{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:14:11Z","timestamp":1769678051912,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,28]]},"DOI":"10.7759\/cureus.102506","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:03:18Z","timestamp":1769634198000},"source":"Crossref","is-referenced-by-count":0,"title":["Aquagenic Wrinkling of the Palms as a Screening Indicator for Cystic Fibrosis Beyond Infancy"],"prefix":"10.7759","author":[{"given":"Alexios","family":"Alexopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Ntokos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Briana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louiza","family":"Kontara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgos","family":"Chouliaras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kanaka-Gantenbein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Stefanaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamprini","family":"Nasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01708.x","article-title":"High prevalence of aquagenic wrinkling of the palms in patients with cystic fibrosis and association with measurable increases in transepidermal water loss","volume":"29","author":"Arkin LM","year":"2012","unstructured":"Arkin LM, Flory JH, Shin DB, et al.. High prevalence of aquagenic wrinkling of the palms in patients with cystic fibrosis and association with measurable increases in transepidermal water loss. Pediatr Dermatol. 2012, 29:560-6. 10.1111\/j.1525-1470.2011.01708.x","journal-title":"Pediatr Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.260","article-title":"Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls and genotype-phenotype correlations","volume":"145","author":"Berk DR","year":"2009","unstructured":"Berk DR, Ciliberto HM, Sweet SC, Ferkol TW, Bayliss SJ. Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls and genotype-phenotype correlations. Arch Dermatol. 2009, 145:1296-9. 10.1001\/archdermatol.2009.260","journal-title":"Arch Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.04.002","article-title":"Aquagenic wrinkling in children under two years of age: could this be a potential clinical referral tool for cystic fibrosis among non-screened populations?","volume":"20","author":"Paul GR","year":"2021","unstructured":"Paul GR, Bai S, Jackson K, McCoy KS. Aquagenic wrinkling in children under two years of age: could this be a potential clinical referral tool for cystic fibrosis among non-screened populations?. J Cyst Fibros. 2021, 20:e77-83. 10.1016\/j.jcf.2021.04.002","journal-title":"J Cyst Fibros"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80087-9","article-title":"Transient reactive papulotranslucent acrokeratoderma","volume":"34","author":"English JC 3rd","year":"1996","unstructured":"English JC 3rd, McCollough ML. Transient reactive papulotranslucent acrokeratoderma. J Am Acad Dermatol. 1996, 34:686-7. 10.1016\/S0190-9622(96)80087-9","journal-title":"J Am Acad Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114586","article-title":"Aquagenic syringeal acrokeratoderma: report of two teenage cases","volume":"45","author":"MacCormack MA","year":"2001","unstructured":"MacCormack MA, Wiss K, Malhotra R. Aquagenic syringeal acrokeratoderma: report of two teenage cases. J Am Acad Dermatol. 2001, 45:124-6. 10.1067\/mjd.2001.114586","journal-title":"J Am Acad Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00799.x","article-title":"Aquagenic keratoderma","volume":"17","author":"Betlloch I","year":"2003","unstructured":"Betlloch I, Vergara G, Albares MP, Pascual JC, Silvestre JF, Botella R. Aquagenic keratoderma. J Eur Acad Dermatol Venereol. 2003, 17:306-7. 10.1046\/j.1468-3083.2003.00799.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21224.x","article-title":"Idiopathic aquagenic wrinkling of the palms","volume":"21","author":"Davis LS","year":"2004","unstructured":"Davis LS, Woody CM. Idiopathic aquagenic wrinkling of the palms. Pediatr Dermatol. 2004, 21:180. 10.1111\/j.0736-8046.2004.21224.x","journal-title":"Pediatr Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2007.00412.x","article-title":"Aquagenic wrinkling of the palms in a cystic fibrosis carrier","volume":"49","author":"Gild R","year":"2008","unstructured":"Gild R, Clay CD. Aquagenic wrinkling of the palms in a cystic fibrosis carrier. Australas J Dermatol. 2008, 49:19-20. 10.1111\/j.1440-0960.2007.00412.x","journal-title":"Australas J Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm1103833","article-title":"Aquagenic wrinkling of palms in cystic fibrosis","volume":"366","author":"Weibel L","year":"2012","unstructured":"Weibel L, Spinas R. Aquagenic wrinkling of palms in cystic fibrosis. N Engl J Med. 2012, 366:e32. 10.1056\/NEJMicm1103833","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09914.x","article-title":"Aquagenic wrinkling of the palms in cystic fibrosis and the cystic fibrosis carrier state: a case-control study","volume":"163","author":"Gild R","year":"2010","unstructured":"Gild R, Clay CD, Morey S. Aquagenic wrinkling of the palms in cystic fibrosis and the cystic fibrosis carrier state: a case-control study. Br J Dermatol. 2010, 163:1082-4. 10.1111\/j.1365-2133.2010.09914.x","journal-title":"Br J Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00620.x","article-title":"Cutaneous manifestations of cystic fibrosis","volume":"25","author":"Bernstein ML","year":"2008","unstructured":"Bernstein ML, McCusker MM, Grant-Kels JM. Cutaneous manifestations of cystic fibrosis. Pediatr Dermatol. 2008, 25:150-7. 10.1111\/j.1525-1470.2008.00620.x","journal-title":"Pediatr Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012588099","article-title":"Functional requirement of aquaporin-5 in plasma membranes of sweat glands","volume":"99","author":"Nejsum LN","year":"2002","unstructured":"Nejsum LN, Kwon TH, Jensen UB, et al.. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc Natl Acad Sci U S A. 2002, 99:511-6. 10.1073\/pnas.012588099","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017322","article-title":"Evidence for reduced Cl\u2212 and increased Na+ permeability in cystic fibrosis human primary cell cultures","volume":"405","author":"Boucher RC","year":"1988","unstructured":"Boucher RC, Cotton CU, Gatzy JT, Knowles MR, Yankaskas JR. Evidence for reduced Cl\u2212 and increased Na+ permeability in cystic fibrosis human primary cell cultures. J Physiol. 1988, 405:77-103. 10.1113\/jphysiol.1988.sp017322","journal-title":"J Physiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.5.621","article-title":"Aquagenic wrinkling of the palms in patients with cystic fibrosis homozygous for the \u0394F508 CFTR mutation","volume":"141","author":"Katz KA","year":"2005","unstructured":"Katz KA, Yan AC, Turner ML. Aquagenic wrinkling of the palms in patients with cystic fibrosis homozygous for the \u0394F508 CFTR mutation. Arch Dermatol. 2005, 141:621-4. 10.1001\/archderm.141.5.621","journal-title":"Arch Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-019-1481-y","article-title":"Aquagenic wrinkling of skin: a screening test for cystic fibrosis","volume":"56","author":"Singh A","year":"2019","unstructured":"Singh A, Lodha R, Shastri S, Sethuraman G, Sreedevi KN, Kabra M, Kabra SK. Aquagenic wrinkling of skin: a screening test for cystic fibrosis. Indian Pediatr. 2019, 56:109-13. 10.1007\/s13312-019-1481-y","journal-title":"Indian Pediatr"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000319754","article-title":"Aquagenic wrinkling of the palms in an adult cystic fibrosis population","volume":"221","author":"Tolland JP","year":"2010","unstructured":"Tolland JP, Boyle J, Hall V, McKenna KE, Elborn JS. Aquagenic wrinkling of the palms in an adult cystic fibrosis population. Dermatology. 2010, 221:326-30. 10.1159\/000319754","journal-title":"Dermatology"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09764.x","article-title":"Frequency of aquagenic palmoplantar keratoderma in cystic fibrosis: a new sign of cystic fibrosis?","volume":"163","author":"Gar\u00e7on-Michel N","year":"2010","unstructured":"Gar\u00e7on-Michel N, Roguedas-Contios AM, Rault G, et al.. Frequency of aquagenic palmoplantar keratoderma in cystic fibrosis: a new sign of cystic fibrosis?. Br J Dermatol. 2010, 163:162-6. 10.1111\/j.1365-2133.2010.09764.x","journal-title":"Br J Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17312","article-title":"Aquagenic wrinkling of the palms after brief immersion to water test as a screening tool for cystic fibrosis diagnosis","volume":"35","author":"Alexopoulos A","year":"2021","unstructured":"Alexopoulos A, Chouliaras G, Kakourou T, et al.. Aquagenic wrinkling of the palms after brief immersion to water test as a screening tool for cystic fibrosis diagnosis. J Eur Acad Dermatol Venereol. 2021, 35:1717-24. 10.1111\/jdv.17312","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19308","article-title":"Aquagenic wrinkling of the palms in a cohort of Greek children diagnosed with cystic fibrosis: associated clinical parameters","volume":"37","author":"Alexopoulos A","year":"2023","unstructured":"Alexopoulos A, Chouliaras G, Kakourou T, et al.. Aquagenic wrinkling of the palms in a cohort of Greek children diagnosed with cystic fibrosis: associated clinical parameters. J Eur Acad Dermatol Venereol. 2023, 37:2362-9. 10.1111\/jdv.19308","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2025.03.096","article-title":"Aquagenic wrinkling of the palms in cystic fibrosis patients treated with cystic fibrosis transmembrane conductance regulator modulators","volume":"24","author":"Hrvoi\u0107 L","year":"2025","unstructured":"Hrvoi\u0107 L, Bambir I, Todori\u0107 I, et al.. Aquagenic wrinkling of the palms in cystic fibrosis patients treated with cystic fibrosis transmembrane conductance regulator modulators. J Cyst Fibros. 2025, 24:S90. 10.1016\/j.jcf.2025.03.096","journal-title":"J Cyst Fibros"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2023.4519","article-title":"Aquagenic wrinkling of the palms in a teenager with cystic fibrosis during the COVID-19 pandemic","volume":"33","author":"Cardoso AL","year":"2023","unstructured":"Cardoso AL, Barbosa T. Aquagenic wrinkling of the palms in a teenager with cystic fibrosis during the COVID-19 pandemic. Eur J Dermatol. 2023, 33:436-7. 10.1684\/ejd.2023.4519","journal-title":"Eur J Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.20344\/amp.21948","article-title":"Aquagenic wrinkling of the palms in a patient with cystic fibrosis","volume":"38","author":"Apar\u00edcio Martins I","year":"2025","unstructured":"Apar\u00edcio Martins I, Santos-Coelho M, Fernandes C. Aquagenic wrinkling of the palms in a patient with cystic fibrosis. Acta Med Port. 2025, 38:117-8. 10.20344\/amp.21948","journal-title":"Acta Med Port"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-025-05428-7","article-title":"Aquagenic wrinkling of the palms\u2014a good early screening tool for cystic fibrosis (CF) in malnourished young infants in resource limited setting","volume":"92","author":"Manoh J","year":"2025","unstructured":"Manoh J, Kumar M, Mathai S, Varkki S. Aquagenic wrinkling of the palms\u2014a good early screening tool for cystic fibrosis (CF) in malnourished young infants in resource limited setting. Indian J Pediatr. 2025, 92:422. 10.1007\/s12098-025-05428-7","journal-title":"Indian J Pediatr"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ijns11020024","article-title":"Cystic fibrosis newborn screening: a systematic review-driven consensus guideline from the United States Cystic Fibrosis Foundation","volume":"11","author":"McGarry ME","year":"2025","unstructured":"McGarry ME, Raraigh KS, Farrell P, et al.. Cystic fibrosis newborn screening: a systematic review-driven consensus guideline from the United States Cystic Fibrosis Foundation. Int J Neonatal Screen. 2025, 11:24. 10.3390\/ijns11020024","journal-title":"Int J Neonatal Screen"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2019.02.003","article-title":"Newborn screening for cystic fibrosis: is there benefit for everyone?","volume":"31","author":"Course CW","year":"2019","unstructured":"Course CW, Hanks R. Newborn screening for cystic fibrosis: is there benefit for everyone?. Paediatr Respir Rev. 2019, 31:3-5. 10.1016\/j.prrv.2019.02.003","journal-title":"Paediatr Respir Rev"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15323","article-title":"Aquagenic wrinkling of the palms: review of the literature","volume":"47","author":"Yang K","year":"2022","unstructured":"Yang K, Zhou C, Luke J. Aquagenic wrinkling of the palms: review of the literature. Clin Exp Dermatol. 2022, 47:1910-5. 10.1111\/ced.15323","journal-title":"Clin Exp Dermatol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2024.01.005","article-title":"Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues","volume":"23","author":"Burgel PR","year":"2024","unstructured":"Burgel PR, Southern KW, Addy C, et al.. Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues. J Cyst Fibros. 2024, 23:187-202. 10.1016\/j.jcf.2024.01.005","journal-title":"J Cyst Fibros"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/448735-aquagenic-wrinkling-of-the-palms-as-a-screening-indicator-for-cystic-fibrosis-beyond-infancy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:03:19Z","timestamp":1769634199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/448735-aquagenic-wrinkling-of-the-palms-as-a-screening-indicator-for-cystic-fibrosis-beyond-infancy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.102506","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,28]]}}}