{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T22:22:19Z","timestamp":1769898139160,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,31]]},"DOI":"10.7759\/cureus.102684","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:44:25Z","timestamp":1769852665000},"source":"Crossref","is-referenced-by-count":0,"title":["Zinc Deficiency Among Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.7759","author":[{"given":"Rahman Hameed","family":"Mohammed Abdul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafisa","family":"Reyaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abebe","family":"Yigzaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal Asad","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helai","family":"Hussaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Qasim","family":"Rauf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelum","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng SC","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, et al.. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017, 390:2769-78. 10.1016\/S0140-6736(17)32448-0","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan GG","year":"2015","unstructured":"Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015, 12:720-7. 10.1038\/nrgastro.2015.150","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor B","year":"2011","unstructured":"Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011, 474:307-17. 10.1038\/nature10209","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.12.027","article-title":"ESPEN guideline: clinical nutrition in inflammatory bowel disease","volume":"36","author":"Forbes A","year":"2017","unstructured":"Forbes A, Escher J, H\u00e9buterne X, et al.. ESPEN guideline: clinical nutrition in inflammatory bowel disease. Clin Nutr. 2017, 36:321-47. 10.1016\/j.clnu.2016.12.027","journal-title":"Clin Nutr"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2119\/2008-00033.Prasad","article-title":"Zinc in human health: effect of zinc on immune cells","volume":"14","author":"Prasad AS","year":"2008","unstructured":"Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008, 14:353-7. 10.2119\/2008-00033.Prasad","journal-title":"Mol Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1360S","article-title":"Zinc homeostasis in humans","volume":"130","author":"King JC","year":"2000","unstructured":"King JC, Shames DM, Woodhouse LR. Zinc homeostasis in humans. J Nutr. 2000, 130:1360S-6S. 10.1093\/jn\/130.5.1360S","journal-title":"J Nutr"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i4.496","article-title":"Zinc and gastrointestinal disease","volume":"5","author":"Skrovanek S","year":"2014","unstructured":"Skrovanek S, DiGuilio K, Bailey R, et al.. Zinc and gastrointestinal disease. World J Gastrointest Pathophysiol. 2014, 5:496-513. 10.4291\/wjgp.v5.i4.496","journal-title":"World J Gastrointest Pathophysiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200105000-00003","article-title":"Zinc supplementation tightens \"leaky gut\" in Crohn's disease","volume":"7","author":"Sturniolo GC","year":"2001","unstructured":"Sturniolo GC, Di Leo V, Ferronato A, D'Odorico A, D'Inc\u00e0 R. Zinc supplementation tightens \"leaky gut\" in Crohn's disease. Inflamm Bowel Dis. 2001, 7:94-8. 10.1097\/00054725-200105000-00003","journal-title":"Inflamm Bowel Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27230G","article-title":"Methods of assessment of zinc status in humans: a systematic review","volume":"89","author":"Lowe NM","year":"2009","unstructured":"Lowe NM, Fekete K, Decsi T. Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr. 2009, 89:2040S-51S. 10.3945\/ajcn.2009.27230G","journal-title":"Am J Clin Nutr"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601049","article-title":"Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls","volume":"54","author":"Geerling BJ","year":"2000","unstructured":"Geerling BJ, Badart-Smook A, Stockbr\u00fcgger RW, Brummer RJ. Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr. 2000, 54:514-21. 10.1038\/sj.ejcn.1601049","journal-title":"Eur J Clin Nutr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0148607107031004311","article-title":"Nutrition assessment of patients with inflammatory bowel disease","volume":"31","author":"Vagianos K","year":"2007","unstructured":"Vagianos K, Bector S, McConnell J, Bernstein CN. Nutrition assessment of patients with inflammatory bowel disease. JPEN J Parenter Enteral Nutr. 2007, 31:311-9. 10.1177\/0148607107031004311","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000989","article-title":"Zinc deficiency is associated with poor clinical outcomes in patients with inflammatory bowel disease","volume":"23","author":"Siva S","year":"2017","unstructured":"Siva S, Rubin DT, Gulotta G, Wroblewski K, Pekow J. Zinc deficiency is associated with poor clinical outcomes in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2017, 23:152-7. 10.1097\/MIB.0000000000000989","journal-title":"Inflamm Bowel Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000206541.15963.c3","article-title":"Nutritional deficiencies in patients with Crohn's disease in remission","volume":"12","author":"Filippi J","year":"2006","unstructured":"Filippi J, Al-Jaouni R, Wiroth JB, H\u00e9buterne X, Schneider SM. Nutritional deficiencies in patients with Crohn's disease in remission. Inflamm Bowel Dis. 2006, 12:185-91. 10.1097\/01.MIB.0000206541.15963.c3","journal-title":"Inflamm Bowel Dis"},{"key":"ref14","article-title":"The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease","volume":"48","author":"Ojuawo A","year":"2002","unstructured":"Ojuawo A, Keith L. The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease. Cent Afr J Med. 2002, 48:116-9.","journal-title":"Cent Afr J Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref16","unstructured":"Ottawa Hospital Research Institute. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. (2025). Accessed: 2026: https:\/\/ohri.ca\/en\/who-we-are\/core-facilities-and-platforms\/ottawa-methods-centre\/newcastle-ottawa-scale."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu17213378","article-title":"Prevalence and impact of zinc deficiency on clinical outcomes in inflammatory bowel disease","volume":"17","author":"Almuhaya H","year":"2025","unstructured":"Almuhaya H, Alsalamah R, Sallam A, et al.. Prevalence and impact of zinc deficiency on clinical outcomes in inflammatory bowel disease. Nutrients. 2025, 17:3378. 10.3390\/nu17213378","journal-title":"Nutrients"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16333","article-title":"Risk factors for vitamin D, zinc, and selenium deficiencies in Korean patients with inflammatory bowel disease","volume":"11","author":"Han YM","year":"2017","unstructured":"Han YM, Yoon H, Lim S, et al.. Risk factors for vitamin D, zinc, and selenium deficiencies in Korean patients with inflammatory bowel disease. Gut Liver. 2017, 11:363-9. 10.5009\/gnl16333","journal-title":"Gut Liver"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.05.010","article-title":"A prospective analysis of micronutrient status in quiescent inflammatory bowel disease","volume":"40","author":"MacMaster MJ","year":"2021","unstructured":"MacMaster MJ, Damianopoulou S, Thomson C, et al.. A prospective analysis of micronutrient status in quiescent inflammatory bowel disease. Clin Nutr. 2021, 40:327-31. 10.1016\/j.clnu.2020.05.010","journal-title":"Clin Nutr"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2020.00124","article-title":"Effectiveness of administering zinc acetate hydrate to patients with inflammatory bowel disease and zinc deficiency: a retrospective observational two-center study","volume":"20","author":"Sakurai K","year":"2022","unstructured":"Sakurai K, Furukawa S, Katsurada T, et al.. Effectiveness of administering zinc acetate hydrate to patients with inflammatory bowel disease and zinc deficiency: a retrospective observational two-center study. Intest Res. 2022, 20:78-89. 10.5217\/ir.2020.00124","journal-title":"Intest Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otaa001","article-title":"The copper\/zinc ratio correlates with markers of disease activity in patients with inflammatory bowel disease","volume":"2","author":"Schneider T","year":"2020","unstructured":"Schneider T, Caviezel D, Ayata CK, Kiss C, Niess JH, Hruz P. The copper\/zinc ratio correlates with markers of disease activity in patients with inflammatory bowel disease. Crohns Colitis 360. 2020, 2:otaa001. 10.1093\/crocol\/otaa001","journal-title":"Crohns Colitis 360"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.26574\/maedica.2020.16.1.29","article-title":"The prevalence of zinc deficiency in Crohn\u2019s disease patients","volume":"16","author":"Soltani Z","year":"2021","unstructured":"Soltani Z, Rafiei F, EBi A, Rafiei R. The prevalence of zinc deficiency in Crohn\u2019s disease patients. Maedica (Bucur). 2021, 16:29-33. 10.26574\/maedica.2020.16.1.29","journal-title":"Maedica (Bucur)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194052","article-title":"Prevalence of zinc deficiency in inflammatory bowel disease: a systematic review and meta-analysis","volume":"14","author":"Zupo R","year":"2022","unstructured":"Zupo R, Sila A, Castellana F, et al.. Prevalence of zinc deficiency in inflammatory bowel disease: a systematic review and meta-analysis. Nutrients. 2022, 14:4052. 10.3390\/nu14194052","journal-title":"Nutrients"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1649658","article-title":"Roles of zinc and zinc transporters in development, progression, and treatment of inflammatory bowel disease (IBD)","volume":"12","author":"Mitchell SB","year":"2025","unstructured":"Mitchell SB, Aydemir TB. Roles of zinc and zinc transporters in development, progression, and treatment of inflammatory bowel disease (IBD). Front Nutr. 2025, 12:1649658. 10.3389\/fnut.2025.1649658","journal-title":"Front Nutr"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.5.387","article-title":"Zinc absorption in Crohn's disease","volume":"21","author":"Sturniolo GC","year":"1980","unstructured":"Sturniolo GC, Molokhia MM, Shields R, Turnberg LA. Zinc absorption in Crohn's disease. Gut. 1980, 21:387-91. 10.1136\/gut.21.5.387","journal-title":"Gut"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000132851.50841.D7","article-title":"Zinc metabolism in adolescents with Crohn's disease","volume":"56","author":"Griffin IJ","year":"2004","unstructured":"Griffin IJ, Kim SC, Hicks PD, Liang LK, Abrams SA. Zinc metabolism in adolescents with Crohn's disease. Pediatr Res. 2004, 56:235-9. 10.1203\/01.PDR.0000132851.50841.D7","journal-title":"Pediatr Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s I","year":"2012","unstructured":"Ord\u00e1s I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012, 380:1606-19. 10.1016\/S0140-6736(12)60150-0","journal-title":"Lancet"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070900","article-title":"The impact of zinc and zinc homeostasis on the intestinal mucosal barrier and intestinal diseases","volume":"12","author":"Wan Y","year":"2022","unstructured":"Wan Y, Zhang B. The impact of zinc and zinc homeostasis on the intestinal mucosal barrier and intestinal diseases. Biomolecules. 2022, 12:900. 10.3390\/biom12070900","journal-title":"Biomolecules"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1813047","article-title":"New insights into the role of trace elements in IBD","volume":"2018","author":"G\u00eelc\u0103-Blanariu GE","year":"2018","unstructured":"G\u00eelc\u0103-Blanariu GE, Diaconescu S, Ciocoiu M, \u0218tef\u0103nescu G. New insights into the role of trace elements in IBD. Biomed Res Int. 2018, 2018:1813047. 10.1155\/2018\/1813047","journal-title":"Biomed Res Int"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1143123","article-title":"Adjunctive therapeutic effects of micronutrient supplementation in inflammatory bowel disease","volume":"14","author":"Wu Y","year":"2023","unstructured":"Wu Y, Liu C, Dong W. Adjunctive therapeutic effects of micronutrient supplementation in inflammatory bowel disease. Front Immunol. 2023, 14:1143123. 10.3389\/fimmu.2023.1143123","journal-title":"Front Immunol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.2.225","article-title":"Zinc toxicity","volume":"51","author":"Fosmire GJ","year":"1990","unstructured":"Fosmire GJ. Zinc toxicity. Am J Clin Nutr. 1990, 51:225-7. 10.1093\/ajcn\/51.2.225","journal-title":"Am J Clin Nutr"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/448461-zinc-deficiency-among-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:44:26Z","timestamp":1769852666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/448461-zinc-deficiency-among-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":31,"URL":"https:\/\/doi.org\/10.7759\/cureus.102684","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,31]]}}}