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Lancet Neurol. 2009, 8:382-97. 10.1016\/S1474-4422(09)70062-6","journal-title":"Lancet Neurol"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.07.005","article-title":"Alterations of T-lymphocyte populations in Parkinson disease","volume":"11","author":"Baba Y","year":"2005","unstructured":"Baba Y, Kuroiwa A, Uitti RJ, Wszolek ZK, Yamada T. Alterations of T-lymphocyte populations in Parkinson disease. Parkinsonism Relat Disord. 2005, 11:493-8. 10.1016\/j.parkreldis.2005.07.005","journal-title":"Parkinsonism Relat Disord"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90508-8","article-title":"Interleukin-1\u03b2, interleukin-6, epidermal growth factor and transforming growth factor-\u03b1 are elevated in the brain from parkinsonian patients","volume":"180","author":"Mogi M","year":"1994","unstructured":"Mogi M, Harada M, Kondo T, Riederer P, Inagaki H, Minami M, Nagatsu T. Interleukin-1\u03b2, interleukin-6, epidermal growth factor and transforming growth factor-\u03b1 are elevated in the brain from parkinsonian patients. Neurosci Lett. 1994, 180:147-50. 10.1016\/0304-3940(94)90508-8","journal-title":"Neurosci Lett"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo7639","article-title":"Ketogenic diet uncovers differential metabolic plasticity of brain cells","volume":"8","author":"D\u00fcking T","year":"2022","unstructured":"D\u00fcking T, Spieth L, Berghoff SA, et al.. Ketogenic diet uncovers differential metabolic plasticity of brain cells. Sci Adv. 2022, 8:eabo7639. 10.1126\/sciadv.abo7639","journal-title":"Sci Adv"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-320157","article-title":"Clinical implications of early caudate dysfunction in Parkinson's disease","volume":"90","author":"Pasquini J","year":"2019","unstructured":"Pasquini J, Durcan R, Wiblin L, et al.. 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Stoker TB, Greenland JC (ed): Codon Publications, Brisbane, AU; 2018. 10.15586\/codonpublications.parkinsonsdisease.2018.ch9"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.09.017","article-title":"Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease","volume":"15","author":"Grealish S","year":"2014","unstructured":"Grealish S, Diguet E, Kirkeby A, et al.. Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease. Cell Stem Cell. 2014, 15:653-65. 10.1016\/j.stem.2014.09.017","journal-title":"Cell Stem Cell"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8940-21","article-title":"Recent advances in drug therapy for Parkinson\u2019s disease","volume":"62","author":"Murakami H","year":"2023","unstructured":"Murakami H, Shiraishi T, Umehara T, Omoto S, Iguchi Y. Recent advances in drug therapy for Parkinson\u2019s disease. Intern Med. 2023, 62:33-42. 10.2169\/internalmedicine.8940-21","journal-title":"Intern Med"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2022.1765","article-title":"Psychotic symptoms in the context of levodopa treatment in Parkinson\u2019s disease: clinical feature or iatrogenesis?","volume":"65","author":"Costa ML","year":"2022","unstructured":"Costa ML, Cerame A. Psychotic symptoms in the context of levodopa treatment in Parkinson\u2019s disease: clinical feature or iatrogenesis?. 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Neuron. 2010, 68:409-27. 10.1016\/j.neuron.2010.09.043","journal-title":"Neuron"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr165","article-title":"Vascular endothelial growth factor is upregulated by L-dopa in the parkinsonian brain: implications for the development of dyskinesia","volume":"134","author":"Ohlin KE","year":"2011","unstructured":"Ohlin KE, Francardo V, Lindgren HS, et al.. Vascular endothelial growth factor is upregulated by L-dopa in the parkinsonian brain: implications for the development of dyskinesia. Brain. 2011, 134:2339-57. 10.1093\/brain\/awr165","journal-title":"Brain"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.593026","article-title":"Blood-brain barrier leakage is increased in Parkinson\u2019s disease","volume":"11","author":"Al-Bachari S","year":"2020","unstructured":"Al-Bachari S, Naish JH, Parker GJ, Emsley HC, Parkes LM. Blood-brain barrier leakage is increased in Parkinson\u2019s disease. Front Physiol. 2020, 11:593026. 10.3389\/fphys.2020.593026","journal-title":"Front Physiol"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.123","article-title":"Cell-based therapies for Parkinson disease\u2014past insights and future potential","volume":"11","author":"Barker RA","year":"2015","unstructured":"Barker RA, Drouin-Ouellet J, Parmar M. Cell-based therapies for Parkinson disease\u2014past insights and future potential. Nat Rev Neurol. 2015, 11:492-503. 10.1038\/nrneurol.2015.123","journal-title":"Nat Rev Neurol"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092319","article-title":"Induced pluripotent stem cells (iPSCs)-roles in regenerative therapies, disease modelling and drug screening","volume":"10","author":"Aboul-Soud MA","year":"2021","unstructured":"Aboul-Soud MA, Alzahrani AJ, Mahmoud A. Induced pluripotent stem cells (iPSCs)-roles in regenerative therapies, disease modelling and drug screening. Cells. 2021, 10:2319. 10.3390\/cells10092319","journal-title":"Cells"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X2024e13482","article-title":"Revealing induced pluripotent stem cells' potential as a better alternative to embryonic stem cells for Parkinson's disease treatment based on single-cell RNA-seq","volume":"57","author":"Zhang S","year":"2024","unstructured":"Zhang S, Jiang X, Yan M, et al.. Revealing induced pluripotent stem cells' potential as a better alternative to embryonic stem cells for Parkinson's disease treatment based on single-cell RNA-seq. Braz J Med Biol Res. 2024, 57:e13482. 10.1590\/1414-431X2024e13482","journal-title":"Braz J Med Biol Res"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75008-6","article-title":"Elevated caudate connectivity in cognitively normal Parkinson's disease patients","volume":"10","author":"Wright N","year":"2020","unstructured":"Wright N, Alhindi A, Millikin C, et al.. Elevated caudate connectivity in cognitively normal Parkinson's disease patients. Sci Rep. 2020, 10:17978. 10.1038\/s41598-020-75008-6","journal-title":"Sci Rep"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.08.020","article-title":"Distinct brain metabolic patterns separately associated with cognition, motor function, and aging in Parkinson's disease dementia","volume":"60","author":"Ko JH","year":"2017","unstructured":"Ko JH, Katako A, Aljuaid M, et al.. Distinct brain metabolic patterns separately associated with cognition, motor function, and aging in Parkinson's disease dementia. Neurobiol Aging. 2017, 60:81-91. 10.1016\/j.neurobiolaging.2017.08.020","journal-title":"Neurobiol Aging"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz S","year":"2016","unstructured":"Beyaz S, Mana MD, Roper J, et al.. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016, 531:53-8. 10.1038\/nature17173","journal-title":"Nature"},{"key":"ref72","article-title":"Levodopa (L-dopa)","author":"Gandhi KR","year":"2023","unstructured":"Gandhi KR, Saadabadi A. Levodopa (L-dopa). StatPearls. StatPearls Publishing, Treasure Island, FL; 2023."},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440722","article-title":"Levodopa toxicity and apoptosis","volume":"44","author":"Melamed E","year":"1998","unstructured":"Melamed E, Offen D, Shirvan A, Djaldetti R, Barzilai A, Ziv I. Levodopa toxicity and apoptosis. Ann Neurol. 1998, 44:S149-54. 10.1002\/ana.410440722","journal-title":"Ann Neurol"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.nsa.2024.104061","article-title":"Research progress of cell treatment strategy in Parkinson's disease","volume":"3","author":"Peng YL","year":"2024","unstructured":"Peng YL, Chen J, Hu H, Liu W, Liang W, Wang J. Research progress of cell treatment strategy in Parkinson's disease. Neurosci Appl. 2024, 3:104061. 10.1016\/j.nsa.2024.104061","journal-title":"Neurosci Appl"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02176-z","article-title":"Neural stem cells derived from \u03b1-synuclein-knockdown iPS cells alleviate Parkinson's disease","volume":"10","author":"Wang CH","year":"2024","unstructured":"Wang CH, Lin GC, Fu RH, et al.. Neural stem cells derived from \u03b1-synuclein-knockdown iPS cells alleviate Parkinson's disease. Cell Death Discov. 2024, 10:407. 10.1038\/s41420-024-02176-z","journal-title":"Cell Death Discov"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.022438099","article-title":"Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model","volume":"99","author":"Bjorklund LM","year":"2002","unstructured":"Bjorklund LM, S\u00e1nchez-Pernaute R, Chung S, et al.. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002, 99:2344-9. 10.1073\/pnas.022438099","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00681-2","article-title":"The microbiome-gut-brain axis in Parkinson disease\u2014from basic research to the clinic","volume":"18","author":"Tan AH","year":"2022","unstructured":"Tan AH, Lim SY, Lang AE. The microbiome-gut-brain axis in Parkinson disease\u2014from basic research to the clinic. Nat Rev Neurol. 2022, 18:476-95. 10.1038\/s41582-022-00681-2","journal-title":"Nat Rev Neurol"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1101\/gad.346973.120","article-title":"Dietary interventions as regulators of stem cell behavior in homeostasis and disease","volume":"35","author":"Novak JS","year":"2021","unstructured":"Novak JS, Baksh SC, Fuchs E. Dietary interventions as regulators of stem cell behavior in homeostasis and disease. Genes Dev. 2021, 35:199-211. 10.1101\/gad.346973.120","journal-title":"Genes Dev"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101731","article-title":"Calorie restriction protects neural stem cells from age-related deficits in the subventricular zone","volume":"11","author":"Apple DM","year":"2019","unstructured":"Apple DM, Mahesula S, Fonseca RS, Zhu C, Kokovay E. Calorie restriction protects neural stem cells from age-related deficits in the subventricular zone. Aging (Albany NY). 2019, 11:115-26. 10.18632\/aging.101731","journal-title":"Aging (Albany NY)"},{"key":"ref80","article-title":"Dopamine agonists","author":"Choi J","year":"2023","unstructured":"Choi J, Horner KA. Dopamine agonists. StatPearls. StatPearls Publishing, Treasure Island, FL; 2023."},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-240272","article-title":"Parkinson\u2019s disease drug therapies in the clinical trial pipeline: 2024 update","volume":"14","author":"McFarthing K","year":"2024","unstructured":"McFarthing K, Buff S, Rafaloff G, et al.. Parkinson\u2019s disease drug therapies in the clinical trial pipeline: 2024 update. 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