{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:14:20Z","timestamp":1770232460320,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"DOI":"10.7759\/cureus.102931","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:41:14Z","timestamp":1770187274000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparing Cardiovascular Morbidity and Mortality in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy Versus Sustained Low-Efficiency Dialysis: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Kirshan","family":"Lal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loveleen K","family":"Johal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fnu","family":"Iram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Khan","family":"Nasrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeevkumar N","family":"Palvia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera Fatima","family":"Syeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Raza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inam","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rejep","family":"Aliyev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahan","family":"Nepesova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.015","article-title":"Cardiovascular impact in patients undergoing maintenance hemodialysis: clinical management considerations","volume":"232","author":"Chirakarnjanakorn S","year":"2017","unstructured":"Chirakarnjanakorn S, Navaneethan SD, Francis GS, Tang WH. Cardiovascular impact in patients undergoing maintenance hemodialysis: clinical management considerations. Int J Cardiol. 2017, 232:12-23. 10.1016\/j.ijcard.2017.01.015","journal-title":"Int J Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092364","article-title":"Cardiovascular consequences of acute kidney injury: treatment options","volume":"11","author":"Voicehovska JG","year":"2023","unstructured":"Voicehovska JG, Trumpika D, Voicehovskis VV, et al.. Cardiovascular consequences of acute kidney injury: treatment options. Biomedicines. 2023, 11:2364. 10.3390\/biomedicines11092364","journal-title":"Biomedicines"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.08.031","article-title":"Dialysis-induced cardiovascular and multiorgan morbidity","volume":"5","author":"Canaud B","year":"2020","unstructured":"Canaud B, Kooman JP, Selby NM, et al.. Dialysis-induced cardiovascular and multiorgan morbidity. Kidney Int Rep. 2020, 5:1856-69. 10.1016\/j.ekir.2020.08.031","journal-title":"Kidney Int Rep"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4274\/cayd.galenos.2023.71677","article-title":"Continuous renal replacement therapy (CRRT) protocol in critically ill children","volume":"11","author":"K\u00f6ker A","year":"2024","unstructured":"K\u00f6ker A, Yaman A, Akkuzu E, et al.. Continuous renal replacement therapy (CRRT) protocol in critically ill children. J Pediatr Emerg Intensive Care Med. 2024, 11:29-56. 10.4274\/cayd.galenos.2023.71677","journal-title":"J Pediatr Emerg Intensive Care Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/ph17121571","article-title":"CRRT is more than just continuous renal replacement therapy","volume":"17","author":"Erd\u00e9lyi L","year":"2024","unstructured":"Erd\u00e9lyi L, Tr\u00e1sy D. CRRT is more than just continuous renal replacement therapy. Pharmaceuticals (Basel). 2024, 17:1571. 10.3390\/ph17121571","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2580065","article-title":"Sustained low-efficiency dialysis-an old method but possibly a new solution for environmental nephrology","volume":"47","author":"Rymarz A","year":"2025","unstructured":"Rymarz A, Wantoch-Rekowski F, \u017bebrowski P, Jakubowska Z, K\u0119pska-Dzili\u0144ska M, Wojtaszek E, Ma\u0142yszko J. Sustained low-efficiency dialysis-an old method but possibly a new solution for environmental nephrology. Ren Fail. 2025, 47:2580065. 10.1080\/0886022X.2025.2580065","journal-title":"Ren Fail"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl627","article-title":"Sustained low-efficiency dialysis (SLED) with prostacyclin in critically ill patients with acute renal failure","volume":"22","author":"Fiaccadori E","year":"2007","unstructured":"Fiaccadori E, Maggiore U, Parenti E, et al.. Sustained low-efficiency dialysis (SLED) with prostacyclin in critically ill patients with acute renal failure. Nephrol Dial Transplant. 2007, 22:529-37. 10.1093\/ndt\/gfl627","journal-title":"Nephrol Dial Transplant"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-025-01517-0","article-title":"Renal replacement therapy in an intensive care unit: guidelines from the SRLF-GFRUP consensus conference","volume":"15","author":"Jourdain M","year":"2025","unstructured":"Jourdain M, Chatti IG, Housni B, et al.. Renal replacement therapy in an intensive care unit: guidelines from the SRLF-GFRUP consensus conference. Ann Intensive Care. 2025, 15:100. 10.1186\/s13613-025-01517-0","journal-title":"Ann Intensive Care"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/1524839919893361","article-title":"A review of the PubMed PICO tool: using evidence-based practice in health education","volume":"21","author":"Brown D","year":"2020","unstructured":"Brown D. A review of the PubMed PICO tool: using evidence-based practice in health education. Health Promot Pract. 2020, 21:496-8. 10.1177\/1524839919893361","journal-title":"Health Promot Pract"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2663-7","article-title":"The SOFA score-development, utility and challenges of accurate assessment in clinical trials","volume":"23","author":"Lambden S","year":"2019","unstructured":"Lambden S, Laterre PF, Levy MM, Francois B. The SOFA score-development, utility and challenges of accurate assessment in clinical trials. Crit Care. 2019, 23:374. 10.1186\/s13054-019-2663-7","journal-title":"Crit Care"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang A","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010, 25:603-5. 10.1007\/s10654-010-9491-z","journal-title":"Eur J Epidemiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne JA","year":"2016","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, et al.. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016, 355:i4919. 10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.32114\/cci.2025.8.2.21.33","article-title":"Comparison of sustained low-efficiency dialysis and continuous renal replacement therapy in patients in the intensive care unit with acute kidney injury: a search for a safe and rapid therapeutic approach","volume":"8","author":"Garre S","year":"2025","unstructured":"Garre S, Kuragayala SD, Mudigonda S. Comparison of sustained low-efficiency dialysis and continuous renal replacement therapy in patients in the intensive care unit with acute kidney injury: a search for a safe and rapid therapeutic approach. Crit Care Innov. 2025, 8:21-33. 10.32114\/cci.2025.8.2.21.33","journal-title":"Crit Care Innov"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.88678","article-title":"A comparative nonrandomised observational study of different modalities of renal replacement therapy (continuous renal replacement therapy vs. sustained low efficiency dialysis) with acute kidney injury in an intensive care unit setup: a pilot study","volume":"17","author":"Dash CS","year":"2025","unstructured":"Dash CS, Harbada R, Deshpande RV, Khan Pathan A. A comparative nonrandomised observational study of different modalities of renal replacement therapy (continuous renal replacement therapy vs. sustained low efficiency dialysis) with acute kidney injury in an intensive care unit setup: a pilot study. Cureus. 2025, 17:e88678. 10.7759\/cureus.88678","journal-title":"Cureus"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s43162-024-00357-x","article-title":"Hemodynamic tolerability and efficacy of hemodialysis modalities in critically ill patients","volume":"36","author":"Bandi VK","year":"2024","unstructured":"Bandi VK, Shekar M, Elumalai R, Matcha J. Hemodynamic tolerability and efficacy of hemodialysis modalities in critically ill patients. Egypt J Intern Med. 2024, 36:88. 10.1186\/s43162-024-00357-x","journal-title":"Egypt J Intern Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0123-4","article-title":"Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study","volume":"16","author":"Kitchlu A","year":"2015","unstructured":"Kitchlu A, Adhikari N, Burns KE, et al.. Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study. BMC Nephrol. 2015, 16:127. 10.1186\/s12882-015-0123-4","journal-title":"BMC Nephrol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/cc11445","article-title":"Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts","volume":"16","author":"Schwenger V","year":"2012","unstructured":"Schwenger V, Weigand MA, Hoffmann O, et al.. Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts. Crit Care. 2012, 16:R140. 10.1186\/cc11445","journal-title":"Crit Care"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3171\/2013.4.JNS122102","article-title":"The hemodynamic effects during sustained low-efficiency dialysis versus continuous veno-venous hemofiltration for uremic patients with brain hemorrhage: a crossover study","volume":"119","author":"Wu VC","year":"2013","unstructured":"Wu VC, Huang TM, Shiao CC, et al.. The hemodynamic effects during sustained low-efficiency dialysis versus continuous veno-venous hemofiltration for uremic patients with brain hemorrhage: a crossover study. J Neurosurg. 2013, 119:1288-95. 10.3171\/2013.4.JNS122102","journal-title":"J Neurosurg"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/cc14727","article-title":"Challenges and pitfalls when implementing renal replacement therapy in the ICU","volume":"19","author":"Mehta RL","year":"2015","unstructured":"Mehta RL. Challenges and pitfalls when implementing renal replacement therapy in the ICU. Crit Care. 2015, 19:S9. 10.1186\/cc14727","journal-title":"Crit Care"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028118","article-title":"Sustained low efficiency dialysis is non-inferior to continuous renal replacement therapy in critically ill patients with acute kidney injury: a comparative meta-analysis","volume":"100","author":"Dalbhi SA","year":"2021","unstructured":"Dalbhi SA, Alorf R, Alotaibi M, et al.. Sustained low efficiency dialysis is non-inferior to continuous renal replacement therapy in critically ill patients with acute kidney injury: a comparative meta-analysis. Medicine (Baltimore). 2021, 100:e28118. 10.1097\/MD.0000000000028118","journal-title":"Medicine (Baltimore)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2478\/rjim-2023-0033","article-title":"Comparison of outcomes of different modalities of renal replacement therapy in patients of acute kidney injury: a single centre prospective observational study","volume":"62","author":"Aggarwal HK","year":"2024","unstructured":"Aggarwal HK, Jain D, Agarwal A, Dahiya S, Misra P, Saha A. Comparison of outcomes of different modalities of renal replacement therapy in patients of acute kidney injury: a single centre prospective observational study. Rom J Intern Med. 2024, 62:138-49. 10.2478\/rjim-2023-0033","journal-title":"Rom J Intern Med"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-65782-y","article-title":"The association between the change in severity score from baseline and the outcomes of critically ill patients was enhanced by integration of bioimpedance analysis parameters","volume":"14","author":"Hu Z","year":"2024","unstructured":"Hu Z, Li C, Zhu S, Ge Y, Gong D. The association between the change in severity score from baseline and the outcomes of critically ill patients was enhanced by integration of bioimpedance analysis parameters. Sci Rep. 2024, 14:14681. 10.1038\/s41598-024-65782-y","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-24629","article-title":"Is SLED efficient in sepsis-associated acute kidney injury: hope but hold!","volume":"28","author":"Chhallani AA","year":"2024","unstructured":"Chhallani AA. Is SLED efficient in sepsis-associated acute kidney injury: hope but hold!. Indian J Crit Care Med. 2024, 28:5-7. 10.5005\/jp-journals-10071-24629","journal-title":"Indian J Crit Care Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4103\/ijccm.IJCCM_85_17","article-title":"A pilot randomized controlled trial of comparison between extended daily hemodialysis and continuous veno-venous hemodialysis in patients of acute kidney injury with septic shock","volume":"21","author":"Mishra SB","year":"2017","unstructured":"Mishra SB, Azim A, Prasad N, Singh RK, Poddar B, Gurjar M, Baronia AK. A pilot randomized controlled trial of comparison between extended daily hemodialysis and continuous veno-venous hemodialysis in patients of acute kidney injury with septic shock. Indian J Crit Care Med. 2017, 21:262-7. 10.4103\/ijccm.IJCCM_85_17","journal-title":"Indian J Crit Care Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/444882-comparing-cardiovascular-morbidity-and-mortality-in-critically-ill-patients-undergoing-continuous-renal-replacement-therapy-versus-sustained-low-efficiency-dialysis-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:41:15Z","timestamp":1770187275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/444882-comparing-cardiovascular-morbidity-and-mortality-in-critically-ill-patients-undergoing-continuous-renal-replacement-therapy-versus-sustained-low-efficiency-dialysis-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.102931","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}