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Epilepsia. 2013, 54:5-8. 10.1111\/epi.12175","journal-title":"Epilepsia"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7597-13.5.232","article-title":"Managing common complex symptomatic epilepsies: tumors and trauma: American Epilepsy Society-2012 annual course summary","volume":"13","author":"Burneo JG","year":"2013","unstructured":"Burneo JG, Sirven JI, Kiesel LW, et al.. Managing common complex symptomatic epilepsies: tumors and trauma: American Epilepsy Society-2012 annual course summary. Epilepsy Curr. 2013, 13:232-5. 10.5698\/1535-7597-13.5.232","journal-title":"Epilepsy Curr"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.69","article-title":"Epilepsy: responsive neurostimulation-modulating the epileptic brain","volume":"10","author":"Ben-Menachem E","year":"2014","unstructured":"Ben-Menachem E, Krauss GL. Epilepsy: responsive neurostimulation-modulating the epileptic brain. Nat Rev Neurol. 2014, 10:247-8. 10.1038\/nrneurol.2014.69","journal-title":"Nat Rev Neurol"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a393d1","article-title":"Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology","volume":"81","author":"Morris GL 3rd","year":"2013","unstructured":"Morris GL 3rd, Gloss D, Buchhalter J, Mack KJ, Nickels K, Harden C. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013, 81:1453-9. 10.1212\/WNL.0b013e3182a393d1","journal-title":"Neurology"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165979","article-title":"Physical exercise and seizure activity","volume":"1867","author":"Arida RM","year":"2021","unstructured":"Arida RM. Physical exercise and seizure activity. Biochim Biophys Acta-Mol Basis Dis. 2021, 1867:165979. 10.1016\/j.bbadis.2020.165979","journal-title":"Biochim Biophys Acta-Mol Basis Dis"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01118.x","article-title":"Does physical exercise influence the occurrence of epileptiform EEG discharges in children?","volume":"38","author":"Nakken KO","year":"1997","unstructured":"Nakken KO, L\u00f8yning A, L\u00f8yning T, Gl\u00f8ersen G, Larsson PG. Does physical exercise influence the occurrence of epileptiform EEG discharges in children?. Epilepsia. 1997, 38:279-84. 10.1111\/j.1528-1157.1997.tb01118.x","journal-title":"Epilepsia"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1177\/1550059420949768","article-title":"The yield of ambulatory EEG-video monitoring","volume":"52","author":"Primiani CT","year":"2021","unstructured":"Primiani CT, Rivera-Cruz A, Trudeau P, Sullivan L, MacIver S, Benbadis SR. The yield of ambulatory EEG-video monitoring. Clin EEG Neurosci. 2021, 52:274-9. 10.1177\/1550059420949768","journal-title":"Clin EEG Neurosci"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2021.3052811","article-title":"EEG-based brain-computer interfaces (BCIs): a survey of recent studies on signal sensing technologies and computational intelligence approaches and their applications","volume":"18","author":"Gu X","year":"2021","unstructured":"Gu X, Cao Z, Jolfaei A, Xu P, Wu D, Jung TP, Lin CT. EEG-based brain-computer interfaces (BCIs): a survey of recent studies on signal sensing technologies and computational intelligence approaches and their applications. 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