{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:17:01Z","timestamp":1771399021634,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,17]]},"DOI":"10.7759\/cureus.103810","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:30:08Z","timestamp":1771396208000},"source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Hypoxic Ischemic Encephalopathy and Multiorgan Dysfunction in Late Preterm and Term Infants Receiving Resuscitation Beyond Initial Steps at Birth"],"prefix":"10.7759","author":[{"given":"Parul","family":"Sohane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakal   N","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpita","family":"Bhriguvanshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Perinatal asphyxia. (2012). Accessed. 2025: https:\/\/www.who.int\/teams\/maternal-newborn-child-adolescent-health-and-ageing\/newborn-health\/perinatal-asphyxia."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03652-5","article-title":"Neonatal mortality associated with perinatal asphyxia: a population-based study in a middle-income country","volume":"21","author":"Kawakami MD","year":"2021","unstructured":"Kawakami MD, Sanudo A, Teixeira ML, et al.. Neonatal mortality associated with perinatal asphyxia: a population-based study in a middle-income country. BMC Pregnancy Childbirth. 2021, 21:169. 10.1186\/s12884-021-03652-5","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00489","article-title":"A global view of neonatal asphyxia and resuscitation","volume":"7","author":"Moshiro R","year":"2019","unstructured":"Moshiro R, Mdoe P, Perlman JM. A global view of neonatal asphyxia and resuscitation. Front Pediatr. 2019, 7:489. 10.3389\/fped.2019.00489","journal-title":"Front Pediatr"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0026-5","article-title":"Post-resuscitation management of asphyxiated neonates","volume":"75","author":"Agarwal R","year":"2008","unstructured":"Agarwal R, Jain A, Deorari AK, Paul VK. Post-resuscitation management of asphyxiated neonates. Indian J Pediatr. 2008, 75:175-80. 10.1007\/s12098-008-0026-5","journal-title":"Indian J Pediatr"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2016.04.006","article-title":"Cardiovascular alterations and multi organ dysfunction after birth asphyxia","volume":"43","author":"Polglase GR","year":"2016","unstructured":"Polglase GR, Ong T, Hillman NH. Cardiovascular alterations and multi organ dysfunction after birth asphyxia. Clin Perinatol. 2016, 43:469-83. 10.1016\/j.clp.2016.04.006","journal-title":"Clin Perinatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-025-03978-2","article-title":"Multi-organ dysfunction across the neonatal encephalopathy spectrum","volume":"98","author":"Bitar L","year":"2025","unstructured":"Bitar L, Leon RL, Liu YL, Kota S, Chalak LF. Multi-organ dysfunction across the neonatal encephalopathy spectrum. Pediatr Res. 2025, 98:1849-55. 10.1038\/s41390-025-03978-2","journal-title":"Pediatr Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2023.105775","article-title":"Multi-organ dysfunction in infants with acidosis at birth in the absence of moderate to severe hypoxic ischemic encephalopathy","volume":"181","author":"Demirel N","year":"2023","unstructured":"Demirel N, Unal S, Durukan M, Celik \u0130H, Bas AY. Multi-organ dysfunction in infants with acidosis at birth in the absence of moderate to severe hypoxic ischemic encephalopathy. Early Hum Dev. 2023, 181:105775. 10.1016\/j.earlhumdev.2023.105775","journal-title":"Early Hum Dev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2023-002403","article-title":"Incidence and predictors of mortality among neonates admitted with birth asphyxia to neonatal intensive care unit of West Shewa Zone Public Hospitals, Central Ethiopia","volume":"8","author":"Bekele GG","year":"2024","unstructured":"Bekele GG, Roga EY, Gonfa DN, Geda GM. Incidence and predictors of mortality among neonates admitted with birth asphyxia to neonatal intensive care unit of West Shewa Zone Public Hospitals, Central Ethiopia. BMJ Paediatr Open. 2024, 8:002403. 10.1136\/bmjpo-2023-002403","journal-title":"BMJ Paediatr Open"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.39.3.129","article-title":"Hemodynamic instability in hypoxic ischemic encephalopathy: more than just brain injury-understanding physiology, assessment, and management","volume":"39","author":"Habib S","year":"2020","unstructured":"Habib S, Saini J, Amendoeira S, McNair C. Hemodynamic instability in hypoxic ischemic encephalopathy: more than just brain injury-understanding physiology, assessment, and management. Neonatal Netw. 2020, 39:129-36. 10.1891\/0730-0832.39.3.129","journal-title":"Neonatal Netw"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2025.100785","article-title":"Early neonatal deaths with perinatal asphyxia of newborns \u2265 37-weeks in Brazil, 2000\u20122020","volume":"80","author":"de Almeida MF","year":"2025","unstructured":"de Almeida MF, Marinonio AS, Costa-Nobre DT, et al.. Early neonatal deaths with perinatal asphyxia of newborns \u2265 37-weeks in Brazil, 2000\u20122020. Clinics (Sao Paulo). 2025, 80:100785. 10.1016\/j.clinsp.2025.100785","journal-title":"Clinics (Sao Paulo)"},{"key":"ref11","article-title":"Neonatal encephalopathy and neurologic outcome","volume":"123","author":"D\u2019Alton ME","year":"1953","unstructured":"D\u2019Alton ME, Hankins GD, Berkowitz RL, et al.. Neonatal encephalopathy and neurologic outcome. Obstetr Gynecol. 1953, 123:896-901.","journal-title":"Obstetr Gynecol"},{"key":"ref12","unstructured":"Hypoxic ischaemic encephalopathy (HIE). (2021). Accessed. 2025: https:\/\/www.health.qld.gov.au\/__data\/assets\/pdf_file\/0014\/140162\/g-hie.pdf."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat HB","year":"1976","unstructured":"Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976, 33:696-705. 10.1001\/archneur.1976.00500100030012","journal-title":"Arch Neurol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000902","article-title":"Part 5: neonatal resuscitation: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"142","author":"Aziz K","year":"2020","unstructured":"Aziz K, Lee HC, Escobedo MB, et al.. Part 5: neonatal resuscitation: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2020, 142:S524-50. 10.1161\/CIR.0000000000000902","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109608","article-title":"SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores","volume":"138","author":"Richardson DK","year":"2001","unstructured":"Richardson DK, Corcoran JD, Escobar GJ, Lee SK. SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores. J Pediatr. 2001, 138:92-100. 10.1067\/mpd.2001.109608","journal-title":"J Pediatr"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001068","article-title":"The severity of hypoxic-ischemic encephalopathy correlates with multiple organ dysfunction in the hypothermia era","volume":"18","author":"Alsina M","year":"2017","unstructured":"Alsina M, Mart\u00edn-Ancel A, Alarcon-Allen A, Arca G, Gay\u00e1 F, Garc\u00eda-Alix A. The severity of hypoxic-ischemic encephalopathy correlates with multiple organ dysfunction in the hypothermia era. Pediatr Crit Care Med. 2017, 18:234-40. 10.1097\/PCC.0000000000001068","journal-title":"Pediatr Crit Care Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2002.125","article-title":"International Federation of Clinical Chemistry and Laboratory Medicine. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. International Federation of Clinical Chemistry and Laboratory Medicine. Part 5. Reference procedure for the measurement of catalytic concentration of aspartate aminotransferase.","volume":"40","author":"Schumann G","year":"2022","unstructured":"Schumann G, Bonora R, Ceriotti F, et al.. International Federation of Clinical Chemistry and Laboratory Medicine. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. International Federation of Clinical Chemistry and Laboratory Medicine. Part 5. Reference procedure for the measurement of catalytic concentration of aspartate aminotransferase.. Clin Chem Lab Med. 2022, 40:725-33. 10.1515\/CCLM.2002.125","journal-title":"Clin Chem Lab Med"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/31.11.1779","article-title":"Candidate reference method for determination of total bilirubin in serum: development and validation","volume":"31","author":"Doumas BT","year":"1985","unstructured":"Doumas BT, Kwok-Cheung PP, Perry BW, et al.. Candidate reference method for determination of total bilirubin in serum: development and validation. Clin Chem. 1985, 31:1779-89.","journal-title":"Clin Chem"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.023093","article-title":"Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy","volume":"89","author":"Shah P","year":"2004","unstructured":"Shah P, Riphagen S, Beyene J, Perlman M. Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2004, 89:F152-5. 10.1136\/adc.2002.023093","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref20","unstructured":"National Neonatal Perinatal Database Report 2002-2003. (2005). Accessed. 2025: http:\/\/www.newbornwhocc.org\/pdf\/nnpd_report_2002-03.pdf."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-017-0876-y","article-title":"Prevalence, severity and early outcomes of hypoxic ischemic encephalopathy among newborns at a tertiary hospital, in northern Tanzania","volume":"17","author":"Simiyu IN","year":"2017","unstructured":"Simiyu IN, Mchaile DN, Katsongeri K, Philemon RN, Msuya SE. Prevalence, severity and early outcomes of hypoxic ischemic encephalopathy among newborns at a tertiary hospital, in northern Tanzania. BMC Pediatr. 2017, 17:131. 10.1186\/s12887-017-0876-y","journal-title":"BMC Pediatr"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.7196\/sajch.574","article-title":"Outcomes of neonates with perinatal asphyxia at a tertiary academic hospital in Johannesburg, South Africa","volume":"7","author":"Padayachee N","year":"2013","unstructured":"Padayachee N, Ballot DE. Outcomes of neonates with perinatal asphyxia at a tertiary academic hospital in Johannesburg, South Africa. S Afr J Child Health. 2013, 7:89-94.","journal-title":"S Afr J Child Health"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0456","article-title":"Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy","volume":"122","author":"Shankaran S","year":"2008","unstructured":"Shankaran S, Pappas A, Laptook AR, et al.. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2008, 122:e791-8. 10.1542\/peds.2008-0456","journal-title":"Pediatrics"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123204","article-title":"Use of umbilical artery base excess: algorithm for the timing of hypoxic injury","volume":"187","author":"Ross MG","year":"2002","unstructured":"Ross MG, Gala R. Use of umbilical artery base excess: algorithm for the timing of hypoxic injury. Am J Obstet Gynecol. 2002, 187:1-9. 10.1067\/mob.2002.123204","journal-title":"Am J Obstet Gynecol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3126\/jnps.v29i1.1592","article-title":"Profile of asphyxiated babies at Tribhuvan university teaching hospital","volume":"29","author":"Shrestha M","year":"2009","unstructured":"Shrestha M, Shrestha L, Shrestha PS. Profile of asphyxiated babies at Tribhuvan university teaching hospital. J Nepal Paediatr Soc. 2009, 29:3-5. 10.3126\/jnps.v29i1.1592","journal-title":"J Nepal Paediatr Soc"},{"key":"ref26","article-title":"Neuroprotective effects of geneticin (G418) via apoptosis in perinatal hypoxic-ischemic brain injury","volume":"51","author":"Ju M","year":"2008","unstructured":"Ju M, Lee HJ, Lee SJ, et al.. Neuroprotective effects of geneticin (G418) via apoptosis in perinatal hypoxic-ischemic brain injury. Korean J Pediatr. 2008, 51:170-80.","journal-title":"Korean J Pediatr"},{"key":"ref27","article-title":"Risk factors of birth asphyxia: a study at Prince Ali Ben Al-Hussein Hospital, Jordan","volume":"21","author":"Khreisat WH","year":"2005","unstructured":"Khreisat WH, Habahbeh Z. Risk factors of birth asphyxia: a study at Prince Ali Ben Al-Hussein Hospital, Jordan. Pak J Med Sci. 2005, 21:30-4.","journal-title":"Pak J Med Sci"},{"key":"ref28","article-title":"Pediatric Critical Care Medicine: Basic Science and Clinical Evidence","author":"Wheeler DS","year":"2007","unstructured":"Wheeler DS, Wong HR. Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. Springer-Verlag, London, UK; 2007."},{"key":"ref29","article-title":"Postresuscitative management of asphyxiated term\/preterm infant","volume":"11","author":"Tekin N","year":"2003","unstructured":"Tekin N. Postresuscitative management of asphyxiated term\/preterm infant. Turk J Perinatol. 2003, 11:78-84.","journal-title":"Turk J Perinatol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(02)01959-2","article-title":"Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy","volume":"99","author":"Hankins GD","year":"2002","unstructured":"Hankins GD, Koen S, Gei AF, et al.. Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy. Obstet Gynecol. 2002, 99:688-91. 10.1016\/s0029-7844(02)01959-2","journal-title":"Obstet Gynecol"},{"key":"ref31","article-title":"Multi-organ dysfunction in neonates with hypoxic-ischemic encephalopathy","volume":"78","author":"Mohammed LH","year":"2010","unstructured":"Mohammed LH, Khairy MA, El-Hussieny NA, Zaazou NH, Aly RM. Multi-organ dysfunction in neonates with hypoxic-ischemic encephalopathy. Med J Cairo Univ. 2010, 78:461-7.","journal-title":"Med J Cairo Univ"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(02)02577-2","article-title":"Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy","volume":"101","author":"Chauhan SP","year":"2003","unstructured":"Chauhan SP, Magann EF, Morrison JC. Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy. Obstet Gynecol. 2003, 101:203. 10.1016\/s0029-7844(02)02577-2","journal-title":"Obstet Gynecol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/444326-prevalence-of-hypoxic-ischemic-encephalopathy-and-multiorgan-dysfunction-in-late-preterm-and-term-infants-receiving-resuscitation-beyond-initial-steps-at-birth","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:30:10Z","timestamp":1771396210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/444326-prevalence-of-hypoxic-ischemic-encephalopathy-and-multiorgan-dysfunction-in-late-preterm-and-term-infants-receiving-resuscitation-beyond-initial-steps-at-birth"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":32,"URL":"https:\/\/doi.org\/10.7759\/cureus.103810","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,17]]}}}