{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T15:10:22Z","timestamp":1771600222512,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,20]]},"DOI":"10.7759\/cureus.103973","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:24:52Z","timestamp":1771597492000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Intradiscal Condoliase Injection for Lumbar Disc Herniation: A Retrospective Analysis of the First 100 Cases"],"prefix":"10.7759","author":[{"given":"Atsushi","family":"Kojima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Tsujishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kamitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Sodeyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Koda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.08.003","article-title":"An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy","volume":"14","author":"Kreiner DS","year":"2014","unstructured":"Kreiner DS, Hwang SW, Easa JE, et al.. An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J. 2014, 14:180-91. 10.1016\/j.spinee.2013.08.003","journal-title":"Spine J"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002528","article-title":"Condoliase for the treatment of lumbar disc herniation: a randomized controlled trial","volume":"43","author":"Chiba K","year":"2018","unstructured":"Chiba K, Matsuyama Y, Seo T, Toyama Y. Condoliase for the treatment of lumbar disc herniation: a randomized controlled trial. Spine (Phila Pa 1976). 2018, 43:E869-76. 10.1097\/BRS.0000000000002528","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3171\/2017.7.SPINE161327","article-title":"A multicenter, randomized, double-blind, dose-finding study of condoliase in patients with lumbar disc herniation","volume":"28","author":"Matsuyama Y","year":"2018","unstructured":"Matsuyama Y, Chiba K, Iwata H, Seo T, Toyama Y. A multicenter, randomized, double-blind, dose-finding study of condoliase in patients with lumbar disc herniation. J Neurosurg Spine. 2018, 28:499-511. 10.3171\/2017.7.SPINE161327","journal-title":"J Neurosurg Spine"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.22603\/ssrr.2021-0035","article-title":"Efficacy and safety of condoliase disc administration as a new treatment for lumbar disc herniation","volume":"6","author":"Inoue M","year":"2022","unstructured":"Inoue M, Sainoh T, Kojima A, et al.. Efficacy and safety of condoliase disc administration as a new treatment for lumbar disc herniation. Spine Surg Relat Res. 2022, 6:31-7. 10.22603\/ssrr.2021-0035","journal-title":"Spine Surg Relat Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.1.3336678","article-title":"Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging","volume":"166","author":"Modic MT","year":"1988","unstructured":"Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988, 166:193-9. 10.1148\/radiology.166.1.3336678","journal-title":"Radiology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200109010-00011","article-title":"Magnetic resonance classification of lumbar intervertebral disc degeneration","volume":"26","author":"Pfirrmann CW","year":"2001","unstructured":"Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001, 26:1873-8. 10.1097\/00007632-200109010-00011","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90884-8","article-title":"Measurement of pain","volume":"2","author":"Huskisson EC","year":"1974","unstructured":"Huskisson EC. Measurement of pain. Lancet. 1974, 2:1127-31. 10.1016\/S0140-6736(74)90884-8","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58091284","article-title":"Multicenter retrospective analysis of intradiscal condoliase injection therapy for lumbar disc herniation","volume":"58","author":"Oshita Y","year":"2022","unstructured":"Oshita Y, Matsuyama D, Sakai D, et al.. Multicenter retrospective analysis of intradiscal condoliase injection therapy for lumbar disc herniation. Medicina (Kaunas). 2022, 58:1284. 10.3390\/medicina58091284","journal-title":"Medicina (Kaunas)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.20.2441","article-title":"Surgical vs nonoperative treatment for lumbar disk herniation: the spine patient outcomes research trial (SPORT): a randomized trial","volume":"296","author":"Weinstein JN","year":"2006","unstructured":"Weinstein JN, Tosteson TD, Lurie JD, et al.. Surgical vs nonoperative treatment for lumbar disk herniation: the spine patient outcomes research trial (SPORT): a randomized trial. JAMA. 2006, 296:2441-50. 10.1001\/jama.296.20.2441","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59091561","article-title":"Intradiscal condoliase injection therapy for recurrent lumbar disc herniation: case series and literature review","volume":"59","author":"Fukui H","year":"2023","unstructured":"Fukui H, Kamei N, Fujiwara Y, Nakamae T, Ohta R, Kotaka S, Adachi N. Intradiscal condoliase injection therapy for recurrent lumbar disc herniation: case series and literature review. Medicina (Kaunas). 2023, 59:1561. 10.3390\/medicina59091561","journal-title":"Medicina (Kaunas)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.22603\/ssrr.2021-0151","article-title":"Intradiscal injection with condoliase (chondroitin sulfate ABC endolyase) for painful radiculopathy caused by lumbar disc herniation","volume":"6","author":"Hirai T","year":"2022","unstructured":"Hirai T, Takahashi T, Tanaka T, et al.. Intradiscal injection with condoliase (chondroitin sulfate ABC endolyase) for painful radiculopathy caused by lumbar disc herniation. Spine Surg Relat Res. 2022, 6:252-60. 10.22603\/ssrr.2021-0151","journal-title":"Spine Surg Relat Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000158954.68522.2a","article-title":"Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the maine lumbar spine study","volume":"30","author":"Atlas SJ","year":"2005","unstructured":"Atlas SJ, Keller RB, Wu YA, Deyo RA, Singer DE. Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the maine lumbar spine study. Spine (Phila Pa 1976). 2005, 30:927-35. 10.1097\/01.brs.0000158954.68522.2a","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2020.02.002","article-title":"Clinical outcome of condoliase injection treatment for lumbar disc herniation: indications for condoliase therapy","volume":"26","author":"Banno T","year":"2021","unstructured":"Banno T, Hasegawa T, Yamato Y, et al.. Clinical outcome of condoliase injection treatment for lumbar disc herniation: indications for condoliase therapy. J Orthop Sci. 2021, 26:79-85. 10.1016\/j.jos.2020.02.002","journal-title":"J Orthop Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2006.12.004","article-title":"Magnetic resonance imaging findings as predictors of clinical outcome in patients with sciatica receiving active conservative treatment","volume":"30","author":"Jensen TS","year":"2007","unstructured":"Jensen TS, Albert HB, Sorensen JS, Manniche C, Leboeuf-Yde C. Magnetic resonance imaging findings as predictors of clinical outcome in patients with sciatica receiving active conservative treatment. J Manipulative Physiol Ther. 2007, 30:98-108. 10.1016\/j.jmpt.2006.12.004","journal-title":"J Manipulative Physiol Ther"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2022.04.003","article-title":"Condoliase chemonucleolysis for lumbar disc herniation: a post-hoc follow-up study of patients in previous clinical trials","volume":"28","author":"Matsuyama Y","year":"2023","unstructured":"Matsuyama Y, Seo T, Chiba K. Condoliase chemonucleolysis for lumbar disc herniation: a post-hoc follow-up study of patients in previous clinical trials. J Orthop Sci. 2023, 28:724-32. 10.1016\/j.jos.2022.04.003","journal-title":"J Orthop Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2025.11.007","article-title":"Disc level-specific outcomes of intradiscal condoliase injection for lumbar disc herniation: a multicenter retrospective study","volume":"0","author":"Watanabe K","year":"2025","unstructured":"Watanabe K, Takahashi Y, Michikawa T, et al.. Disc level-specific outcomes of intradiscal condoliase injection for lumbar disc herniation: a multicenter retrospective study. J Orthop Sci. 2025, 0:0. 10.1016\/j.jos.2025.11.007","journal-title":"J Orthop Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/460923-clinical-outcomes-of-intradiscal-condoliase-injection-for-lumbar-disc-herniation-a-retrospective-analysis-of-the-first-100-cases","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:24:52Z","timestamp":1771597492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/460923-clinical-outcomes-of-intradiscal-condoliase-injection-for-lumbar-disc-herniation-a-retrospective-analysis-of-the-first-100-cases"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.103973","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,20]]}}}