{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:07:07Z","timestamp":1777514827706,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,16]]},"DOI":"10.7759\/cureus.103744","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:04:16Z","timestamp":1771301056000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of Oral Health Status in Patients Undergoing Orthodontic Treatment With Clear Aligner Therapy Versus Conventional Fixed Appliance Therapy: An Umbrella Review"],"prefix":"10.7759","author":[{"given":"Hemannthee","family":"Thota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himaja","family":"Vanteddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hepsi","family":"Singavarapu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hepsiba","family":"A","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pushpika","family":"Sunkara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaitanya Krishna Dev","family":"Pillutla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Clinical limitations of Invisalign","volume":"73","author":"Phan X","year":"2007","unstructured":"Phan X, Ling PH. Clinical limitations of Invisalign. J Can Dent Assoc. 2007, 73:263-6.","journal-title":"J Can Dent Assoc"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(82)90032-x","article-title":"Incidence of white spot formation after bonding and banding","volume":"81","author":"Gorelick L","year":"19821","unstructured":"Gorelick L, Geiger AM, Gwinnett AJ. Incidence of white spot formation after bonding and banding. Am J Orthod. 19821, 81:93-8. 10.1016\/0002-9416(82)90032-x","journal-title":"Am J Orthod"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1971.tb02028.x","article-title":"Caries incidence and oral hygiene during orthodontic treatment","volume":"79","author":"Zachrisson BU","year":"1971","unstructured":"Zachrisson BU, Zachrisson S. Caries incidence and oral hygiene during orthodontic treatment. Scand J Dent Res. 1971, 79:394-401. 10.1111\/j.1600-0722.1971.tb02028.x","journal-title":"Scand J Dent Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-005-0436-1","article-title":"A comparison of the periodontal health of patients during treatment with the Invisalign system and with fixed orthodontic appliances","volume":"66","author":"Miethke RR","year":"2005","unstructured":"Miethke RR, Vogt S. A comparison of the periodontal health of patients during treatment with the Invisalign system and with fixed orthodontic appliances. J Orofac Orthop. 2005, 66:219-29. 10.1007\/s00056-005-0436-1","journal-title":"J Orofac Orthop"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25472","article-title":"The effect of treatment with clear aligners versus fixed appliances on oral health-related quality of life in patients with severe crowding: a one-year follow-up randomized controlled clinical trial","volume":"14","author":"Jaber ST","year":"2022","unstructured":"Jaber ST, Hajeer MY, Burhan AS, Latifeh Y. The effect of treatment with clear aligners versus fixed appliances on oral health-related quality of life in patients with severe crowding: a one-year follow-up randomized controlled clinical trial. Cureus. 2022, 14:e25472. 10.7759\/cureus.25472","journal-title":"Cureus"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38311","article-title":"Treatment effectiveness of clear aligners in correcting complicated and severe malocclusion cases compared to fixed orthodontic appliances: a systematic review","volume":"15","author":"Jaber ST","year":"2023","unstructured":"Jaber ST, Hajeer MY, Sultan K. Treatment effectiveness of clear aligners in correcting complicated and severe malocclusion cases compared to fixed orthodontic appliances: a systematic review. Cureus. 2023, 15:e38311. 10.7759\/cureus.38311","journal-title":"Cureus"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-032-03176-1_29","article-title":"Evaluating the impact of clear dental aligners on dental and periodontal conditions, oral microbial patterns, and the immune system","volume":"1492","author":"Esmaeili S","year":"2026","unstructured":"Esmaeili S, Shahbazi S, Ziaei H, Younessian F. Evaluating the impact of clear dental aligners on dental and periodontal conditions, oral microbial patterns, and the immune system. Adv Exp Med Biol. 2026, 1492:605-24. 10.1007\/978-3-032-03176-1_29","journal-title":"Adv Exp Med Biol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/sci5\/4268902","article-title":"A systematic review of interventions-does Invisalign move teeth as effectively as orthodontic fixed appliances?","volume":"2024","author":"Alam MK","year":"2024","unstructured":"Alam MK, Awawdeh M, Alhazmi N, et al.. A systematic review of interventions-does Invisalign move teeth as effectively as orthodontic fixed appliances?. Scientifica (Cairo). 2024, 2024:4268902. 10.1155\/sci5\/4268902","journal-title":"Scientifica (Cairo)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea BJ","year":"2017","unstructured":"Shea BJ, Reeves BC, Wells G, et al.. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017, 358:j4008. 10.1136\/bmj.j4008","journal-title":"BMJ"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010248","article-title":"Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system. A meta-analysis","volume":"97","author":"Lu H","year":"2018","unstructured":"Lu H, Tang H, Zhou T, Kang N. Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system. A meta-analysis. Medicine (Baltimore). 2018, 97:e0248. 10.1097\/MD.0000000000010248","journal-title":"Medicine (Baltimore)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2018.04.010","article-title":"Periodontal health during orthodontic treatment with clear aligners and fixed appliances. A meta-analysis","volume":"149","author":"Jiang Q","year":"2018","unstructured":"Jiang Q, Li J, Mei L, Du J, Levrini L, Abbate GM, Li H. Periodontal health during orthodontic treatment with clear aligners and fixed appliances. A meta-analysis. J Am Dent Assoc. 2018, 149:712-720.e12. 10.1016\/j.adaj.2018.04.010","journal-title":"J Am Dent Assoc"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.b2403661","article-title":"Impact of aligners and fixed appliances on oral health during orthodontic treatment: a systematic review and meta-analysis","volume":"19","author":"Oikonomou E","year":"2021","unstructured":"Oikonomou E, Foros P, Tagkli A, Rahiotis C, Eliades T, Koletsi D. Impact of aligners and fixed appliances on oral health during orthodontic treatment: a systematic review and meta-analysis. Oral Health Prev Dent. 2021, 19:659-72. 10.3290\/j.ohpd.b2403661","journal-title":"Oral Health Prev Dent"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03257-8","article-title":"White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta-analysis","volume":"23","author":"Raghavan S","year":"2023","unstructured":"Raghavan S, Abu Alhaija ES, Duggal MS, Narasimhan S, Al-Maweri SA. White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta-analysis. BMC Oral Health. 2023, 23:599. 10.1186\/s12903-023-03257-8","journal-title":"BMC Oral Health"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4041\/kjod22.272","article-title":"Periodontal health status, oral microbiome, white-spot lesions and oral health related to quality of life-clear aligners versus fixed appliances: a systematic review, meta-analysis and meta-regression","volume":"53","author":"Llera-Romero AS","year":"2023","unstructured":"Llera-Romero AS, Adobes-Mart\u00edn M, Iranzo-Cort\u00e9s JE, Montiel-Company JM, Garcovich D. Periodontal health status, oral microbiome, white-spot lesions and oral health related to quality of life-clear aligners versus fixed appliances: a systematic review, meta-analysis and meta-regression. Korean J Orthod. 2023, 53:374-92. 10.4041\/kjod22.272","journal-title":"Korean J Orthod"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11091340","article-title":"Impact of clear aligners versus fixed appliances on periodontal status of patients undergoing orthodontic treatment: a systematic review of systematic reviews","volume":"11","author":"Di Spirito F","year":"2023","unstructured":"Di Spirito F, D'Ambrosio F, Cannat\u00e0 D, D'Ant\u00f2 V, Giordano F, Martina S. Impact of clear aligners versus fixed appliances on periodontal status of patients undergoing orthodontic treatment: a systematic review of systematic reviews. Healthcare (Basel). 2023, 11:1340. 10.3390\/healthcare11091340","journal-title":"Healthcare (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.25760","article-title":"Assessment of the periodontal health status and gingival recession during orthodontic treatment with clear aligners and fixed appliances: a systematic review and meta-analysis","volume":"28","author":"Crego-Ruiz M","year":"2023","unstructured":"Crego-Ruiz M, Jorba-Garc\u00eda A. Assessment of the periodontal health status and gingival recession during orthodontic treatment with clear aligners and fixed appliances: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2023, 28:e330-40. 10.4317\/medoral.25760","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/children12020138","article-title":"The differential impact of clear aligners and fixed orthodontic appliances on periodontal health: a systematic review","volume":"12","author":"Dipalma G","year":"2025","unstructured":"Dipalma G, Inchingolo AD, Fiore A, et al.. The differential impact of clear aligners and fixed orthodontic appliances on periodontal health: a systematic review. Children (Basel). 2025, 12:138. 10.3390\/children12020138","journal-title":"Children (Basel)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2023.10.013","article-title":"Impact of various aligner auxiliaries on orthodontic activity: a systematic review and network meta-analysis","volume":"36","author":"Khursheed Alam M","year":"2024","unstructured":"Khursheed Alam M, Hajeer MY, Shqaidef A, et al.. Impact of various aligner auxiliaries on orthodontic activity: a systematic review and network meta-analysis. Saudi Dent J. 2024, 36:199-207. 10.1016\/j.sdentj.2023.10.013","journal-title":"Saudi Dent J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023165","article-title":"The periodontal status of removable appliances vs fixed appliances. A comparative meta-analysis","volume":"99","author":"Wu Y","year":"2020","unstructured":"Wu Y, Cao L, Cong J. The periodontal status of removable appliances vs fixed appliances. A comparative meta-analysis. Medicine (Baltimore). 2020, 99:e23165. 10.1097\/MD.0000000000023165","journal-title":"Medicine (Baltimore)"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2015.45.6.193","article-title":"A comparative study of combined periodontal and orthodontic treatment with fixed appliances and clear aligners in patients with periodontitis","volume":"45","author":"Han JY","year":"2015","unstructured":"Han JY. A comparative study of combined periodontal and orthodontic treatment with fixed appliances and clear aligners in patients with periodontitis. J Periodontal Implant Sci. 2015, 45:193-204. 10.5051\/jpis.2015.45.6.193","journal-title":"J Periodontal Implant Sci"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2319\/031212-217.1","article-title":"Periodontal status of adult patients treated with fixed buccal appliances and removable aligners over one year of active orthodontic therapy","volume":"83","author":"Karkhanechi M","year":"2013","unstructured":"Karkhanechi M, Chow D, Sipkin J, et al.. Periodontal status of adult patients treated with fixed buccal appliances and removable aligners over one year of active orthodontic therapy. Angle Orthod. 2013, 83:146-51. 10.2319\/031212-217.1","journal-title":"Angle Orthod"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10112255","article-title":"Efficacy of home oral-hygiene protocols during orthodontic treatment with multibrackets and clear aligners: microbiological analysis with phase-contrast microscope","volume":"10","author":"Caccianiga P","year":"2022","unstructured":"Caccianiga P, Nota A, Tecco S, Ceraulo S, Caccianiga G. Efficacy of home oral-hygiene protocols during orthodontic treatment with multibrackets and clear aligners: microbiological analysis with phase-contrast microscope. Healthcare (Basel). 2022, 10:2255. 10.3390\/healthcare10112255","journal-title":"Healthcare (Basel)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1590\/2176-9451.19.2.046-055.oar","article-title":"The influence of orthodontic fixed appliances on the oral microbiota: a systematic review","volume":"19","author":"Freitas AO","year":"2014","unstructured":"Freitas AO, Marquezan M, Nojima Mda C, Alviano DS, Maia LC. The influence of orthodontic fixed appliances on the oral microbiota: a systematic review. Dental Press J Orthod. 2014, 19:46-55. 10.1590\/2176-9451.19.2.046-055.oar","journal-title":"Dental Press J Orthod"},{"key":"ref24","article-title":"Effect of orthodontic therapy with fixed and removable appliances on oral microbiota: a six-month longitudinal study","volume":"20","author":"Petti S","year":"1997","unstructured":"Petti S, Barbato E, Simonetti D'Arca A. Effect of orthodontic therapy with fixed and removable appliances on oral microbiota: a six-month longitudinal study. New Microbiol. 1997, 20:55-62.","journal-title":"New Microbiol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-015-0060-4","article-title":"Braces versus Invisalign\u00ae: gingival parameters and patients' satisfaction during treatment: a cross-sectional study","volume":"15","author":"Azaripour A","year":"2015","unstructured":"Azaripour A, Weusmann J, Mahmoodi B, Peppas D, Gerhold-Ay A, Van Noorden CJ, Willershausen B. Braces versus Invisalign\u00ae: gingival parameters and patients' satisfaction during treatment: a cross-sectional study. BMC Oral Health. 2015, 15:69. 10.1186\/s12903-015-0060-4","journal-title":"BMC Oral Health"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4103\/jos.jos_170_21","article-title":"White spot lesions during orthodontic clear aligner therapy. A scoping review","volume":"11","author":"Bisht S","year":"2022","unstructured":"Bisht S, Khera AK, Raghav P. White spot lesions during orthodontic clear aligner therapy. A scoping review. J Orthod Sci. 2022, 11:9. 10.4103\/jos.jos_170_21","journal-title":"J Orthod Sci"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2021.10.015","article-title":"The impact of fixed orthodontic appliances and clear aligners on the oral microbiome and the association with clinical parameters: a longitudinal comparative study","volume":"161","author":"Shokeen B","year":"2022","unstructured":"Shokeen B, Viloria E, Duong E, et al.. The impact of fixed orthodontic appliances and clear aligners on the oral microbiome and the association with clinical parameters: a longitudinal comparative study. Am J Orthod Dentofacial Orthop. 2022, 161:e475-85. 10.1016\/j.ajodo.2021.10.015","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/app14219931","article-title":"Evaluating clear aligners versus fixed appliances for periodontal patients: a comprehensive narrative review of current evidence","volume":"30","author":"Samulak R","year":"2024","unstructured":"Samulak R, Suwa\u0142a M, G\u00f3rski B, Machoy M. Evaluating clear aligners versus fixed appliances for periodontal patients: a comprehensive narrative review of current evidence. App Sci. 2024, 30:9931. 10.3390\/app14219931","journal-title":"App Sci"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/dj13020070","article-title":"Orthodontic treatment with fixed appliances versus aligners: an experimental study of periodontal aspects","volume":"13","author":"Giannini L","year":"2025","unstructured":"Giannini L, Galbiati G, Tartaglia FC, Grecolini ME, Maspero C, Biagi R. Orthodontic treatment with fixed appliances versus aligners: an experimental study of periodontal aspects. Dent J (Basel). 2025, 13:70. 10.3390\/dj13020070","journal-title":"Dent J (Basel)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.30.3.e252531.oar","article-title":"Gingival changes after removal of fixed orthodontic appliances: a prospective cohort clinical study","volume":"30","author":"Tavares LC","year":"2025","unstructured":"Tavares LC, Gouv\u00eaa Filho LC, Chaoubah A, et al.. Gingival changes after removal of fixed orthodontic appliances: a prospective cohort clinical study. Dental Press J Orthod. 2025, 30:e252531. 10.1590\/2177-6709.30.3.e252531.oar","journal-title":"Dental Press J Orthod"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/dj13070322","article-title":"Comparison of oral microbial profile among patients undergoing clear aligner and fixed orthodontic therapies for the treatment of malocclusions: an updated review","volume":"13","author":"Ponton E","year":"2025","unstructured":"Ponton E, Rossouw PE, Javed F. Comparison of oral microbial profile among patients undergoing clear aligner and fixed orthodontic therapies for the treatment of malocclusions: an updated review. Dent J (Basel). 2025, 13:322. 10.3390\/dj13070322","journal-title":"Dent J (Basel)"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/dj8010004","article-title":"Impact of fixed orthodontic appliance and clear aligners on the periodontal health: a prospective clinical study","volume":"8","author":"Madariaga AC","year":"2020","unstructured":"Madariaga AC, Bucci R, Rongo R, Simeon V, D'Ant\u00f2 V, Valletta R. Impact of fixed orthodontic appliance and clear aligners on the periodontal health: a prospective clinical study. Dent J (Basel). 2020, 8:4. 10.3390\/dj8010004","journal-title":"Dent J (Basel)"},{"key":"ref33","article-title":"Clear aligners vs. fixed orthodontic appliances: effects on periodontal health and plaque accumulation","volume":"30","author":"Khan TU","year":"2023","unstructured":"Khan TU, Ali F, Rasheed S, Saleem B, Bai D. Clear aligners vs. fixed orthodontic appliances: effects on periodontal health and plaque accumulation. Innovative Research Journal of Dentistry. 2023, 30:10-7.","journal-title":"Innovative Research Journal of Dentistry"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2319\/073118-553.1","article-title":"Incidence of white spot lesions among patients treated with clear aligners and traditional braces","volume":"89","author":"Buschang PH","year":"2019","unstructured":"Buschang PH, Chastain D, Keylor CL, Crosby D, Julien KC. Incidence of white spot lesions among patients treated with clear aligners and traditional braces. Angle Orthod. 2019, 89:359-64. 10.2319\/073118-553.1","journal-title":"Angle Orthod"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.b965741","article-title":"Effects of self-ligating orthodontic appliances on the periodontal health of adolescents: a prospective cohort study","volume":"19","author":"Papadimitriou A","year":"2021","unstructured":"Papadimitriou A, Kouvelis G, Fanaropoulou T, Doulis I, Kyriakoula M, Mparmpouni A, Kloukos D. Effects of self-ligating orthodontic appliances on the periodontal health of adolescents: a prospective cohort study. Oral Health Prev Dent. 2021, 19:129-35. 10.3290\/j.ohpd.b965741","journal-title":"Oral Health Prev Dent"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60071139","article-title":"The impact of non-extraction orthodontic treatment on the oral-health-related quality of life between a modified aligner appliance with Ni-Ti springs and the traditional fixed appliances: a randomized controlled clinical trialand plaque accumulation","volume":"60","author":"Alhafi ZM","year":"2024","unstructured":"Alhafi ZM, Hajeer MY, Latifeh Y, et al.. The impact of non-extraction orthodontic treatment on the oral-health-related quality of life between a modified aligner appliance with Ni-Ti springs and the traditional fixed appliances: a randomized controlled clinical trialand plaque accumulation. Medicina (Kaunas). 2024, 60:1139. 10.3390\/medicina60071139","journal-title":"Medicina (Kaunas)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/444208-comparative-evaluation-of-oral-health-status-in-patients-undergoing-orthodontic-treatment-with-clear-aligner-therapy-versus-conventional-fixed-appliance-therapy-an-umbrella-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:04:17Z","timestamp":1771301057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/444208-comparative-evaluation-of-oral-health-status-in-patients-undergoing-orthodontic-treatment-with-clear-aligner-therapy-versus-conventional-fixed-appliance-therapy-an-umbrella-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":36,"URL":"https:\/\/doi.org\/10.7759\/cureus.103744","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,16]]}}}