{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T03:45:12Z","timestamp":1770954312937,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,12]]},"DOI":"10.7759\/cureus.103505","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T02:45:58Z","timestamp":1770950758000},"source":"Crossref","is-referenced-by-count":0,"title":["Pathological Analysis of Lateral Lymph Nodes in Patients With Advanced Rectal Cancer After Preoperative Chemoradiotherapy"],"prefix":"10.7759","author":[{"given":"Hiroshi","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kotake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaeko","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuo","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7629","article-title":"Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203","volume":"24","author":"G\u00e9rard JP","year":"2006","unstructured":"G\u00e9rard JP, Conroy T, Bonnetain F, et al.. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol. 2006, 24:4620-5. 10.1200\/JCO.2006.06.7629","journal-title":"J Clin Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060829","article-title":"Chemotherapy with preoperative radiotherapy in rectal cancer","volume":"355","author":"Bosset JF","year":"2006","unstructured":"Bosset JF, Collette L, Calais G, et al.. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006, 355:1114-23. 10.1056\/NEJMoa060829","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer R","year":"2004","unstructured":"Sauer R, Becker H, Hohenberger W, et al.. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004, 351:1731-40. 10.1056\/NEJMoa040694","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182565d9d","article-title":"Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease?","volume":"255","author":"Akiyoshi T","year":"2012","unstructured":"Akiyoshi T, Watanabe T, Miyata S, Kotake K, Muto T, Sugihara K. Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease?. Ann Surg. 2012, 255:1129-34. 10.1097\/SLA.0b013e3182565d9d","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00032","article-title":"Neoadjuvant (chemo)radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter lateral node study of patients with low CT3\/4 rectal cancer","volume":"37","author":"Ogura A","year":"2019","unstructured":"Ogura A, Konishi T, Cunningham C, et al.. Neoadjuvant (chemo)radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter lateral node study of patients with low CT3\/4 rectal cancer. J Clin Oncol. 2019, 37:33-43. 10.1200\/JCO.18.00032","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3216-y","article-title":"Selective lateral pelvic lymph node dissection in patients with advanced low rectal cancer treated with preoperative chemoradiotherapy based on pretreatment imaging","volume":"21","author":"Akiyoshi T","year":"2014","unstructured":"Akiyoshi T, Ueno M, Matsueda K, et al.. Selective lateral pelvic lymph node dissection in patients with advanced low rectal cancer treated with preoperative chemoradiotherapy based on pretreatment imaging. Ann Surg Oncol. 2014, 21:189-96. 10.1245\/s10434-013-3216-y","journal-title":"Ann Surg Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-018-2974-1","article-title":"Outcomes and prognostic factors of selective lateral pelvic lymph node dissection with preoperative chemoradiotherapy for locally advanced rectal cancer","volume":"33","author":"Matsuda T","year":"2018","unstructured":"Matsuda T, Sumi Y, Yamashita K, et al.. Outcomes and prognostic factors of selective lateral pelvic lymph node dissection with preoperative chemoradiotherapy for locally advanced rectal cancer. Int J Colorectal Dis. 2018, 33:367-74. 10.1007\/s00384-018-2974-1","journal-title":"Int J Colorectal Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda Y","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 2013, 48:452-8. 10.1038\/bmt.2012.244","journal-title":"Bone Marrow Transplant"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002212","article-title":"Mesorectal excision with or without lateral lymph node dissection for clinical stage II\/III lower rectal cancer (JCOG0212): a multicenter, randomized controlled, noninferiority trial","volume":"266","author":"Fujita S","year":"2017","unstructured":"Fujita S, Mizusawa J, Kanemitsu Y, et al.. Mesorectal excision with or without lateral lymph node dissection for clinical stage II\/III lower rectal cancer (JCOG0212): a multicenter, randomized controlled, noninferiority trial. Ann Surg. 2017, 266:201-7. 10.1097\/SLA.0000000000002212","journal-title":"Ann Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318190a664","article-title":"A comparison between the treatment of low rectal cancer in Japan and the Netherlands, focusing on the patterns of local recurrence","volume":"249","author":"Kusters M","year":"2009","unstructured":"Kusters M, Beets GL, van de Velde CJ, et al.. A comparison between the treatment of low rectal cancer in Japan and the Netherlands, focusing on the patterns of local recurrence. Ann Surg. 2009, 249:229-35. 10.1097\/SLA.0b013e318190a664","journal-title":"Ann Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010580","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer","volume":"345","author":"Kapiteijn E","year":"2001","unstructured":"Kapiteijn E, Marijnen CA, Nagtegaal ID, et al.. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001, 345:638-46. 10.1056\/NEJMoa010580","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6197-x","article-title":"Oncological outcomes of robotic-assisted laparoscopic versus open lateral lymph node dissection for locally advanced low rectal cancer","volume":"32","author":"Yamaguchi T","year":"2018","unstructured":"Yamaguchi T, Kinugasa Y, Shiomi A, et al.. Oncological outcomes of robotic-assisted laparoscopic versus open lateral lymph node dissection for locally advanced low rectal cancer. Surg Endosc. 2018, 32:4498-505. 10.1007\/s00464-018-6197-x","journal-title":"Surg Endosc"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-019-01485-z","article-title":"Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer","volume":"25","author":"Hashiguchi Y","year":"2020","unstructured":"Hashiguchi Y, Muro K, Saito Y, et al.. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 2020, 25:1-42. 10.1007\/s10147-019-01485-z","journal-title":"Int J Clin Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-022-02537-0","article-title":"Surgical outcomes of robotic, laparoscopic, and open low anterior resection after preoperative chemoradiotherapy for patients with advanced lower rectal cancer","volume":"53","author":"Lim S","year":"2023","unstructured":"Lim S, Nagai Y, Nozawa H, et al.. Surgical outcomes of robotic, laparoscopic, and open low anterior resection after preoperative chemoradiotherapy for patients with advanced lower rectal cancer. Surg Today. 2023, 53:109-15. 10.1007\/s00595-022-02537-0","journal-title":"Surg Today"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234784","article-title":"Randomized, controlled trial of lateral node dissection vs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy","volume":"44","author":"Nagawa H","year":"2001","unstructured":"Nagawa H, Muto T, Sunouchi K, Higuchi Y, Tsurita G, Watanabe T, Sawada T. Randomized, controlled trial of lateral node dissection vs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy. Dis Colon Rectum. 2001, 44:1274-80. 10.1007\/BF02234784","journal-title":"Dis Colon Rectum"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.125357","article-title":"Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers","volume":"132","author":"Watanabe T","year":"2002","unstructured":"Watanabe T, Tsurita G, Muto T, et al.. Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers. Surgery. 2002, 132:27-33. 10.1067\/msy.2002.125357","journal-title":"Surgery"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000752","article-title":"Oncological outcomes of lateral pelvic lymph node metastasis in rectal cancer treated with preoperative chemoradiotherapy","volume":"60","author":"Ishihara S","year":"2017","unstructured":"Ishihara S, Kawai K, Tanaka T, et al.. Oncological outcomes of lateral pelvic lymph node metastasis in rectal cancer treated with preoperative chemoradiotherapy. Dis Colon Rectum. 2017, 60:469-76. 10.1097\/DCR.0000000000000752","journal-title":"Dis Colon Rectum"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/450528-pathological-analysis-of-lateral-lymph-nodes-in-patients-with-advanced-rectal-cancer-after-preoperative-chemoradiotherapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T02:45:59Z","timestamp":1770950759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/450528-pathological-analysis-of-lateral-lymph-nodes-in-patients-with-advanced-rectal-cancer-after-preoperative-chemoradiotherapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.103505","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}