{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:44:14Z","timestamp":1771328654130,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,17]]},"DOI":"10.7759\/cureus.103761","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T10:59:11Z","timestamp":1771325951000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunocompetent but Not Immune: A Prolonged Course of Cryptococcal Meningitis"],"prefix":"10.7759","author":[{"given":"Carlos","family":"Fagundo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Rahman","family":"Omari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america","volume":"50","author":"Perfect JR","year":"2010","unstructured":"Perfect JR, Dismukes WE, Dromer F, et al.. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin Infect Dis. 2010, 50:291-322. 10.1086\/649858","journal-title":"Clin Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75241","article-title":"Cryptococcosis: a model for the understanding of infectious diseases","volume":"124","author":"Perfect JR","year":"2014","unstructured":"Perfect JR. Cryptococcosis: a model for the understanding of infectious diseases. J Clin Invest. 2014, 124:1893-5. 10.1172\/JCI75241","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00731-4","article-title":"Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM","volume":"24","author":"Chang CC","year":"2024","unstructured":"Chang CC, Harrison TS, Bicanic TA, et al.. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM. Lancet Infect Dis. 2024, 24:e495-512. 10.1016\/S1473-3099(23)00731-4","journal-title":"Lancet Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad420","article-title":"Cryptococcal meningitis in young, immunocompetent patients: a single-center retrospective case series and review of the literature","volume":"10","author":"Stack M","year":"2023","unstructured":"Stack M, Hiles J, Valinetz E, Gupta SK, Butt S, Schneider JG. Cryptococcal meningitis in young, immunocompetent patients: a single-center retrospective case series and review of the literature. Open Forum Infect Dis. 2023, 10:ofad420. 10.1093\/ofid\/ofad420","journal-title":"Open Forum Infect Dis"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4894","article-title":"Cryptococcal meningitis in an immunocompetent individual: a case report","volume":"9","author":"Acharya S","year":"2021","unstructured":"Acharya S, Yadav SK, Singh PB, et al.. Cryptococcal meningitis in an immunocompetent individual: a case report. Clin Case Rep. 2021, 9:e04894. 10.1002\/ccr3.4894","journal-title":"Clin Case Rep"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3171\/2015.4.JNS15255","article-title":"Shunting in cryptococcal meningitis","volume":"125","author":"Cherian J","year":"2016","unstructured":"Cherian J, Atmar RL, Gopinath SP. Shunting in cryptococcal meningitis. J Neurosurg. 2016, 125:177-86. 10.3171\/2015.4.JNS15255","journal-title":"J Neurosurg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00511-0","article-title":"Treatment strategies for cryptococcal infection: challenges, advances and future outlook","volume":"19","author":"Iyer KR","year":"2021","unstructured":"Iyer KR, Revie NM, Fu C, Robbins N, Cowen LE. Treatment strategies for cryptococcal infection: challenges, advances and future outlook. Nat Rev Microbiol. 2021, 19:454-66. 10.1038\/s41579-021-00511-0","journal-title":"Nat Rev Microbiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12111303","article-title":"Cryptococcal meningoencephalitis in phenotypically normal patients","volume":"12","author":"Cumagun PM","year":"2023","unstructured":"Cumagun PM, Moore MK, McCarty TP, McGwin G, Pappas PG. Cryptococcal meningoencephalitis in phenotypically normal patients. Pathogens. 2023, 12:10.3390\/pathogens12111303","journal-title":"Pathogens"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.08.004","article-title":"Outcomes of HIV-positive patients with cryptococcal meningitis in the Americas","volume":"63","author":"Crabtree Ram\u00edrez B","year":"2017","unstructured":"Crabtree Ram\u00edrez B, Caro Vega Y, Shepherd BE, et al.. Outcomes of HIV-positive patients with cryptococcal meningitis in the Americas. Int J Infect Dis. 2017, 63:57-63. 10.1016\/j.ijid.2017.08.004","journal-title":"Int J Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit641","article-title":"Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid","volume":"58","author":"Kabanda T","year":"2014","unstructured":"Kabanda T, Siedner MJ, Klausner JD, Muzoora C, Boulware DR. Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid. Clin Infect Dis. 2014, 58:113-6. 10.1093\/cid\/cit641","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00988","article-title":"Diabetes mellitus as a risk factor for cryptococcal meningitis in immunocompetent","volume":"22","author":"Acharya R","year":"2020","unstructured":"Acharya R, Khanal K, Upadhyaya P, Kafle S, Savaliya V. Diabetes mellitus as a risk factor for cryptococcal meningitis in immunocompetent. IDCases. 2020, 22:e00988. 10.1016\/j.idcr.2020.e00988","journal-title":"IDCases"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-015-0046-y","article-title":"Cryptococcal meningitis: diagnosis and management update","volume":"2","author":"Abassi M","year":"2015","unstructured":"Abassi M, Boulware DR, Rhein J. Cryptococcal meningitis: diagnosis and management update. Curr Trop Med Rep. 2015, 2:90-9. 10.1007\/s40475-015-0046-y","journal-title":"Curr Trop Med Rep"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac416","article-title":"Therapeutic lumbar punctures in human immunodeficiency virus-associated cryptococcal meningitis: should opening pressure direct management?","volume":"9","author":"Kagimu E","year":"2022","unstructured":"Kagimu E, Engen N, Ssebambulidde K, et al.. Therapeutic lumbar punctures in human immunodeficiency virus-associated cryptococcal meningitis: should opening pressure direct management?. Open Forum Infect Dis. 2022, 9:ofac416. 10.1093\/ofid\/ofac416","journal-title":"Open Forum Infect Dis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1053-0","article-title":"Ventriculoperitoneal shunts in non-HIV cryptococcal meningitis","volume":"18","author":"Liu J","year":"2018","unstructured":"Liu J, Chen ZL, Li M, et al.. Ventriculoperitoneal shunts in non-HIV cryptococcal meningitis. BMC Neurol. 2018, 18:58. 10.1186\/s12883-018-1053-0","journal-title":"BMC Neurol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/20499361241228666","article-title":"Cerebrospinal fluid shunting for the management of cryptococcal meningitis: a scoping review","volume":"11","author":"Cornejo-Venegas G","year":"2024","unstructured":"Cornejo-Venegas G, Carreras X, Salcedo AS, Soriano-Moreno DR, Salinas JL, Alave J. Cerebrospinal fluid shunting for the management of cryptococcal meningitis: a scoping review. Ther Adv Infect Dis. 2024, 11:20499361241228666. 10.1177\/20499361241228666","journal-title":"Ther Adv Infect Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.773334","article-title":"Short-term and long-term outcomes in patients with cryptococcal meningitis after ventriculoperitoneal shunt placement","volume":"13","author":"Wen J","year":"2022","unstructured":"Wen J, Yin R, Chang J, et al.. Short-term and long-term outcomes in patients with cryptococcal meningitis after ventriculoperitoneal shunt placement. Front Neurol. 2022, 13:773334. 10.3389\/fneur.2022.773334","journal-title":"Front Neurol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/462065-immunocompetent-but-not-immune-a-prolonged-course-of-cryptococcal-meningitis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T10:59:11Z","timestamp":1771325951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/462065-immunocompetent-but-not-immune-a-prolonged-course-of-cryptococcal-meningitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.103761","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,17]]}}}