{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:11:45Z","timestamp":1771942305004,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,24]]},"DOI":"10.7759\/cureus.104181","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T13:39:57Z","timestamp":1771940397000},"source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics of Continuous Local Antibiotic Perfusion in Fresh-Frozen Cadaver Models of Hip and Knee Arthroplasties"],"prefix":"10.7759","author":[{"given":"Tomomi","family":"Mizuhashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsufumi","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sukegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukie","family":"Metoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Himeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Takaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyuki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Ujihira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2017.05.003","article-title":"Infection burden in total hip and knee arthroplasties: an international registry-based perspective","volume":"3","author":"Springer BD","year":"2017","unstructured":"Springer BD, Cahue S, Etkin CD, Lewallen DG, McGrory BJ. Infection burden in total hip and knee arthroplasties: an international registry-based perspective. Arthroplast Today. 2017, 3:137-40. 10.1016\/j.artd.2017.05.003","journal-title":"Arthroplast Today"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon DR","year":"2013","unstructured":"Osmon DR, Berbari EF, Berendt AR, et al.. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013, 56:e1-25. 10.1093\/cid\/cis803","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2020.11.010","article-title":"A novel treatment strategy using continuous local antibiotic perfusion: a case series study of a refractory infection caused by hypervirulent Klebsiella pneumoniae","volume":"27","author":"Himeno D","year":"2022","unstructured":"Himeno D, Matsuura Y, Maruo A, Ohtori S. A novel treatment strategy using continuous local antibiotic perfusion: a case series study of a refractory infection caused by hypervirulent Klebsiella pneumoniae. J Orthop Sci. 2022, 27:272-80. 10.1016\/j.jos.2020.11.010","journal-title":"J Orthop Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.6.1771-1776.1999","article-title":"The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms","volume":"37","author":"Ceri H","year":"1999","unstructured":"Ceri H, Olson ME, Stremick C, Read RR, Morck D, Buret A. The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol. 1999, 37:1771-6. 10.1128\/JCM.37.6.1771-1776.1999","journal-title":"J Clin Microbiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.048678-0","article-title":"Inhibition of biofilm maturation by linezolid in meticillin-resistant Staphylococcus epidermidis clinical isolates: comparison with other drugs","volume":"62","author":"Reiter KC","year":"2013","unstructured":"Reiter KC, Villa B, Paim TG, de Oliveira CF, d'Azevedo PA. Inhibition of biofilm maturation by linezolid in meticillin-resistant Staphylococcus epidermidis clinical isolates: comparison with other drugs. J Med Microbiol. 2013, 62:394-9. 10.1099\/jmm.0.048678-0","journal-title":"J Med Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00647-24","article-title":"Effective biofilm eradication in MRSA isolates with aminoglycoside-modifying enzyme genes using high-concentration and prolonged gentamicin treatment","volume":"12","author":"Ando K","year":"2024","unstructured":"Ando K, Miyahara S, Hanada S, et al.. Effective biofilm eradication in MRSA isolates with aminoglycoside-modifying enzyme genes using high-concentration and prolonged gentamicin treatment. Microbiol Spectr. 2024, 12:e0064724. 10.1128\/spectrum.00647-24","journal-title":"Microbiol Spectr"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/23094990211051492","article-title":"Intra-medullary antibiotics perfusion (iMAP) for the control of fracture-related infection early after osteosynthesis","volume":"29","author":"Maruo A","year":"2021","unstructured":"Maruo A, Oda T, Miya H, et al.. Intra-medullary antibiotics perfusion (iMAP) for the control of fracture-related infection early after osteosynthesis. J Orthop Surg (Hong Kong). 2021, 29:23094990211051492. 10.1177\/23094990211051492","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ase.2138","article-title":"Current and potential use of fresh frozen cadaver in surgical training and anatomical education","volume":"15","author":"Song YK","year":"2022","unstructured":"Song YK, Jo DH. Current and potential use of fresh frozen cadaver in surgical training and anatomical education. Anat Sci Educ. 2022, 15:957-69. 10.1002\/ase.2138","journal-title":"Anat Sci Educ"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12504","article-title":"A comparative study of vascular injection fluids in fresh-frozen and embalmed human cadaver forearms","volume":"229","author":"Doomernik DE","year":"2016","unstructured":"Doomernik DE, Kruse RR, Reijnen MM, Kozicz TL, Kooloos JG. A comparative study of vascular injection fluids in fresh-frozen and embalmed human cadaver forearms. J Anat. 2016, 229:582-90. 10.1111\/joa.12504","journal-title":"J Anat"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12361","article-title":"Fresh frozen cadaver workshops for advanced vascular surgical training","volume":"84","author":"Jansen S","year":"2014","unstructured":"Jansen S, Cowie M, Linehan J, Hamdorf JM. Fresh frozen cadaver workshops for advanced vascular surgical training. ANZ J Surg. 2014, 84:877-80. 10.1111\/ans.12361","journal-title":"ANZ J Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-022-04677-x","article-title":"The simulation of terrible triad injuries in fresh-frozen human cadaveric specimens with intact soft tissue envelope","volume":"143","author":"Lanzerath F","year":"2023","unstructured":"Lanzerath F, Knifka J, Leschinger T, et al.. The simulation of terrible triad injuries in fresh-frozen human cadaveric specimens with intact soft tissue envelope. Arch Orthop Trauma Surg. 2023, 143:4229-37. 10.1007\/s00402-022-04677-x","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2563939","article-title":"Continuous local antibiotics perfusion therapy for acute deep infections after open fractures","volume":"2022","author":"Takahara S","year":"2022","unstructured":"Takahara S, Maruo A, Takayama H, Harada T. Continuous local antibiotics perfusion therapy for acute deep infections after open fractures. Case Rep Orthop. 2022, 2022:2563939. 10.1155\/2022\/2563939","journal-title":"Case Rep Orthop"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/10225536221111902","article-title":"Continuous local antibiotic perfusion: a treatment strategy that allows implant retention in fracture-related infections","volume":"30","author":"Maruo A","year":"2022","unstructured":"Maruo A, Oda T, Mineo R, et al.. Continuous local antibiotic perfusion: a treatment strategy that allows implant retention in fracture-related infections. J Orthop Surg (Hong Kong). 2022, 30:10225536221111902. 10.1177\/10225536221111902","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.13107\/jocr.2022.v12.i02.2648","article-title":"Continuous local antibiotic perfusion (CLAP) for post-operative infection of open tibial fractures: a case report","volume":"12","author":"Mineo R","year":"2022","unstructured":"Mineo R, Oe K, Niikura T, Muratsu H, Kuroda R, Maruo A. Continuous local antibiotic perfusion (CLAP) for post-operative infection of open tibial fractures: a case report. J Orthop Case Rep. 2022, 12:18-22. 10.13107\/jocr.2022.v12.i02.2648","journal-title":"J Orthop Case Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2023.12.001","article-title":"Treatment experience with continuous local antibiotic perfusion for periprosthetic joint infection","volume":"29","author":"Miyake Y","year":"2024","unstructured":"Miyake Y, Takagi T. Treatment experience with continuous local antibiotic perfusion for periprosthetic joint infection. J Orthop Sci. 2024, 29:1469-76. 10.1016\/j.jos.2023.12.001","journal-title":"J Orthop Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-07165-y","article-title":"DAIR in treating chronic PJI after total knee arthroplasty using continuous local antibiotic perfusion therapy: a case series study","volume":"25","author":"Zenke Y","year":"2024","unstructured":"Zenke Y, Motojima Y, Ando K, et al.. DAIR in treating chronic PJI after total knee arthroplasty using continuous local antibiotic perfusion therapy: a case series study. BMC Musculoskelet Disord. 2024, 25:36. 10.1186\/s12891-024-07165-y","journal-title":"BMC Musculoskelet Disord"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-11808-y","article-title":"Clinical outcomes of continuous local antibiotic perfusion in combination with debridement antibiotics and implant retention for periprosthetic hip joint infection","volume":"15","author":"Hieda Y","year":"2025","unstructured":"Hieda Y, Choe H, Maruo A, et al.. Clinical outcomes of continuous local antibiotic perfusion in combination with debridement antibiotics and implant retention for periprosthetic hip joint infection. Sci Rep. 2025, 15:26017. 10.1038\/s41598-025-11808-y","journal-title":"Sci Rep"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2023.101245","article-title":"Novel local antifungal treatment for fungal periprosthetic joint infection with continuous local antibiotic perfusion: a surgical technique","volume":"24","author":"Choe H","year":"2023","unstructured":"Choe H, Maruo A, Hieda Y, et al.. Novel local antifungal treatment for fungal periprosthetic joint infection with continuous local antibiotic perfusion: a surgical technique. Arthroplast Today. 2023, 24:101245. 10.1016\/j.artd.2023.101245","journal-title":"Arthroplast Today"},{"key":"ref19","article-title":"Pharmacokinetics of antimicrobials administered into cadaveric tibial bone marrow from intra-medullary antibiotics perfusion (iMAP) (Article in Japanese)","volume":"42","author":"Maruo A","year":"2020","unstructured":"Maruo A, Fukui T, Oe K, et al.. Pharmacokinetics of antimicrobials administered into cadaveric tibial bone marrow from intra-medullary antibiotics perfusion (iMAP) (Article in Japanese). Kossetsu. 2020, 42:1-5.","journal-title":"Kossetsu"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1051\/sicotj\/2024048","article-title":"High-concentration continuous local antibacterial perfusion therapy: safety and potential efficacy for acute and chronic periprosthetic knee joint infection","volume":"10","author":"Suzuki Y","year":"2024","unstructured":"Suzuki Y, Iwasaki K, Joutoku Z, et al.. High-concentration continuous local antibacterial perfusion therapy: safety and potential efficacy for acute and chronic periprosthetic knee joint infection. SICOT J. 2024, 10:51. 10.1051\/sicotj\/2024048","journal-title":"SICOT J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/455636-pharmacokinetics-of-continuous-local-antibiotic-perfusion-in-fresh-frozen-cadaver-models-of-hip-and-knee-arthroplasties","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T13:39:57Z","timestamp":1771940397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/455636-pharmacokinetics-of-continuous-local-antibiotic-perfusion-in-fresh-frozen-cadaver-models-of-hip-and-knee-arthroplasties"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.104181","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,24]]}}}