{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:55:50Z","timestamp":1778277350920,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"DOI":"10.7759\/cureus.102884","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T11:59:06Z","timestamp":1770119946000},"source":"Crossref","is-referenced-by-count":1,"title":["Underrecognized Thrombotic Risk in Klinefelter Syndrome: A Clinical Insight"],"prefix":"10.7759","author":[{"given":"Hrithik Dakssesh","family":"Putta Nagarajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed  Afsharhussain","family":"Hithayathulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejashvi","family":"Rameshkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Ramij","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitish","family":"Thirugnanasambandam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-016-0541-6","article-title":"Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism","volume":"40","author":"Bonomi M","year":"2017","unstructured":"Bonomi M, Rochira V, Pasquali D, Balercia G, Jannini EA, Ferlin A. Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism. J Endocrinol Invest. 2017, 40:123-34. 10.1007\/s40618-016-0541-6","journal-title":"J Endocrinol Invest"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2016.04.020","article-title":"Advances in the interdisciplinary care of children with Klinefelter syndrome","volume":"63","author":"Davis S","year":"2016","unstructured":"Davis S, Howell S, Wilson R, Tanda T, Ross J, Zeitler P, Tartaglia N. Advances in the interdisciplinary care of children with Klinefelter syndrome. Adv Pediatr. 2016, 63:15-46. 10.1016\/j.yapd.2016.04.020","journal-title":"Adv Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study","volume":"88","author":"Bojesen A","year":"2003","unstructured":"Bojesen A, Juul S, Gravholt CH. Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. J Clin Endocrinol Metab. 2003, 88:622-6. 10.1210\/jc.2002-021491","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/tre.945","article-title":"Venous thromboembolism in Klinefelter syndrome: a clot in the knowledge?","volume":"14","author":"Birch S","year":"2023","unstructured":"Birch S. Venous thromboembolism in Klinefelter syndrome: a clot in the knowledge?. Trend Urol Men Health. 2023, 14:23-6. 10.1002\/tre.945","journal-title":"Trend Urol Men Health"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-02-0141","article-title":"Classic thrombophilic gene variants","volume":"114","author":"Mannucci PM","year":"2015","unstructured":"Mannucci PM, Franchini M. Classic thrombophilic gene variants. Thromb Haemost. 2015, 114:885-9. 10.1160\/TH15-02-0141","journal-title":"Thromb Haemost"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.01117.x","article-title":"Increased activity of factor VIII coagulant associated with venous ulcer in a patient with Klinefelter's syndrome","volume":"19","author":"Dissemond J","year":"2005","unstructured":"Dissemond J, Knab J, Lehnen M, Goos M. Increased activity of factor VIII coagulant associated with venous ulcer in a patient with Klinefelter's syndrome. J Eur Acad Dermatol Venereol. 2005, 19:240-2. 10.1111\/j.1468-3083.2004.01117.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/1557988318801158","article-title":"The effect of PAI-1 gene variants and PAI-1 plasma levels on development of thrombophilia in patients with Klinefelter syndrome","volume":"12","author":"Erkal B","year":"2018","unstructured":"Erkal B, Kalayci Yigin A, Palanduz S, Dasdemir S, Seven M. The effect of PAI-1 gene variants and PAI-1 plasma levels on development of thrombophilia in patients with Klinefelter syndrome. Am J Mens Health. 2018, 12:2152-6. 10.1177\/1557988318801158","journal-title":"Am J Mens Health"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2014.03.007","article-title":"New approaches to the Klinefelter syndrome","volume":"75","author":"Nieschlag E","year":"2014","unstructured":"Nieschlag E, Werler S, Wistuba J, Zitzmann M. New approaches to the Klinefelter syndrome. Ann Endocrinol (Paris). 2014, 75:88-97. 10.1016\/j.ando.2014.03.007","journal-title":"Ann Endocrinol (Paris)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1076029607304750","article-title":"Severe arterial thrombophilia associated with a homozygous MTHFR gene mutation (A1298C) in a young man with Klinefelter syndrome","volume":"14","author":"Ozbek M","year":"2008","unstructured":"Ozbek M, Ozt\u00fcrk MA, Ureten K, Ceneli O, Erdogan M, Haznedaroglu IC. Severe arterial thrombophilia associated with a homozygous MTHFR gene mutation (A1298C) in a young man with Klinefelter syndrome. Clin Appl Thromb Hemost. 2008, 14:369-71. 10.1177\/1076029607304750","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/mbc.0b013e32833894eb","article-title":"Recurrent deep vein thrombosis and pulmonary embolism in a young man with Klinefelter's syndrome and heterozygous mutation of MTHFR-677C>T and 1298A>C","volume":"21","author":"Angel JR","year":"2010","unstructured":"Angel JR, Parker S, Sells RE, Atallah E. Recurrent deep vein thrombosis and pulmonary embolism in a young man with Klinefelter's syndrome and heterozygous mutation of MTHFR-677C&gt;T and 1298A&gt;C. Blood Coagul Fibrinolysis. 2010, 21:372-5. 10.1097\/mbc.0b013e32833894eb","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200301000-00017","article-title":"Severe venous thromboembolism in a young man with Klinefelter's syndrome and heterozygosis for both G20210A prothrombin and factor V Leiden mutations","volume":"14","author":"Lapecorella M","year":"2003","unstructured":"Lapecorella M, Marino R, De Pergola G, Scaraggi FA, Speciale V, De Mitrio V. Severe venous thromboembolism in a young man with Klinefelter's syndrome and heterozygosis for both G20210A prothrombin and factor V Leiden mutations. Blood Coagul Fibrinolysis. 2003, 14:95-8. 10.1097\/00001721-200301000-00017","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.1985","article-title":"Serious venous thromboembolism, heterozygous factor V Leiden and prothrombin G20210A mutations in a patient with Klinefelter syndrome and type 2 diabetes","volume":"48","author":"Ayli M","year":"2009","unstructured":"Ayli M, Ertek S. Serious venous thromboembolism, heterozygous factor V Leiden and prothrombin G20210A mutations in a patient with Klinefelter syndrome and type 2 diabetes. Intern Med. 2009, 48:1681-5. 10.2169\/internalmedicine.48.1985","journal-title":"Intern Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/455815-underrecognized-thrombotic-risk-in-klinefelter-syndrome-a-clinical-insight","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T11:59:06Z","timestamp":1770119946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/455815-underrecognized-thrombotic-risk-in-klinefelter-syndrome-a-clinical-insight"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.102884","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}