{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T04:16:43Z","timestamp":1770092203362,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"DOI":"10.7759\/cureus.102833","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:30:46Z","timestamp":1770046246000},"source":"Crossref","is-referenced-by-count":0,"title":["Severe Persistent Neonatal Immune Thrombocytopenia Despite Optimized Maternal Chronic Immune Thrombocytopenia (ITP) Management"],"prefix":"10.7759","author":[{"given":"Nick","family":"Trevino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Kuffour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adora","family":"Okogbule-Wonodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Wentworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mekdem","family":"Bisrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inez","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.568","article-title":"Evidence-based management of immune thrombocytopenia: ASH guideline update","volume":"2018","author":"Neunert CE","year":"2018","unstructured":"Neunert CE, Cooper N. Evidence-based management of immune thrombocytopenia: ASH guideline update. Hematology Am Soc Hematol Educ Program. 2018, 2018:568-75. 10.1182\/asheducation-2018.1.568","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003100","article-title":"ACOG practice bulletin no. 207: thrombocytopenia in pregnancy","volume":"133","author":"American College of Obstetricians and Gynecologists","year":"2019","unstructured":"American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 207: thrombocytopenia in pregnancy. Obstet Gynecol. 2019, 133:e181-93. 10.1097\/AOG.0000000000003100","journal-title":"Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14697","article-title":"Severe primary autoimmune thrombocytopenia in pregnancy: a national cohort study","volume":"125","author":"Care A","year":"2018","unstructured":"Care A, Pavord S, Knight M, Alfirevic Z. Severe primary autoimmune thrombocytopenia in pregnancy: a national cohort study. BJOG. 2018, 125:604-12. 10.1111\/1471-0528.14697","journal-title":"BJOG"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-781971","article-title":"Thrombocytopenia in pregnancy","volume":"130","author":"Cines DB","year":"2017","unstructured":"Cines DB, Levine LD. Thrombocytopenia in pregnancy. Blood. 2017, 130:2271-77. 10.1182\/blood-2017-05-781971","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812","article-title":"Updated international consensus report on the investigation and management of primary immune thrombocytopenia","volume":"3","author":"Provan D","year":"2019","unstructured":"Provan D, Arnold DM, Bussel JB, et al.. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019, 3:3780-817. 10.1182\/bloodadvances.2019000812","journal-title":"Blood Adv"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14419","article-title":"The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta-analysis of a diagnostic test","volume":"17","author":"Vrbensky JR","year":"2019","unstructured":"Vrbensky JR, Moore JE, Arnold DM, Smith JW, Kelton JG, Nazy I. The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta-analysis of a diagnostic test. J Thromb Haemost. 2019, 17:787-94. 10.1111\/jth.14419","journal-title":"J Thromb Haemost"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/neo.23-7-e462","article-title":"Immune-mediated neonatal thrombocytopenia","volume":"23","author":"Batton E","year":"2022","unstructured":"Batton E, Leibel SL. Immune-mediated neonatal thrombocytopenia. Neoreviews. 2022, 23:e462-71. 10.1542\/neo.23-7-e462","journal-title":"Neoreviews"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2022.100988","article-title":"Risk of intracranial hemorrhage in neonates with maternal immune thrombocytopenia: a meta-analysis","volume":"56","author":"Gonzalez-Porras JR","year":"2022","unstructured":"Gonzalez-Porras JR, Palomino D, Vaquero-Roncero LM, et al.. Risk of intracranial hemorrhage in neonates with maternal immune thrombocytopenia: a meta-analysis. Blood Rev. 2022, 56:100988. 10.1016\/j.blre.2022.100988","journal-title":"Blood Rev"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-2017.x","article-title":"Recurrence of neonatal thrombocytopenia due to maternal autoimmune thrombocytopenia","volume":"96","author":"Christiaens GC","year":"1997","unstructured":"Christiaens GC, Nieuwenhuis HK, von dem Borne AE, et al.. Recurrence of neonatal thrombocytopenia due to maternal autoimmune thrombocytopenia. Br J Haematol. 1997, 96:171-175. 10.1046\/j.1365-2141.1997.d01-2017.x","journal-title":"Br J Haematol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12036","article-title":"Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura","volume":"105","author":"van der Lugt NM","year":"2013","unstructured":"van der Lugt NM, van Kampen A, Walther FJ, Brand A, Lopriore E. Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura. Vox Sang. 2013, 105:236-43. 10.1111\/vox.12036","journal-title":"Vox Sang"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2214617","article-title":"Management of primary immune thrombocytopenia in pregnancy","volume":"389","author":"Bussel JB","year":"2023","unstructured":"Bussel JB, Hou M, Cines DB. Management of primary immune thrombocytopenia in pregnancy. N Engl J Med. 2023, 389:540-8. 10.1056\/NEJMra2214617","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(00)90106-9","article-title":"Management of idiopathic thrombocytopenic purpura in pregnancy","volume":"37","author":"Gill KK","year":"2000","unstructured":"Gill KK, Kelton JG. Management of idiopathic thrombocytopenic purpura in pregnancy. Semin Hematol. 2000, 37:275-89. 10.1016\/S0037-1963(00)90106-9","journal-title":"Semin Hematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-020-01390-w","article-title":"Maternal and fetal outcomes of pregnancy in patients with immune thrombocytopenia","volume":"71","author":"Kashyap R","year":"2021","unstructured":"Kashyap R, Garg A, Pradhan M. Maternal and fetal outcomes of pregnancy in patients with immune thrombocytopenia. J Obstet Gynaecol India. 2021, 71:124-30. 10.1007\/s13224-020-01390-w","journal-title":"J Obstet Gynaecol India"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16252","article-title":"Risk factors for severe neonatal thrombocytopenia in cases of maternal immune thrombocytopenia","volume":"111","author":"Point F","year":"2022","unstructured":"Point F, Terriou L, Rakza T, et al.. Risk factors for severe neonatal thrombocytopenia in cases of maternal immune thrombocytopenia. Acta Paediatr. 2022, 111:985-91. 10.1111\/apa.16252","journal-title":"Acta Paediatr"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1562-6","article-title":"Factors predictive of neonatal thrombocytopenia in pregnant women with immune thrombocytopenia","volume":"99","author":"Kawaguchi K","year":"2014","unstructured":"Kawaguchi K, Matsubara K, Takafuta T, et al.. Factors predictive of neonatal thrombocytopenia in pregnant women with immune thrombocytopenia. Int J Hematol. 2014, 99:570-6. 10.1007\/s12185-014-1562-6","journal-title":"Int J Hematol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5546\/aap.2021.eng.e202","article-title":"Neonatal thrombocytopenia: a review. I. Definitions, differential diagnosis, causes, immune thrombocytopenia","volume":"119","author":"Donato H","year":"2021","unstructured":"Donato H. Neonatal thrombocytopenia: a review. I. Definitions, differential diagnosis, causes, immune thrombocytopenia. Arch Argent Pediatr. 2021, 119:e202-14. 10.5546\/aap.2021.eng.e202","journal-title":"Arch Argent Pediatr"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000365135","article-title":"Evidence-based advances in transfusion practice in neonatal intensive care units","volume":"106","author":"Christensen RD","year":"2014","unstructured":"Christensen RD, Carroll PD, Josephson CD. Evidence-based advances in transfusion practice in neonatal intensive care units. Neonatology. 2014, 106:245-53. 10.1159\/000365135","journal-title":"Neonatology"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2021.06.003","article-title":"Neonatal platelet transfusions: starting again","volume":"35","author":"Moore CM","year":"2021","unstructured":"Moore CM, Curley AE. Neonatal platelet transfusions: starting again. Transfus Med Rev. 2021, 35:29-35. 10.1016\/j.tmrv.2021.06.003","journal-title":"Transfus Med Rev"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-614446","article-title":"Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers","volume":"126","author":"Hauschner H","year":"2015","unstructured":"Hauschner H, Rosenberg N, Seligsohn U, et al.. Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers. Blood. 2015, 126:661-4. 10.1182\/blood-2014-12-614446","journal-title":"Blood"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/450237-severe-persistent-neonatal-immune-thrombocytopenia-despite-optimized-maternal-chronic-immune-thrombocytopenia-itp-management","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:30:47Z","timestamp":1770046247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/450237-severe-persistent-neonatal-immune-thrombocytopenia-despite-optimized-maternal-chronic-immune-thrombocytopenia-itp-management"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.102833","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}