{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:58:42Z","timestamp":1771844322395,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,23]]},"DOI":"10.7759\/cureus.104098","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:01:33Z","timestamp":1771840893000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Palonosetron\u2013Dexamethasone Versus Granisetron\u2013Dexamethasone for Prevention of Postoperative Nausea and Vomiting: A Review With Focus on Otologic Surgeries"],"prefix":"10.7759","author":[{"given":"Khushboo","family":"Bairwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Kewalramani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Vaswani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh","family":"Somvanshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Bairwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01227-6","article-title":"Prophylactic antiemetic effects of dexamethasone versus 5-HT3 receptor antagonists in ear surgery: a systematic review and meta-analysis","volume":"43","author":"Liu HM","year":"2021","unstructured":"Liu HM, Chen JH, Chen C, Liou CM. Prophylactic antiemetic effects of dexamethasone versus 5-HT3 receptor antagonists in ear surgery: a systematic review and meta-analysis. Int J Clin Pharm. 2021, 43:476-85. 10.1007\/s11096-020-01227-6","journal-title":"Int J Clin Pharm"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0761-9","article-title":"Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis","volume":"14","author":"Tricco AC","year":"2016","unstructured":"Tricco AC, Blondal E, Veroniki AA, et al.. Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis. BMC Med. 2016, 14:216. 10.1186\/s12916-016-0761-9","journal-title":"BMC Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0663-3","article-title":"Comparative pharmacology and guide to the use of the serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting","volume":"76","author":"Kovac AL","year":"2016","unstructured":"Kovac AL. Comparative pharmacology and guide to the use of the serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting. Drugs. 2016, 76:1719-35. 10.1007\/s40265-016-0663-3","journal-title":"Drugs"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.aan.2023.05.002","article-title":"A postoperative nausea and vomiting update: current information on new drugs, old drugs, rescue\/treatment, combination therapies and nontraditional modalities","volume":"41","author":"Meyer TA","year":"2023","unstructured":"Meyer TA, Hutson LR Jr, Morris PM, McAllister RK. A postoperative nausea and vomiting update: current information on new drugs, old drugs, rescue\/treatment, combination therapies and nontraditional modalities. Adv Anesth. 2023, 41:17-38. 10.1016\/j.aan.2023.05.002","journal-title":"Adv Anesth"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/anrp\/4976637","article-title":"Study the effect of intraperitoneal dexamethasone, dexmedetomidine, and their combination on PONV after laparoscopic cholecystectomy: a randomized triple-blind trial","volume":"2025","author":"Bauiomy H","year":"2025","unstructured":"Bauiomy H, Kohaf NA, Saad M, et al.. Study the effect of intraperitoneal dexamethasone, dexmedetomidine, and their combination on PONV after laparoscopic cholecystectomy: a randomized triple-blind trial. Anesthesiol Res Pract. 2025, 2025:4976637. 10.1155\/anrp\/4976637","journal-title":"Anesthesiol Res Pract"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/psb.1591","article-title":"Causes and treatment of nausea and vomiting","volume":"28","author":"Bhakta A","year":"2017","unstructured":"Bhakta A, Goel R. Causes and treatment of nausea and vomiting. Prescriber. 2017, 28:17-23. 10.1002\/psb.1591","journal-title":"Prescriber"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022","article-title":"A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers","volume":"91","author":"Apfel CC","year":"1999","unstructured":"Apfel CC, L\u00e4\u00e4r\u00e4 E, Koivuranta M, et al.. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999, 91:693-700. 10.1097\/00000542-199909000-00022","journal-title":"Anesthesiology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199611000-00014","article-title":"Omission of nitrous oxide during anesthesia reduces the incidence of postoperative nausea and vomiting. A meta-analysis","volume":"85","author":"Divatia JV","year":"1996","unstructured":"Divatia JV, Vaidya JS, Badwe RA, Hawaldar RW. Omission of nitrous oxide during anesthesia reduces the incidence of postoperative nausea and vomiting. A meta-analysis. Anesthesiology. 1996, 85:1055-62. 10.1097\/00000542-199611000-00014","journal-title":"Anesthesiology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.SA.0000452811.65196.db","article-title":"Nitrous oxide-related postoperative nausea and vomiting depends on duration of exposure","volume":"58","author":"Peyton PJ","year":"2014","unstructured":"Peyton PJ, Wu CYX. Nitrous oxide-related postoperative nausea and vomiting depends on duration of exposure. Sur Anes. 2014, 58:246-247. 10.1097\/01.SA.0000452811.65196.db","journal-title":"Sur Anes"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000460","article-title":"Questioning a relationship between nitrous oxide duration of exposure and postoperative nausea and vomiting","volume":"121","author":"Pace NL","year":"2014","unstructured":"Pace NL. Questioning a relationship between nitrous oxide duration of exposure and postoperative nausea and vomiting. Anesthesiology. 2014, 121:1356-8. 10.1097\/ALN.0000000000000460","journal-title":"Anesthesiology"},{"key":"ref11","article-title":"Prophylactic antiemetic effects of Midazolam, Ondansetron, and their combination after middle ear surgery","volume":"5","author":"Honarmand A","year":"2016","unstructured":"Honarmand A, Safavi M, Chegeni M, et al.. Prophylactic antiemetic effects of Midazolam, Ondansetron, and their combination after middle ear surgery. J Res Pharm Pract. 2016, 5:16-21.","journal-title":"J Res Pharm Pract"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.28920\/dhm47.2.97-109","article-title":"Scuba diving and otology: a systematic review with recommendations on diagnosis, treatment and post-operative care","volume":"47","author":"Livingstone DM","year":"2017","unstructured":"Livingstone DM, Smith KA, Lange B. Scuba diving and otology: a systematic review with recommendations on diagnosis, treatment and post-operative care. Diving Hyperb Med. 2017, 47:97-109. 10.28920\/dhm47.2.97-109","journal-title":"Diving Hyperb Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319872165","article-title":"Overstay and readmission in ear, nose, and throat day surgery\u2014factors affecting postanesthesia course","volume":"100","author":"Tolvi M","year":"2021","unstructured":"Tolvi M, Lehtonen L, Tuominen-Salo H, et al.. Overstay and readmission in ear, nose, and throat day surgery\u2014factors affecting postanesthesia course. Ear Nose Throat J. 2021, 100:477-82. 10.1177\/0145561319872165","journal-title":"Ear Nose Throat J"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-020-01996-6","article-title":"Comparison of palonosetron with combination of palonosetron and dexamethasone in the prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery: a prospective randomized trial","volume":"74","author":"Sahni N","year":"2022","unstructured":"Sahni N, Panda N, Kumar A, et al.. Comparison of palonosetron with combination of palonosetron and dexamethasone in the prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery: a prospective randomized trial. Indian J Otolaryngol Head Neck Surg. 2022, 74:3582-8. 10.1007\/s12070-020-01996-6","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2020.05.009","article-title":"Perioperative pain management following otologic surgery","volume":"53","author":"Morrison DR","year":"2020","unstructured":"Morrison DR, Moore LS, Walsh EM. Perioperative pain management following otologic surgery\r\n. Otolaryngol Clin North Am. 2020, 53:803-10. 10.1016\/j.otc.2020.05.009","journal-title":"Otolaryngol Clin North Am"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/ONO.0000000000000075","article-title":"Assessment of anesthetic modalities in otologic surgery","volume":"5","author":"Bao PH","year":"2025","unstructured":"Bao PH, Friedland DR, Adams JA, et al.. Assessment of anesthetic modalities in otologic surgery. Otol Neurotol Open. 2025, 5:e075. 10.1097\/ONO.0000000000000075","journal-title":"Otol Neurotol Open"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/wjo2.58","article-title":"Enhanced recovery after surgery protocols for outpatient operations in otolaryngology: Review of literature","volume":"8","author":"Chorath K","year":"2022","unstructured":"Chorath K, Hobday S, Suresh NV, et al.. Enhanced recovery after surgery protocols for outpatient operations in otolaryngology: Review of literature. World J Otorhinolaryngol Head Neck Surg. 2022, 8:96-106. 10.1002\/wjo2.58","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320928222","article-title":"Application of enhanced recovery after surgery in perioperative period of tympanoplasty and mastoidectomy","volume":"100","author":"Tan JQ","year":"2021","unstructured":"Tan JQ, Chen YB, Wang WH, et al.. Application of enhanced recovery after surgery in perioperative period of tympanoplasty and mastoidectomy. Ear Nose Throat J. 2021, 100:1045S-9S. 10.1177\/0145561320928222","journal-title":"Ear Nose Throat J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2020.09.004","article-title":"Prevention of postoperative nausea and vomiting: new insights for patient care","volume":"70","author":"Schmidt AP","year":"2020","unstructured":"Schmidt AP. Prevention of postoperative nausea and vomiting: new insights for patient care. Braz J Anesthesiol. 2020, 70:452-4. 10.1016\/j.bjan.2020.09.004","journal-title":"Braz J Anesthesiol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.21832.1","article-title":"Management strategies for the treatment and prevention of postoperative\/postdischarge nausea and vomiting: an updated review","volume":"9","author":"Elvir-Lazo OL","year":"2020","unstructured":"Elvir-Lazo OL, White PF, Yumul R, Cruz Eng H. Management strategies for the treatment and prevention of postoperative\/postdischarge nausea and vomiting: an updated review. F1000Res. 2020, 9:10.12688\/f1000research.21832.1","journal-title":"F1000Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2025.02.003","article-title":"Pathophysiology and risk factors for postoperative nausea and vomiting in adults and children","volume":"25","author":"Kovac AL","year":"2025","unstructured":"Kovac AL. Pathophysiology and risk factors for postoperative nausea and vomiting in adults and children. BJA Educ. 2025, 25:234-9. 10.1016\/j.bjae.2025.02.003","journal-title":"BJA Educ"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-02632-1","article-title":"The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review","volume":"30","author":"Zhang Z","year":"2025","unstructured":"Zhang Z, Wang X. The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review. Eur J Med Res. 2025, 30:362. 10.1186\/s40001-025-02632-1","journal-title":"Eur J Med Res"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002845","article-title":"Incidence and risk factors of postoperative nausea and vomiting in Africa among patient under gone surgery: a systematic review and meta-analysis","volume":"87","author":"Bacho MT","year":"2025","unstructured":"Bacho MT, Wolda GD, Demssie WR, et al.. Incidence and risk factors of postoperative nausea and vomiting in Africa among patient under gone surgery: a systematic review and meta-analysis. Ann Med Surg (Lond). 2025, 87:285-98. 10.1097\/MS9.0000000000002845","journal-title":"Ann Med Surg (Lond)"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.10.034","article-title":"Dexamethasone combined with other antiemetics versus single antiemetics for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: An updated systematic review and meta-analysis","volume":"36","author":"Awad K","year":"2016","unstructured":"Awad K, Ahmed H, Abushouk AI, et al.. Dexamethasone combined with other antiemetics versus single antiemetics for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: An updated systematic review and meta-analysis. Int J Surg. 2016, 36:152-63. 10.1016\/j.ijsu.2016.10.034","journal-title":"Int J Surg"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/11101849.2021.1916860","article-title":"Granisetron vs. granisetron and dexamethasone on the reduction of postoperative nausea and vomiting (PONV) after caesarean section with intrathecal morphine: a randomised controlled trial","volume":"37","author":"Mohd DFN","year":"2021","unstructured":"Mohd DFN, Seevaunnamtum SP, Mohamad NNA, et al.. Granisetron vs. granisetron and dexamethasone on the reduction of postoperative nausea and vomiting (PONV) after caesarean section with intrathecal morphine: a randomised controlled trial. Egypt J Anaesth. 2021, 37:196-201. 10.1080\/11101849.2021.1916860","journal-title":"Egypt J Anaesth"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4103\/ijciis.ijciis_150_20","article-title":"A comparison of prophylactic antiemetic therapy with palonosetron and dexamethasone as single-agents or in combination in adult patients undergoing laparoscopic surgery: A randomized trial","volume":"13","author":"Sadhoo N","year":"2023","unstructured":"Sadhoo N, Prakash J, Kumar V, et al.. A comparison of prophylactic antiemetic therapy with palonosetron and dexamethasone as single-agents or in combination in adult patients undergoing laparoscopic surgery: A randomized trial. Int J Crit Illn Inj Sci. 2023, 13:4-10. 10.4103\/ijciis.ijciis_150_20","journal-title":"Int J Crit Illn Inj Sci"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.21276\/aan.2019.4.2.61","article-title":"Study comparing high dose palanosetron 0.075 mg with low dose palanosetron 0.05 mg plus 4mg dexamethasone as adjuvant for prevention of post-operative nausea and vomiting in laproscopic hysterectomies-a double blinded study","volume":"4","author":"Jain P","year":"2019","unstructured":"Jain P, Ahluwalia P, Ahluwalia A, Jain R. Study comparing high dose palanosetron 0.075 mg with low dose palanosetron 0.05 mg plus 4mg dexamethasone as adjuvant for prevention of post-operative nausea and vomiting in laproscopic hysterectomies-a double blinded study. Ann Advan Nurs. 2019, 4:61. 10.21276\/aan.2019.4.2.61","journal-title":"Ann Advan Nurs"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2015.51","article-title":"Postoperative nausea and vomiting: palanosetron with dexamethasone vs. ondansetron with dexamethasone in laparoscopic hysterectomies","volume":"30","author":"Sharma AN","year":"2015","unstructured":"Sharma AN, Shankaranarayana P. Postoperative nausea and vomiting: palanosetron with dexamethasone vs. ondansetron with dexamethasone in laparoscopic hysterectomies. Oman Med J. 2015, 30:252-6. 10.5001\/omj.2015.51","journal-title":"Oman Med J"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_317_17","article-title":"Comparison of efficacy of palonosetron-dexamethasone combination with palonosetron or dexamethasone alone for prophylaxis against post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy","volume":"61","author":"Chatterjee A","year":"2017","unstructured":"Chatterjee A, Sahu S, Paul M, et al.. Comparison of efficacy of palonosetron-dexamethasone combination with palonosetron or dexamethasone alone for prophylaxis against post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Indian J Anaesth. 2017, 61:978-84. 10.4103\/ija.IJA_317_17","journal-title":"Indian J Anaesth"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_21_19","article-title":"Comparison of palonosetron and dexamethasone with ondansetron and dexamethasone to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy","volume":"13","author":"Rajnikant K","year":"2019","unstructured":"Rajnikant K, Bhukal I, Kaloria N, et al.. Comparison of palonosetron and dexamethasone with ondansetron and dexamethasone to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Anesth Essays Res. 2019, 13:317-22. 10.4103\/aer.AER_21_19","journal-title":"Anesth Essays Res"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517703276","article-title":"Granisetron plus dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis","volume":"45","author":"Zhu M","year":"2017","unstructured":"Zhu M, Zhou C, Huang B, et al.. Granisetron plus dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis. J Int Med Res. 2017, 45:904-11. 10.1177\/0300060517703276","journal-title":"J Int Med Res"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106051","article-title":"A comprehensive review on the pharmacological prospects of Terpinen-4-ol: From nature to medicine and beyond","volume":"176","author":"Prerna","year":"2024","unstructured":"Prerna, Chadha J, Khullar L, et al.. A comprehensive review on the pharmacological prospects of Terpinen-4-ol: From nature to medicine and beyond. Fitoterapia. 2024, 176:106051. 10.1016\/j.fitote.2024.106051","journal-title":"Fitoterapia"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20180288","article-title":"A comparative study of ondansetron and granisetron in combination with dexamethasone in prophylaxis for postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomies","volume":"6","author":"Nanjundaswamy NH","year":"2018","unstructured":"Nanjundaswamy NH, Sridhara RB. A comparative study of ondansetron and granisetron in combination with dexamethasone in prophylaxis for postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomies. Int J Res Med Sci. 2018, 6:503-508. 10.18203\/2320-6012.ijrms20180288","journal-title":"Int J Res Med Sci"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.191121","article-title":"Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study","volume":"10","author":"Gugale AA","year":"2016","unstructured":"Gugale AA, Bhalerao PM. Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study. Anesth Essays Res. 2016, 10:402-7. 10.4103\/0259-1162.191121","journal-title":"Anesth Essays Res"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-021-04257-7","article-title":"Evaluation of clinical outcomes and efficacy of palonosetron and granisetron in combination with dexamethasone in Egyptian patients receiving highly emetogenic chemotherapy","volume":"88","author":"A Mahrous M","year":"2021","unstructured":"A Mahrous M, A El-Azab G, A Tawfik H. Evaluation of clinical outcomes and efficacy of palonosetron and granisetron in combination with dexamethasone in Egyptian patients receiving highly emetogenic chemotherapy. Cancer Chemother Pharmacol. 2021, 88:121-9. 10.1007\/s00280-021-04257-7","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.199851","article-title":"Intravenous palonosetron compared with a combination of ramosetron and dexamethasone in preventing post operative nausea and vomiting in patients undergoing gynaecological surgeries under spinal anaesthesia, a randomised study","volume":"61","author":"Narayanappa AB","year":"2017","unstructured":"Narayanappa AB, Gurulingaswamy S, Prabhakaraiah UN, et al.. Intravenous palonosetron compared with a combination of ramosetron and dexamethasone in preventing post operative nausea and vomiting in patients undergoing gynaecological surgeries under spinal anaesthesia, a randomised study. Indian J Anaesth. 2017, 61:144-9. 10.4103\/0019-5049.199851","journal-title":"Indian J Anaesth"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20201319","article-title":"Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery","volume":"8","author":"Sharma SK","year":"2020","unstructured":"Sharma SK, Singh S, Paul D, et al.. Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery. Int J Res Med Sci. 2020, 8:1331-1335. 10.18203\/2320-6012.ijrms20201319","journal-title":"Int J Res Med Sci"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2025\/78582.21094","article-title":"Comparative study of intravenous granisetron against ondansetron in preventing postoperative nausea vomiting in patients undergoing general anaesthesia: a double-blinded randomised controlled study","volume":"19","author":"Vishwasrao SS","year":"2025","unstructured":"Vishwasrao SS, Vishwasrao SM, Kumar AN. Comparative study of intravenous granisetron against ondansetron in preventing postoperative nausea vomiting in patients undergoing general anaesthesia: a double-blinded randomised controlled study. J Clin Diagn Res. 2025, 19:10.7860\/JCDR\/2025\/78582.21094","journal-title":"J Clin Diagn Res"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.18535\/jmscr\/v5i4.203","article-title":"Palonosetron and granisetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective comparative randomised active controlled trial","volume":"5","author":"Makwana J","year":"2017","unstructured":"Makwana J, Vadodariya D, Vadodariya B. Palonosetron and granisetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective comparative randomised active controlled trial. J Med Sci Clin Res. 2017, 5:203. 10.18535\/jmscr\/v5i4.203","journal-title":"J Med Sci Clin Res"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227490","article-title":"A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients","volume":"15","author":"Gouveia de Araujo Ferreira N","year":"2020","unstructured":"Gouveia de Araujo Ferreira N, Cavalcanti IL, Assad AR, et al.. A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients. PLoS One. 2020, 15:e0227490. 10.1371\/journal.pone.0227490","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-024-04059-4","article-title":"Citral and triclosan synergistically silence quorum sensing and potentiate antivirulence response in Pseudomonas aeruginosa","volume":"206","author":"Chadha J","year":"2024","unstructured":"Chadha J, Ahuja P, Mudgil U, et al.. Citral and triclosan synergistically silence quorum sensing and potentiate antivirulence response in Pseudomonas aeruginosa. Arch Microbiol. 2024, 206:324. 10.1007\/s00203-024-04059-4","journal-title":"Arch Microbiol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.aan.2018.07.004","article-title":"Updates in the management of postoperative nausea and vomiting","volume":"36","author":"Kovac AL","year":"2018","unstructured":"Kovac AL. Updates in the management of postoperative nausea and vomiting. Adv Anesth. 2018, 36:81-97. 10.1016\/j.aan.2018.07.004","journal-title":"Adv Anesth"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026438","article-title":"Comparison of efficacy between palonosetron-midazolam combination and palonosetron alone for prevention of postoperative nausea and vomiting in patients undergoing breast surgery and patient controlled analgesia: A prospective, randomized, double-blind study: A CONSORT-compliant study","volume":"100","author":"Hong JM","year":"2021","unstructured":"Hong JM, Han YH, Lee D, et al.. Comparison of efficacy between palonosetron-midazolam combination and palonosetron alone for prevention of postoperative nausea and vomiting in patients undergoing breast surgery and patient controlled analgesia: A prospective, randomized, double-blind study: A CONSORT-compliant study. Medicine (Baltimore). 2021, 100:e26438. 10.1097\/MD.0000000000026438","journal-title":"Medicine (Baltimore)"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_183_17","article-title":"Comparison of palonosetron, dexamethasone, and palonosetron plus dexamethasone as prophylactic antiemetic and antipruritic drug in patients receiving intrathecal morphine for lower segment cesarean section","volume":"12","author":"Swaro S","year":"2018","unstructured":"Swaro S, Karan D, Banerjee A. Comparison of palonosetron, dexamethasone, and palonosetron plus dexamethasone as prophylactic antiemetic and antipruritic drug in patients receiving intrathecal morphine for lower segment cesarean section. Anesth Essays Res. 2018, 12:322-7. 10.4103\/aer.AER_183_17","journal-title":"Anesth Essays Res"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.53730\/ijhs.v6nS6.10056","article-title":"Efficacy of ondansetron alone, dexamethasone alone and combination of ondansetron and dexamethasone for PONV for patients undergoing under general anaesthesia","volume":"6","author":"Chitta P","year":"2022","unstructured":"Chitta P, Mothe G, Alugolu M, Leela KS. Efficacy of ondansetron alone, dexamethasone alone and combination of ondansetron and dexamethasone for PONV for patients undergoing under general anaesthesia. Int J Health Sci. 2022, 6:2346-2360. 10.53730\/ijhs.v6nS6.10056","journal-title":"Int J Health Sci"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1688","article-title":"Aprepitant plus palonosetron for the prevention of postoperative nausea and vomiting after breast cancer surgery: a double blind, randomized trial","volume":"75","author":"Grigio TR","year":"2020","unstructured":"Grigio TR, Sousa AM, Magalh\u00e3es GG, et al.. Aprepitant plus palonosetron for the prevention of postoperative nausea and vomiting after breast cancer surgery: a double blind, randomized trial. Clinics (Sao Paulo). 2020, 75:e1688. 10.6061\/clinics\/2020\/e1688","journal-title":"Clinics (Sao Paulo)"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001617","article-title":"Combination of 5-HT3 antagonist and dexamethasone is superior to 5-HT3 antagonist alone for PONV prophylaxis after laparoscopic surgeries: a meta-analysis","volume":"123","author":"Som A","year":"2016","unstructured":"Som A, Bhattacharjee S, Maitra S, et al.. Combination of 5-HT3 antagonist and dexamethasone is superior to 5-HT3 antagonist alone for PONV prophylaxis after laparoscopic surgeries: a meta-analysis. Anesth Analg. 2016, 123:1418-26. 10.1213\/ANE.0000000000001617","journal-title":"Anesth Analg"},{"key":"ref48","article-title":"Antiemetic efficacy of palanosetron compared with the combination of ondansetron and dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic gynaecological surgery","volume":"28","author":"Dey S","year":"2021","unstructured":"Dey S, Chanu SM, Dev P, et al.. Antiemetic efficacy of palanosetron compared with the combination of ondansetron and dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic gynaecological surgery. Rom J Anaesth Intensive Care. 2021, 28:19-24.","journal-title":"Rom J Anaesth Intensive Care"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/464093-comparative-efficacy-of-palonosetron-dexamethasone-versus-granisetron-dexamethasone-for-prevention-of-postoperative-nausea-and-vomiting-a-review-with-focus-on-otologic-surgeries","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:01:34Z","timestamp":1771840894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/464093-comparative-efficacy-of-palonosetron-dexamethasone-versus-granisetron-dexamethasone-for-prevention-of-postoperative-nausea-and-vomiting-a-review-with-focus-on-otologic-surgeries"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":48,"URL":"https:\/\/doi.org\/10.7759\/cureus.104098","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,23]]}}}