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Durability of new restorative materials in Class III cavities. J Adhes Dent. 2001, 3:65-70.","journal-title":"J Adhes Dent"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1994.tb01588.x","article-title":"Assessment of states of dentures and interest in implant-retained prosthetic treatment in 55-year-old edentulous Finns","volume":"22","author":"Salonen MA","year":"1994","unstructured":"Salonen MA. Assessment of states of dentures and interest in implant-retained prosthetic treatment in 55-year-old edentulous Finns. Community Dent Oral Epidemiol. 1994, 22:130-5. 10.1111\/j.1600-0528.1994.tb01588.x","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref50","article-title":"Clinical assessment of two years of a fluoride-containing amalgam","volume":"42","author":"Valenzuela AV","year":"1994","unstructured":"Valenzuela AV, Cifuentes SG, Cort\u00e9s PM, Vega GF. Clinical assessment of two years of a fluoride-containing amalgam. Odontol Chil. 1994, 42:5-8.","journal-title":"Odontol Chil"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(93)90006-c","article-title":"Five-year study of Class II restorations in permanent teeth using amalgam, glass polyalkenoate (ionomer) cerment and resin-based composite materials","volume":"21","author":"Mj\u00f6r IA","year":"1993","unstructured":"Mj\u00f6r IA, Jokstad A. Five-year study of Class II restorations in permanent teeth using amalgam, glass polyalkenoate (ionomer) cerment and resin-based composite materials. J Dent. 1993, 21:338-43. 10.1016\/0300-5712(93)90006-c","journal-title":"J Dent"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1159\/000261459","article-title":"Class II amalgam restorations, glass-ionomer tunnel restorations, and caries development on adjacent tooth surfaces: a 3-year clinical study","volume":"26","author":"Svanberg M","year":"1992","unstructured":"Svanberg M. Class II amalgam restorations, glass-ionomer tunnel restorations, and caries development on adjacent tooth surfaces: a 3-year clinical study. Caries Res. 1992, 26:315-8. 10.1159\/000261459","journal-title":"Caries Res"},{"key":"ref53","article-title":"Clinical comparison of Class V resin composite and glass ionomer restorations","volume":"5","author":"Powell LV","year":"1992","unstructured":"Powell LV, Gordon GE, Johnson GH. Clinical comparison of Class V resin composite and glass ionomer restorations. Am J Dent. 1992, 5:249-52.","journal-title":"Am J Dent"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2025.105912","article-title":"Two-year randomized clinical trial to evaluate the performance of posterior bulk-fill resin composite with ionic releasing restorative material","volume":"160","author":"Raghip AG","year":"2025","unstructured":"Raghip AG, Comisi JC, Hamama HH, Mahmoud SH. Two-year randomized clinical trial to evaluate the performance of posterior bulk-fill resin composite with ionic releasing restorative material. J Dent. 2025, 160:105912. 10.1016\/j.jdent.2025.105912","journal-title":"J Dent"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.4103\/jioh.jioh_299_24","article-title":"Clinical performance of bioactive bulk-fill composite vs. high viscosity glass ionomer in head and neck radiotherapy patients: a randomized controlled trial","volume":"17","author":"Ebrahim NA","year":"2025","unstructured":"Ebrahim NA, El-Kady DM, El-Zoghby AF. Clinical performance of bioactive bulk-fill composite vs. high viscosity glass ionomer in head and neck radiotherapy patients: a randomized controlled trial. J Int Oral Health. 2025, 17:283-92. 10.4103\/jioh.jioh_299_24","journal-title":"J Int Oral Health"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.21608\/adjc.2023.169905.1179","article-title":"Clinical evaluation of new bioactive restorative material versus high viscosity glass hybrid reinforced glass ionomer in restoration of proximal lesions: a randomized clinical trial","volume":"6","author":"Kamal RA","year":"2024","unstructured":"Kamal RA, Hassan RR, Shaalan OO. Clinical evaluation of new bioactive restorative material versus high viscosity glass hybrid reinforced glass ionomer in restoration of proximal lesions: a randomized clinical trial. 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