan G","year":"2023","unstructured":"Arslan G, Besci T, \u00d6zdemir G, et al.. Predictive value of PRISM-4, PIM-3, CRP, albumin, CRP\/albumin ratio and lactate in critically ill children. Children (Basel). 2023, 10:10.3390\/children10111731","journal-title":"Children (Basel)"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2231-3","article-title":"Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy","volume":"37","author":"Selewski DT","year":"2011","unstructured":"Selewski DT, Cornell TT, Lombel RM, et al.. Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy. Intensive Care Med. 2011, 37:1166-73. 10.1007\/s00134-011-2231-3","journal-title":"Intensive Care Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31825bc54d","article-title":"Fluid balance in critically ill children with acute lung injury","volume":"40","author":"Valentine SL","year":"2012","unstructured":"Valentine SL, Sapru A, Higgerson RA, et al.. Fluid balance in critically ill children with acute lung injury. Crit Care Med. 2012, 40:2883-9. 10.1097\/CCM.0b013e31825bc54d","journal-title":"Crit Care Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02949-w","article-title":"Association between early fluid overload and mortality in critically-ill mechanically ventilated children: a single-center retrospective cohort study","volume":"21","author":"Kong X","year":"2021","unstructured":"Kong X, Zhu Y, Zhu X. Association between early fluid overload and mortality in critically-ill mechanically ventilated children: a single-center retrospective cohort study. BMC Pediatr. 2021, 21:474. 10.1186\/s12887-021-02949-w","journal-title":"BMC Pediatr"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00306","article-title":"Fluid overload in critically ill children","volume":"6","author":"Raina R","year":"2018","unstructured":"Raina R, Sethi SK, Wadhwani N, Vemuganti M, Krishnappa V, Bansal SB. Fluid overload in critically ill children. Front Pediatr. 2018, 6:306. 10.3389\/fped.2018.00306","journal-title":"Front Pediatr"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102714","article-title":"Fluid accumulation in critically ill children: a systematic review and meta-analysis","volume":"74","author":"Lintz VC","year":"2024","unstructured":"Lintz VC, Vieira RA, Carioca FL, et al.. Fluid accumulation in critically ill children: a systematic review and meta-analysis. EClinicalMedicine. 2024, 74:102714. 10.1016\/j.eclinm.2024.102714","journal-title":"EClinicalMedicine"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4274\/cayd.galenos.2025.59354","article-title":"Association between early fluid overload and mortality in critically ill children","volume":"26","author":"Wibisono MA","year":"2025","unstructured":"Wibisono MA, Saragih RA, Pasaribu AP, Lubis SM, Wijaya H, Harahap J. Association between early fluid overload and mortality in critically ill children. J Pediatr Emerg Intensive Care Med. 2025, 26:68-73. 10.4274\/cayd.galenos.2025.59354","journal-title":"J Pediatr Emerg Intensive Care Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-021-04070-3","article-title":"Fluid overload in critically ill children: more questions than answers!","volume":"89","author":"Dhochak N","year":"2022","unstructured":"Dhochak N, Lodha R. Fluid overload in critically ill children: more questions than answers!. Indian J Pediatr. 2022, 89:218-9. 10.1007\/s12098-021-04070-3","journal-title":"Indian J Pediatr"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/jpcc.jpcc_31_24","article-title":"Fluid overload in critically ill children: A narrative review","volume":"11","author":"Charaya S","year":"2024","unstructured":"Charaya S, Angurana SK . Fluid overload in critically ill children: A narrative review. J Pediatr Crit Care. 2024, 11:118-26. 10.4103\/jpcc.jpcc_31_24","journal-title":"J Pediatr Crit Care"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/402954-c-reactive-protein-to-albumin-ratio-and-fluid-overload-as-predictors-of-mortality-in-comparison-to-pediatric-risk-of-mortality-prism-iii-score-in-critically-ill-children-in-a-tertiary-care-hospital-a-prospective-cohort-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:17:58Z","timestamp":1769188678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/402954-c-reactive-protein-to-albumin-ratio-and-fluid-overload-as-predictors-of-mortality-in-comparison-to-pediatric-risk-of-mortality-prism-iii-score-in-critically-ill-children-in-a-tertiary-care-hospital-a-prospective-cohort-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.102158","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,23]]}}}